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SAN DIEGO (KGTV) — Mardi Gras is right around the corner, which means San Diegans are getting ready to "laissez les bons temps rouler" (let the good times roll.)Several events this weekend will kick off the local festivities in San Diego. All of it culminating on March 5, known as "Fat Tuesday,"traditionally the last day of the Carnival season.Looking for Kings Cake as well? Try out this delicious recipe from San Diego Family Magazine!Here are some great events you won't want to miss out on:San Diego Mardi Gras Fat Tuesday Celebration When: March 1 - 2, March 5 Where: Gaslamp District Cost: Starts at Mardi Gras gets started early in San Diego's Gaslamp District with 20 parties over the weekend and then for one more night on Fat Tuesday. Tickets get guests access to more than 20 nightclubs, bars, and restaurants, an opening night and finale party, and food and drink specials around downtown.Gaslamp District Mardi Gras Big Easy Bites & Booze TourWhen: March 2Where: Gaslamp DistrictCost: Starting at Enjoy a taste of San Diego and Mardi Gras with 20 Mardi-Gras inspired plates, Carnival cocktails, an exclusive after party at a secret location, and more during the Gaslamp Mardi Grass Big Easy Bites and Booze Tour through downtown.2nd annual Blvd. Mardi Gras CrawlWhen: March 3Where: El Cajon Boulevard, North ParkCost: Tickets are free for - specialsA traveling party will take over North Park's El Cajon Boulevard, bringing guests across local breweries, bars, and restaurants for drink and food specials, led by the Euphoria Brass Band along the way! The final stop will be a party at the Lafayette Hotel for music, dancing, and the best-decorated “Mardi-Bra” contest.Mardi Gras 10K & 5KWhen: March 3Where: Rancho Bernardo Community ParkCost: - Celebrate Mardi Gras and enjoy a Carnival in the park in Rancho Bernardo at the inaugural Mardi Gras 10K & 5K. Hit the scenic trails around RB in colorful Mardi Gras gear and enjoy a finish line festival!Mardi Gras Party at House of BluesWhen: March 5Where: House of Blues San DiegoCost: No cover, open to publicHouse of Blues celebrate Mardi Gras with a party at its restaurant and Voodoo Room, featuring a special food and drink menu, circus and interactie entertainment, and live music by Madame Leroux & Krewe. 17th Annual Hillcrest Mardi GrasWhen: March 5Where: Hillcrest Pride FlagCost: - Hillcrest will host a neighborhood-wide party crawl through the area's best bars, clubs, and music venues. Themed party stops will greet guests with drink deals, collectible beads, giveaways, and live entertainment! 2613

SAN DIEGO (KGTV) — Making your own pasta doesn't have to be reserved for restaurants, you can try it out in your own kitchen.Cucina Sorella's gnocci (isn't it fun to say?) is a delicious take on the pasta, working in rapini leaves and ground beef for a dish that will leave you ready for more.Chef Joe Magnanelli walked us through his recipe, adding that his version isn't the only way you can serve up the pasta — should you try it yourself at home.The Dish:GnocciWhat You'll Need: 520

SAN DIEGO (KGTV) -- Kevin Luo of Pacific Trails Middle School is getting ready for his trip to Washington D.C. to compete in the Scripps National Spelling Bee.Luo, who is a student at Pacific Trails Middle School, was crowned the winner of the countywide spelling bee in March. Last year's winner, Yash Hande, was also a student at Pacific Trails. Luo said in an interview with 10News that the Hande is helping him prepare for the national Bee.RELATED: Pacific Trails Middle School student crowned winner of countywide spelling bee  Luo also expressed that he is a little nervous to be on the national stage. “It’s probably going to be really intense for the first few days but after that, it will be relaxed.”The Scripps National Spelling Bee will take place May 29-31 in Washington, D.C. 832

SAN DIEGO (KGTV) - Locally and nationally, the calls are growing louder for some immigrant detainees to be released. In 2018, Kazakhstan native Satbay Kydyrali, 31, made his way to a local border crossing "He crossed border, turned himself in and asked for asylum," said Almas Irgebayev, Kydyrali's brother.Irgebayev says the asylum claim was denied and is now under appeal, a decision that could be years away. Meanwhile his brother continues to being held at Otay Mesa Detention Center. "Last three days, I was just crying when I think about him," said Irgebayev.Irgebayev says his brother is coughing, and in a cell with 7 other men. They are less than two feet apart, and most of the other men are also coughing. His brother told him none of the staff is wearing masks, and the detainees clean their own cell twice a day. The two brothers talk on the phone every day."He says that he wants to get out. I was crying on the phone. I heard him crying as well," said Irgebayev.Irgebayev is fearful because his brother is at-risk. He contracted tuberculosis as a child and has developed chronic breathing issues."I'm in a panic. I am feeling very bad, because I'm helpless," said Irgebayev. Similar sentiments were on display at a socially distant, vehicle protest near the federal courthouse downtown. Immigrant advocates were asking for at-risk detainees to be released. On the same day, members of the Congressional Hispanic Caucus called on Homeland Security officials to release low-priority detainees.In a statement, a DHS spokesperson says they're following CDC guidelines for disease monitoring and management protocols.' Irgabayev believes that statement doesn't reflect reality."I'm just afraid he is going to die in there," said Irgebayev.Irgabayev says his brother is in day three of a hunger strike protesting the conditions. The number of detainees on the hunger strike has shrunk from 90 to eight since the first day.An employee at the Otay Mesa Detention Center has tested positive, the first employee so far, according to prison company CivicCore. They employee reportedly didn't have contact with detainees. ICE says no detainees have tested positive for COVID-19. 2189

SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

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