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New research suggests that antibodies the immune system makes to fight the new coronavirus may only last a few months in people with mild illness, but that doesn’t mean protection also is gone or that it won’t be possible to develop an effective vaccine.“Infection with this coronavirus does not necessarily generate lifetime immunity,” but antibodies are only part of the story, said Dr. Buddy Creech, an infectious disease specialist at Vanderbilt University. He had no role in the work, published Tuesday in the New England Journal of Medicine.The immune system remembers how to make fresh antibodies if needed and other parts of it also can mount an attack, he said.Antibodies are proteins that white blood cells called B cells make to bind to the virus and help eliminate it. The earliest ones are fairly crude but as infection goes on, the immune system becomes trained to focus its attack and to make more precise antibodies.Dr. Otto Yang and others at the University of California, Los Angeles, measured these more precise antibodies in 30 patients diagnosed with COVID-19 and four housemates presumed to have the disease. Their average age was 43 and most had mild symptoms.Researchers found that the antibodies had a half-life of 73 days, which means that half of them would be gone after that much time. It dovetails with a previous report from China also suggesting antibodies quickly fade.The results “call for caution regarding antibody-based ‘immunity passports,’ herd immunity, and perhaps vaccine durability,” the California authors write.That’s true, Creech said, but other parts of the immune system also help confer protection. Besides churning out antibodies, B cells develop a memory so they know how to do that again if needed.“They would get called into action very quickly when there’s a new exposure to the virus. It’s as if they lie dormant, just waiting,” he said.Other white blood cells called T cells also are better able to attack the virus the next time they see it, Creech said.Although circulating antibodies may not last long, what we need to know is if and how people remake antibodies if exposed to the coronavirus again and if they protect against another infection, Alison Criss, an immunologist at the University of Virginia, wrote in an email. “We also need to know if there is a protective T cell response” that reappears.Vaccines, which provoke the immune system to make antibodies, might give longer-lasting protection than natural infection because they use purified versions of what stimulates that response, she noted.Creech agreed.“This shouldn’t dissuade us from pursuing a vaccine,” he said. “Antibodies are only a part of the story.”___Marilynn Marchione can be followed on Twitter at http://twitter.com/MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2967

NEW YORK (AP) — A tentative deal has been reached to settle multiple lawsuits brought against the television and film company co-founded by Harvey Weinstein, who has been accused of sexual misconduct by scores of women.Attorneys involved in the negotiations told a federal bankruptcy court judge during a hearing in Wilmington, Delaware, Thursday that a breakthrough in a still-unfinished mediation had put a settlement within reach.The amount of the deal wasn't revealed in court, but a person familiar with the negotiations told The Associated Press it was worth million. The person wasn't authorized to reveal details of the discussions and spoke on condition of anonymity."We now have an economic agreement in principal that is supported by the plaintiffs, the (New York attorney general's) office, the defendants and all of the insurers that, if approved, would provide significant compensation to victims, creditors and the estate and allow the parties to avoid years of costly, time consuming and uncertain litigation on all sides," Adam Harris, a lawyer for studio co-founder Bob Weinstein, told the judge.He cautioned that there was still "a lot of work here to do.""But," he added, "I personally am very optimistic."The size of the settlement was first reported by The Wall Street Journal.More than 15 lawsuits have been filed accusing Harvey Weinstein or the company of misconduct. The settlement would cover many of them, including a class action by alleged victims that accuses the film company of operating like an organized crime group to conceal widespread sexual harassment and assaults.It would also resolve a civil suit by the New York attorney general alleging that Harvey Weinstein's media company, in enabling his mistreatment of women, violated labor laws.The New York attorney general's office declined to comment on the amount of the settlement.Any settlement would need to be approved by the courts.Harvey Weinstein also faces criminal charges in New York of rape and performing a forcible sex act. His trial is scheduled to begin in September. The settlement wouldn't resolve his criminal case.Weinstein denies all allegations of nonconsensual sex.An attorney who represents unsecured creditors in the bankruptcy of the Weinstein film studio, Robert Feinstein, told U.S. Bankruptcy Court Judge Mary Walrath that mediation talks that had broken down a few months ago had recently been restarted.A global settlement of the class action lawsuit and all other legal action against the Weinstein Co. seemed to become possible only in the past few days, he said, though he cautioned that many details remained to be resolved."I think we are poised to get there. I can't assure the court that we will," he said.Harris said the settlement was complex due to the number of claims, and insurance companies, involved."We're dealing with potential claims here that go back . more than 25 years," he said, adding that the nature of the allegations had also made for "a highly charged environment, with very strong feelings on all sides."___Associated Press writer Randall Chase in Dover, Delaware, contributed to this report. 3151

New Yorkers are used to a lot of traffic. All day, every day streets are filled with cars, but for one day, busy streets will be car-free.In celebration of Earth Day, 30 blocks of New York City will only be open to pedestrian and bicycle traffic.From 9 a.m. to 3 p.m., Broadway will be closed to car traffic between Times Square and Union Square.Within those streets, several programs and activities will be made available to visitors, including fitness classes, performances and other activities.Citi Bike is also offering free day passes through its app.The goal is to encourage people to choose more environmentally-friendly methods of transportation.A portion of Washington Heights will also be closed between West 181st and West 190th streets on St. Nicholas Avenue.  785

Night Three of the Republican National Convention featured a number of mentions of the women’s suffrage movement and its historic leader Susan B. Anthony.The GOP played a video montage featuring Anthony. Moments later, second lady Karen Pence mentioned Anthony, saying that women fought hard for the right to vote, and they should vote for Donald Trump.“100 years ago today, the 19th amendment was adopted into the United States Constitution, guaranteeing women the right to vote. Because of heroes like Susan B. Anthony and Lucy Stone women today, like our daughters, Audrey and Charlotte, and future generations will have their voices heard and their votes count,” Pence said.Last week, President Donald Trump issued a post humorous pardon to Anthony.The pardon was rejected by the Susan B. Anthony Museum.The museum’s CEO, Deborah L. Hughes, said in a statement that the best way to honor Anthony is to restore provisions of the Voting Rights Act.“If one wants to honor Susan B. Anthony today, a clear stance against any form of voter suppression would be welcome. Enforcement and expansion of the Voting Rights Act of 1965 would be celebrated, we must assure that states respect the 14th, 15th, and 19th Amendments to the United States Constitution,” Hughes said. “Support for the Equal Rights Amendment would be well received. Advocacy for human rights for all would be splendid. Anthony was also a strong proponent of sex education, fair labor practices, excellent public education, equal pay for equal work, and elimination of all forms of discrimination.” 1571

NORTON, Kan. – A Kansas nursing home has been hit hard by COVID-19.All 62 of the residents at the Andbe Home in Norton have tested positive for the novel coronavirus and 10 of the patients have died as a result of the disease, according to the Norton County Health Department.In a press release, the health department said Monday that one of the surviving residents has been hospitalized and the remaining 51 are being cared for at the privately-owned nursing home facility.Additionally, the department says some staff members have tested positive for the virus, though a specific number was not provided.