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WASHINGTON, April 6 (Xinhua) -- U.S. researchers have discovered two genes in which variation affects intake of caffeine, the most widely consumed stimulant in the world, according to a report described Wednesday in the open-access journal PLoS Genetics.A team of investigators from the National Cancer Institute, Harvard School of Public Health, Brigham and Women's Hospital, and the University of North Carolina at Chapel Hill examined genetic variation across the entire genome of more than 47,000 individuals from the U.S.They found the genes -- CYP1A2, which has previously been implicated in the metabolism of caffeine, and AHR, involved in the regulation of CYP1A2, played roles in regulating intake of caffeine. Individuals with the highest-consumption genotype for either gene consumed 40 mg more caffeine than those with the lowest-consumption genotype, equivalent to the amount of one-third cup of caffeinated coffee, or one can of cola.Caffeine is implicated in numerous physiological and medical conditions; it affects sleep patterns, energy levels, mood, and mental and physical performance. The identification of genes that have an impact on daily consumption offers opportunities to better understand these conditions. Further exploration of the identified genetic variants may provide insight into the speed of caffeine metabolism, how long caffeine circulates in the blood, or how strong the physiological effects of consuming a given amount of caffeine are.

JERUSALEM, April 12 (Xinhua) -- Israeli-Canadian archaeologist Simcha Jacobovici may have stumbled upon a major archaeological find if his claim of unearthing the nails used to hold Jesus on the cross during his crucifixion are to be believed.Jacobovici maintains that small metal remains dug out of the soil in a cave in a Jerusalem neighborhood are in fact the nails that held Jesus on the cross, the Ha'aretz daily reported Tuesday.The artifacts were found in a cave in the Armon Hanatziv ridge, about 6 km south of the Old City, during the course of a construction work in 1990. The hilly area now contains apartment buildings.During the excavation of the cave, a stone vessel with the name Caiaphas, the name of the High Priest considered responsible for turning Jesus over to the Romans, and two rusty nails, which Jacobovici believes to be the relics, was unearthed.However, officials from the Israeli Antiquities Authority told Xinhua although they regard Jacobovici as a great archaeologist and documentary filmmaker, they do not believe the cave really belongs to the High Priest of the Second Temple period (between 536 BC and 70 AD)."The reason is that during that period of time there were a lot of people with the name Caiaphas," a statement from the Antiquities Authority said, "And for example, it is inconceivable that every gravestone bearing the name Moshe Dayan, which is very common in these parts, should be ascribed to the same personality who played so prominent a role in our recent history."Dayan was an Israeli army general who led his troops to victory in the 1967 war.The authority considers Jacobovici's contention as "fantasy" that should not be considered conclusive, since there is no agreed- upon evidence backing it up.Jacobovici is standing his ground, however, and contends that during the Second Temple Period the name Caiaphas was uncommon, and therefore the tomb must belong to the infamous priest.Jacobovici, a well-known documentary filmmaker, has produced films about the Israeli-Palestinian conflict and human trafficking that earned him two Emmy Awards.He also worked alongside film director James Cameron on the movie Jesus' Lost Tomb.He expects to soon release a movie about the latest finds, entitled Nails on the Cross.

WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.

MEXICO CITY, May 18 (Xinhua) -- The Mexican government signed an agreement with the non-governmental group TRAFFIC on Tuesday to exchange information about illegal seizures of flora and fauna species in Mexico.The agreement with the wildlife trade monitoring network also called for the Mexican government to provide information on the routes used to transport such organic materials.The agreement was signed on the sideline of the 16th meeting of the Trilateral Committee for Wildlife and Ecosystem Conservation Management in the city of Oaxaca, south Mexico. Representatives of Canada, the United States and Mexico also attended the meeting.Among the list of 20,000 animals, vegetation and insects that TRAFFIC considers to be threatened by illegal trafficking worldwide, 2,500 of the organisms have their origins in Mexico. This amounts to 12 percent of the species most subject to buying, selling and transporting in the black market and threatens the survival of various ecosystems.The Mexican species that are listed among the most threatened by illegal trafficking are the cactus, orchids, reptiles, maguey plants, ferns, amphibians and fish.

SAN FRANCISCO, April 27 (Xinhua) -- Apple Inc. on Wednesday denied the alleged location-tracking practice of its mobile operating system, saying it will release software updates to make iPhone store less location information to quell public concerns over privacy.CLARIFICATION"Apple is not tracking the location of your iPhone. Apple has never done so and has no plans to ever do so," the company said in a statement."Users are confused, partly because the creators of this new technology (including Apple) have not provided enough education about these issues to date."According to the statement, the location data researchers saw on iPhone is a database of Wi-Fi hotspots and cell towers around users' current location that Apple is maintaining to help iPhone rapidly and accurately calculate its location when requested. It noted Apple cannot locate iPhone users based on Wi-Fi hotspot and cell tower data as the information is in an anonymous and encrypted form.Apple admitted that part of the location data (Wi-Fi hotspots and cell towers) is backed up on iTunes, which means it could be possible that people with access to iPhone users'computer may get their location information. It said a software update has been planned to cease the backing-up.It is also planning to provide an update to limit the data storage on iPhone, in response to questions that the device has been storing location data since the release of iOS 4 operating system last June.Apple said it is a bug that iPhone keeps storing location data even if its location services are disabled, noting it will fix this through a software update in the coming weeks.The company also reiterated its focus on personal information security and privacy."Pretty much what I expected at this stage. The response is measured and the update should fix the problem," Alasdair Allan, one of the two British researchers who first announced the discovery of stored location data on iPhone, said on his Twitter account.ALLEGATIONThe statement on Wednesday is Apple's first official response to the location-tracking allegations.Worries on the iPhone tracking issue first surfaced last Wednesday when two British researchers announced at a technology conference in California that iPhone has been collecting users' location information and storing the data since June 21, 2010.Last Friday, The Wall Street Journal reported its security analysts had found that Apple's iPhone and smartphones running Google's Android operating system regularly transmit users' locations back to the two companies respectively, which is part of their race to build databases capable of pinpointing people's locations via smartphones.The newspaper then reported on Sunday that its analysts had also found iPhone is collecting and storing user's location data even when location services are turned off.PRESSUREThe Cupertino, California-based company has been facing mounting pressure from lawmakers, customers as well as media reports following the revelations.The U.S. House Energy and Commerce Committee on Monday sent letters to six developers of mobile device operating systems, including Apple and Google, demanding Apple's explanation on implications of alleged tracking for individual privacy and federal communications policy.Also on Monday, Minnesota Senator Al Franken, chairman of the U. S. Senate Judiciary Subcommittee on Privacy, Technology and the Law, announced he had scheduled a mobile privacy hearing on May 10 and asked representatives from Apple and Google to speak at the hearing.Meanwhile, Lisa Madigan, Attorney General of U.S. state of Illinois, on Monday called for a meeting with Apple and Google executives on the location-tracking reports, citing her ongoing effort to protect consumers' personal information online.Last Friday, two iPhone users filed a class action suit against Apple in Tempa, Florida, accusing the company of invasion of privacy and computer fraud and seeking a judge's order to bar the alleged data collection.Last Thursday, U.S. congressman Edward Markey asked Apple CEO Steve Jobs to make a response within 15 business days or no later than May 12, saying "Apple needs to safeguard personal location information of its users to ensure that an iPhone doesn't become an iTrack."On Saturday, Markey called for a congressional investigation into the privacy practices of Apple and Google. In a statement, he made clear that he thinks the data collection is potentially dangerous, saying predators could have hacked into an iPhone or Android phone to find out children's location information.Apple is also reportedly being investigated in South Korea, France, Germany and Italy over the alleged tracking practice.