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SAN DIEGO (KGTV) - Like Pfizer, Moderna, AstraZeneca, and many others, INOVIO Pharmaceuticals has also raced to develop a COVID-19 vaccine this year.“We’ve been working really hard to move our vaccine through the stages of clinical testing. Some things have taken a little bit longer than we hoped. I think that’s kind of always the case when you’re trying to go at great light speed,” said Dr. Kate Broderick, INOVIO Pharmaceuticals Senior VP of Research & Development based in San Diego.Broderick said with funding from the U.S. Department of Defense, the biotech company started its Phase 2 clinical trial evaluating its DNA vaccine candidate, INO-4800.The first U.S. participants received a dose of the experimental vaccine earlier this month. Approximately 400 adults in the U.S. are expected to be enrolled in the trial by the end of the month.“We hope that in the early part of 2021, we’ll be going into a really large Phase 3 trial where we’re asking the question does our vaccine protect against the disease itself,” she said.Broderick said the company hopes to enroll about 6,000 participants initially in its Phase 3 trial once they get the green light to begin.A press release from the company last week stated that “The Phase 3 segment of the INNOVATE remains on partial clinical hold until INOVIO satisfactorily resolves the FDA’s remaining questions related to the CELLECTRA 2000 device that will be used to deliver INO-4800 into the cells of the skin.”Earlier data released from Pfizer and Moderna’s studies showing high vaccine efficacy was positive news for INOVIO.“We feel that we’re in a really good place. There’s eight billion people on the planet, and we’re certainly going to need quite a few different types of vaccines to ensure everybody is protected,” she said. “The Moderna and Pfizer vaccines are RNA vaccines; ours is DNA vaccine”Broderick said one significant benefit of INOVIO’S DNA vaccine candidate is it doesn’t have to be stored in low-temperature freezers, making it easier to ship out worldwide if approved.“In fact, we can keep it at room temperature, sitting on a desk somewhere for a year with no impact,” she said.INOVIO is projecting to have 100 million doses of its vaccine ready in 2021.“With these vaccines being approved, there is definitely an end in sight, but don’t let your guard down too fast,” she said. “Unfortunately, until everyone in the country gets vaccinated, we will still have to adhere to those kinds of annoying things, wearing masks, socially distancing. I know it’s frustrating, especially before the holidays, but just keep yourself safe and the people you love safe.” 2648

SAN DIEGO (KGTV) -- It’s been more than seven decades since the creation of the beloved children’s character, Thomas the Tank Engine. The pandemic nearly derailed a local museum’s yearly family event.“This year is the 75th year of the creation of the book series, called ‘The Railway series,’ where Thomas was born,” said Katy Titus with the San Diego Model Railroad Museum.The Balboa Park museum hosts a Thomas Day Celebration every year. Thousands of kids, families, and train lovers stop at “Big Station” for the big event. Unfortunately, this year will be different.“Instead of Thomas taking over the physical museum, Thomas is going to take over our web presence,” says Titus.Thomas Takeover Week will run until Sunday. It’s a free virtual event.Visitors can explore the virtual exhibit. There are activities online for kids like arts and crafts. Students can also enjoy storytime, listening to “The Railway Series.”The San Diego Model Railroad Museum had to close its doors twice this year due to the pandemic. The museum is collecting donations that will be used to maintain the railroad collections and create more virtual programs. 1148

SAN DIEGO (KGTV) -- King tides are expected to continue in San Diego on Sunday following a day of flooding in parts of the county Saturday. High tide is set to happen at 9 a.m. with low tide set to take place around 4:10 p.m., according to tide charts. King tides occur when there is an alignment of the gravitational pull of the sun and the moon. RELATED: Sandbags available in San Diego CountySome parts of Imperial Beach already experienced tidal flooding Friday morning as several homeowners reported water entered their homes.The City of San Diego built a three-foot temporary berm along parts of the bay in Mission Beach to help mitigate the risk of coastal flooding. Residents can also check the likelihood of flooding in their area, via FEMA's flood map, here.The next round of king tides are expected to roll in January 20 an 21. 847

SAN DIEGO (KGTV) -- It's almost time for kids to head back to school, and that may have some parents considering their children's options. In California, parents have many options, including educating children at existing private schools, through a charter or independent study program, or by opening a private home-based school.But make no mistake; it’s a big undertaking. The State of California requires those choosing to homeschool their children to file a private school affidavit.RELATED: Back to school shopping comparison: Wide price range between Target, Staples, othersParents must provide all curricular, instructional and other materials. State rules also require parents to keep track of their children’s attendance.Another factor to consider is college. The state urges parents schooling at home to learn about student admission or eligibility at specific colleges and technical schools.RELATED: Tax-free weekend 2018: Participating states, dates and what you can buyFor parents considering homeschooling, it’s also important to know that the alternative diploma equivalencies for students who don’t attend public school are the GED or the California High School Proficiency Exam. 1217

SAN DIEGO (KGTV) — Local research organizations and San Diego County are teaming with the CDC to expand the genome sequencing of COVID-19. That data gives county leaders important information to drive decision-making to help slow and control the spread of the virus.“The virus is constantly evolving and trying to figure out the best way to spread through our population. And is it does that, it changes a little bit,” said Dr. Louise Laurent a professor at UC San Diego, which is part of the team, along with Scripps Research.Laurent says that studying changes in the virus can help identify which cases are connected to each other and which are not. The county can use that information to understand what measures are working, where there are significant outbreaks, and whether new measures are needed to stop those outbreaks.The county’s top epidemiologist, Dr. Eric McDonald, tells ABC 10News that the data shows that through testing and contract tracing, efforts to control outbreaks have generally been effective. “It looks like many of the instances of individuals who are infected don’t result in too many other infections. We don’t have lots of big clusters of the same exact strain,” McDonald said.The data also shows that while the restrictions and actions taken by the county have been effective in controlling outbreaks, COVID-19 continues to spread in San Diego through travel. “What we found is that San Diego has been hit many different times and viruses from other places have come to San Diego,” Laurent said. “We don’t want to be an isolated place. We want to interact, right? We’re just that kind of place. It makes us vibrant. It makes us an interesting place to be. But that also makes us vulnerable.”The research team recently received a .5 million contract from the CDC to expand its work. 1823

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