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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) — Tens of thousands of businesses in San Diego lost momentum in the early days of the pandemic. A leadership and facilitation company, literally named "momentum," was training corporations around the world when the pandemic hit. And it was clear to financially survive they had to pivot.Jason and Deirdre Maloney created the MagicWrap because they felt the world could use some warmth right now.“There's certainly people who are feeling isolated, feeling alone. Everybody likes a hug," Deirdre Maloney says.And a hug is just what a friend needed. But, when they couldn't find the gift they were looking for, they created it and brought MagicWrap to the market.“There's a concept about a blanket that's about covering yourself, and that's not what we wanted. We wanted that warmth like someone had their arms around you," Jason Maloney said. It even comes with a personalized note, and a pocket to keep it in. The pocket also makes a cell phone easy to walk around with. But before MagicWrap and product manufacturing, the Maloney's were a success in the field of corporate training and facilitation. Their company, Momentum, was booked solid into the fall.“For a company that goes around talking to businesses and they no longer exist. We have no business," said Jason.And their record-breaking year for Momentum, vanished.“It was a shock. Pretty much in a week our entire calendar year was put on hold, or canceled,” Jason added.But instead of folding, they found a new purpose, and the chance to spread a little magic in a trying time.“So when we hear back that people feel loved and supported or it's great to have this gift to give, that's really what it's about for us,” says Deirdre. 1714

SAN DIEGO (KGTV) -- The man accused of shooting two people outside a Metallica concert in the Gaslamp, including an off-duty sheriff’s deputy was back in court Tuesday.In July Ray Pitoau had his first trial. He was found guilty of three firearm charges, including felon in possession of a gun.The jury deadlocked when charging him with three counts of assault with a deadly weapon. The District Attorney’s Office refiled for a retrial.RELATED: Gaslamp deputy shooting suspect escapes Spring Valley SWAT standoffA few months later that retrial is in session and Pitoau now faces potential life in prison for allegedly shooting sheriff’s deputy Jason Philpot three times, aiming the gun at his brother, Joshua Philpot and shooting and hitting a third person walking by.During his testimony Tuesday, Pitoau tells the jury he didn’t intent on actually firing the gun. "When I see the gun it was like okay you know what I mean, just show it to these guys. It be like okay split parts, I run this way they run that way. It be cool," Pitoau said.Pitoau was asked by the defense attorney and prosecutor to recollect the night of August 7, 2017. The night he got into an altercation with the Philpot brothers and it ended in shots fired.RELATED: Suspect in Gaslamp shooting that injured off-duty deputy arrested in MexicoWhen Pitoau grabbed the gun from his friend that night he tells the jurors he didn’t think Jason Philpot in law enforcement and would know how to remove a gun from a shooter.“I had it in my right hand his left hand cam over my hand and his right hand came under my hand,” Pitoau continued. “So he grabbed the whole thing like he close don it so he started twisting my wrist." Pitoau went over the entire night and even included details of fleeing the country after he saw the shooting on the news the next morning. “I took off to Mexico, well I cut my hair, shaved my beard and then I walked to the trolley station and went to Mexico."After a month in Tijuana he was brought back to the United States and immediately handed over to U.S. Marshals. The retrial will continue Wednesday. 2143

SAN DIEGO (KGTV) - Sunday, doctors revealed President Donald Trump is taking a steroid, called Dexamethasone, as the latest medication for his coronavirus treatment."We just don't know what's going to happen next, things are very unpredictable," Dr. Christian Ramers, Chief of Population Health at Family Health Centers, said.Ramers has seen thousands of COVID-19 patients and says the disease has two phases, virus production and inflammatory. He said the shift generally happens seven to ten days in."Once things kind of shift, the damage actually comes more from the immune system's response than the virus itself," Ramers said, which is why a steroid like Dexamethasone is prescribed."Where it showed a decrease in mortality was in people who already required oxygen or if they were even sicker than that and were on ventilation," said Ramers, citing a study.Sunday, doctors stated the president received oxygen Friday before being taken to Walter Reed Medical Center, but said his oxygen levels only dipped to 94% and 93%. Normal levels are 95% and above.Ramers said studies show if you give the steroid too early or to someone who has a mild case, it could cause harm. "If you dial down the immune system too early or in a case that is really mild, you might have the opposite effect you're looking for," Ramers said.There's also a list of side effects."If you use them for a chronic basis or for more than a couple of days there is a long list of things it can cause. They can make your bones thinner, it can give you high blood sugar, diabetes, it can make people have trouble sleeping," Ramers said.With the president, as in any case, Ramers said we need to keep watching, "watching very carefully to what's happening day by day, it's going to be very important especially in this 7-10 day period because things could take a turn at any moment."Ramers said there are experimental coronavirus drug trials coming to San Diego, click here for more information or to sign up. 1988

SAN DIEGO (KGTV) – Tens of thousands of jobs are on the line as Congress struggles to save the airline industry, but a new bill announced Friday is giving some aviation workers hope.For Dante Harris, it’s more than a job.“It's a career that I would never want to exchange for any other,” said Harris.In his 21 years as a flight attendant with United Airlines, he’s traveled to every corner of the world. Now, he’s among the tens of thousands laid off after Congress failed to pass a stimulus bill this weekHarris is the president of the Association of Flight Attendants-CWA Council 12 union stationed at LAX, which also serves San Diego and Seattle members.He says about 2,500 United Airlines workers on the west coast lost their income and health care.It comes as an incredibly hard blow for the first responders of the sky who already faced countless challenges due to COVID-19.“We provide service to make sure that doctors and nurses get to where they need to go, to make sure that Americans are safe,” said Harris.On Friday, House Speaker Nancy Pelosi said if a bipartisan agreement is not reached, she’ll push for a standalone bill to extend payroll protections for airline workers for another six months.Harris is calling on Washington to extend that crucial funding so airline workers can get their wings back.“We need that bridge to get us to the point where we can bounce back,” said Harris. “And we can fly America to all corners of the earth again.” 1468

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