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SAN DIEGO (KGTV) — County public health officials say the first shipment of a potential coronavirus vaccine from drug company Pfizer will only cover about 70% of the first group of recipients identified in Phase 1.The CDC's Advisory Committee on Immunization Practices (ACIP) recommends that Phase 1A of vaccine distribution covers health care workers, and residents and workers of nursing homes and long-term care facilities:On top of that distribution structure, ACIP also split Phase 1A into three tiers to prioritize which groups of health care workers will receive a vaccine first:Tier 1:Acute care, psychiatric, and correction facility hospitalsSkilled nursing facilities, assisted living facilities, and similar settings for older or medically vulnerable individualsInclude residents in these settings as recommended for Phase 1A and ACIPParamedics, EMTs, and others providing emergency medical servicesDialysis centersTier 2:Intermediate care, for persons who need non-continuous nursing supervision, and supportive careHome health care and in-home supportive servicesCommunity health workers, including promotorasPublic health field staffPrimary care clinics, including Federally Qualified Health Centers, Rural Health Centers, correctional facility clinics, and urgent care clinicsTier 3:Other setting and health care workings, including specialty clinics, laboratory workers, dental/oral health clinics, pharmacy staff not working in settings at higher tiersAccording to San Diego County Public Health Officer Dr. Wilma Wooten, the county will only receive enough doses to cover about 70% of one group in the first tier of Phase 1A."We are not even getting enough doses for that first dot point in tier one," Wooten said, referring to acute care, psychiatric, and correction facility hospitals. "We are basically getting just over 70%."RELATED: What the FDA's review reveals about Pfizer's COVID-19 vaccineSan Diego County is expected to receive 28,275 doses of California's first allocation of 327,000 vaccine doses in mid-December. Wooten said there is about 39,000 personnel in the acute care hospital section alone."We anticipate that sometime next week, early next week, if not, on the weekend even, that we will get vaccines," Wooten said.She added that those first vaccines will be distributed to three "prepositioned locations" in the county. 2369

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) – As hospitals across San Diego prepare to distribute the COVID-19 vaccine to front line workers, questions have been raised about whether receiving the vaccine will be mandated for healthcare employees.“We will not make the vaccine mandatory. We do not make the normal flu vaccine mandatory. We do, however, require our staff to continue to wear masks throughout the entire flu season if they chose to not get the flu vaccine,” Palomar Health CEO Diane Hansen told ABC10 News. She said that Palomar Health’s policy will be no different with the COVID-19 vaccine.On Monday, ABC10 News spoke to hospital representatives at Sharp Healthcare, Scripps Health and Kaiser Permanente. They echoed Palomar Health's policy in that the COVID-19 vaccine will not be mandated but workers who decline to get it must wear PPE.San Diego employment attorney and legal analyst Dan Eaton told ABC10 News on Monday that hospitals can impose a mandate but so far that hasn't happened. “Employers generally have the legal right to mandate vaccination in the private workplace, subject to accommodations for medical conditions and religious objections, but there is a broader ethical question about whether they ought to mandate vaccination,” he said. He explained that the concern becomes whether mandating a resistant population creates a morale problem. “[The question is] whether, at the end of the day, you're acting in a nurturing fashion toward your employees if you mandate a vaccination that they don't want or they don't trust.”Eaton said it may be that at some point the state or federal legislature steps in in some form or fashion with respect to mandatory vaccination, but that's not the current case. 1718

SAN DIEGO (KGTV) -- Celebrity Chef Brian Malarkey announced Sunday the closure of his San Diego restaurants amid the coronavirus outbreak. The announcement was made on Instagram and the closures take effect Sunday, March 15. “On behalf of our staff and community and in the interest of keeping our city safe, we are temporarily suspending our operations,” Malarkey said. Along with his business partner Christopher Puffer, Malarkey operates several popular San Diego restaurants.RELATED: What's been canceled, postponed in San Diego, nationally due to coronavirusSome of the popular venues include Herb & Wood in Little Italy, Herb & Eatery, also in Little Italy, Herb & Sea in Encinitas, and Animae in downtown San Diego. “We’re looking forward to better days as soon as possible, and we’ll be back better and stronger than ever before. Thank you for your support, San Diego, we love you,” Malarkey added. Shortly after the announcement was made, Malarkey posted a photo of Herb & Eatery employees happily taking home food due to the closures. RELATED: Districts across San Diego County closing schools amid coronavirus outbreak“Sending all the food home with our incredible staff,” Malarkey wrote. The news follows an extensive list of closures announced throughout San Diego and Southern California as the state braces for COVID-19. 1360

SAN DIEGO (KGTV) -- County health officials have identified the woman who may have come into contact with a bat that tested positive for rabies at the San Diego Zoo Safari Park.According to the County of San Diego Health and Human Services Agency, one person, and possible others, were exposed to rabies on September 6.The county says a bat was seen flying around a previously unidentified woman around 11:30 a.m. at the Mombasa Cooker at Nairobi Village.The bat was later collected and submitted to health officials for testing. It was later determined that the bat was infected with rabies.The agency says the bat wasn’t part of the park’s collection of animals."Any other visitors who may have come in direct contact with a bat at the location and time described below should contact County Health and Human Services," the agency said. 847