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COVID-19 Update: The San Diego County Public Health Department has confirmed that a graduate student living off campus tested positive for COVID-19. Based on circumstances, the SDCPHD informed @uofsandiego no individuals on campus have been exposed by this student to COVID-19.— USD (@uofsandiego) March 14, 2020 327

Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

Cyberbullying among kids related to the election is a growing problem right now. And with how divisive things are, there are concerns this won't be going away after the polls close next week.“This is a very, very polarizing and almost even more in front of kids’ faces, election than any other time in history,” said Titania Jordan with Bark Technologies.Bark Technologies currently monitors more than 5 million kids online at home. Its monitoring shows from mid-August to the end of September, there was a 25% increase in bullying overall from the beginning of July. And there was a 220% increase in severe bullying.You'd expect to see this with the start of the school year, but the numbers show this is about a 50% increase from what Bark typically sees over this period.They say the feedback they've received from parents supports the increase with a direct tie-in to election-related cyberbullying.“It’s not something that she gets to judge over or bully over or make people feel bad about,” said Kathryn Noble, whose daughter was impacted by cyberbullying. “That's not acceptable at any age but especially at 13.”Noble says her 13-year-old daughter recently blocked one of her friends on social media over them supporting a different candidate than her.Bark found around 45% of what kids are sharing is memes about the two candidates. They've found this month that messages including the word “Trump” are being flagged more frequently for depression, hate speech and weapons.Messages including the word "Biden" are being flagged more frequently for cyberbullying, because they include disparaging or belittling language.“They're being bullied even because of maybe something their parents have said or something their family says,” said Matt McKee at Bark Technologies. “Hey, this is where we stand right now and because of that, kids are being brought into those situations.”As far as addressing this cyberbullying, the tech experts we talked with say asking your kids to teach you about a certain app they are using will give you more insight into what's happening earlier.Things to watch for include changes in sleep patterns or behavior. They also say now is really the time to encourage empathy with your kids. 2229

Cleveland Browns coach Hue Jackson is keeping a promise he made to fans to jump into Lake ErieIn 2016, Jackson told fans he would jump in the lake if the Browns went 1-15 again. After a winless 2017 season, Jackson boldly declared he would keep his promise. 265

CINCINNATI, Ohio - Among the sea of cardboard cut-out faces propped up in stands at MLB stadiums across the country is one specific face, present for teams he was never able to see play in person.Joaquin Oliver, his face among those in the crowds at Great American Ballpark in Ohio and 13 other MLB stadiums, was 17 when he was shot and killed in the mass shooting at Marjory Stoneman Douglas High School in Parkland, Florida in 2018. His father, Manuel, purchased cutouts in several different baseball stadiums to support his son's love of baseball and to make a statement about gun violence."I am not a baseball fan, so I was learning everything from him, and I was also creating those moments," said Manuel.Joaquin grew up loving baseball. His father loved the quality time the sport gave them together."I just want everybody to understand that life is about magic moments," said Manuel. "And going to the ballpark with your kids is such a magic moment."Manuel said he hopes fans who see the cutout of his son at GABP and other stadiums will be inspired to do something about gun violence, whether that be through voting, educating themselves, or joining an organization.He also founded Change the Ref, an organization that works to inspire a younger generation to help lead the way to change toward a more peaceful future. Manuel himself continues to work to raise awareness about the Parkland shooting and speaks out against what he calls a "corrupt" gun lobby and the politicians he believes its influences."I'm begging you to do something to prevent that from happening," said Manuel. "And you won't regret doing something, by the way. It can only be better. It can't be worse."This story was first reported by Josh Bazan at WCPO in Cincinnati, Ohio. 1765