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TIANJIN, April 16 (Xinhua) -- As China tries to establish a universal medicare umbrella, its first move to offer treatment to all the hemophilia patients in the country is to know their population and where they are.China's national hemophilia information management center registered 7,980 cases nationwide since its establishment last year in a bid to provide reference for making national treatment policies and medicine production quota, said the center officials Saturday.Yang Renchi with the center and the Chinese Academy of Medical Sciences, said that the patient information database will help the government make hemophilia-related medical and social welfare policies, optimize resources and guide the manufacturing of drugs such as coagulation factor VIII.The information center, created by the Ministry of Health, is located in the Blood Diseases Hospital of the Chinese Academy of Medical Sciences in the port city Tianjin in north China.Hemophilia is a rare genetic bleeding disorder that prevents the blood from clotting properly, resulting in easy bruising and prolonged bleeding from trauma. Lack of treatment can lead to permanent disabilities or even death.China is estimated to have roughly 100,000 hemophilia patients."Be inspired; get involved in Treatment for All" is the theme for the 22nd World Hemophilia Day, which falls on Sunday, April 17."A necessary precondition for 'Treatment for All' is to know the clinical information and location of each case," said Yang, "and this is exactly what the information system does."In addition, China plans to establish hospital-based provincial hemophilia management centers within five years across the country to register and monitor patients and standardize disease diagnosis and treatment under the information system.SHORTAGE OF DRUGSBlood-derived coagulation factor VIII and recombinant coagulation factor VIII are two effective drugs which are vital for hemophiliacs. However, the drugs are expensive and produced in limited quantities, a difficulty which hundreds of thousands of hemophiliacs in China have to confront.According to Yang, the minimum dose of coagulation factor VIII for prevention of bleeding episodes is two international units (IU) per kg of weight a day. A 50-kg hemophilia patient needs at least 36,500 IU of factor VIII every year to prevent bleeding."Each IU of blood-derived coagulation factor VIII costs about 3 yuan(0.46 U.S. dollars) and the annual cost is almost 120,000 yuan. The recombinant one is almost twice the price," said Yang.Only four drug firms are qualified to manufacture blood-derived coagulation factor VIII in China. The national output in 2010 was 400,000 vials (200 IU per vial) which means 80 million IU for the entire country.Wu Runhui, a hematology specialist with the Beijing Children's Hospital, said that the minimum dose is only for the prevention of bleeding episodes which are required to keep the patient alive. For the hemophiliac to live a regular lifestyle, 3,000 IU per kilo a year is needed, which would cost half a million yuan a year."Even in the most developed countries, a hemophiliac cannot survive without supportive medical policies and social welfare system," said Wu.
LOS ANGELES, April 20 (Xinhua) -- Hundreds of homes were evacuated on Wednesday in Monument, U.S. state of Colorado after hydrochloric acid was leaking from a train car, authorities said.The leak was first reported around 1 a.m. local time when a southbound train spotted a vapor trail on a northbound train, the Denver Post reported.Authorities first ordered the evacuation of some 255 homes, and later expanded the evacuation to an additional 160 homes, according to the report.Schools in the area were closed due to the leaking, the report said.A specialized crew from Texas has been dispatched to the scene to transfer the hydrochloric acid leaking from the train car and is expected to finish the job in four or five hours, weather permitting, the report quoted Sgt. Mike Schaller of the El Paso County Sheriff's Office as saying.The leak is contained but hydrochloric acid is still leaking slowly from the tanker, which holds 25,000-30,000 gallons, Schaller said.He said police went door-to-door notifying residents of a subdivision adjacent to the railroad tracks to evacuate as a precaution.No injuries have been reported, he said, but residents have been warned that they may have to be out of their homes until Friday as hazardous material crews offload the acid to another container.The northbound train originated in Kansas and was en route to Denver at the time, the Denver Post said.It's not yet known how much hydrochloric acid leaked from the train car.Once the leak is sealed, crews will remove the hydrochloric acid from the damaged car to a new car that will likely continue into Denver, according to the report.Monument is a town of 3,230 residents 88 kilometers south of Denver.

WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.
MOSCOW, May 24 (Xinhua) -- Russia's Soyuz TMA-20 spacecraft with three crew members onboard has landed in Kazakhstan on Tuesday, said the Mission Control Center (MCC) outside Moscow.The spacecraft undocked from the International Space Station early Tuesday, carrying Russian cosmonaut Dmitry Kondratyev, European Space Agency (ESA) astronaut Paolo Nespoli and NASA astronaut Catherine Coleman back to Earth.According to the center, the Soyuz TMA-20 landed in the Kazakh steppe at 6:27 Moscow time (0227 GMT). Some 17 planes and helicopters and several rescue vehicles had conducted search works.Flight engineers Catherine "Cady" Coleman of the U.S. (L) and Italian Paolo Nespoli (R), and Russian cosmonaut and station commander Dmitry Kondratyev are seen after the Soyuz capsule landed, about 150 km (93 miles) southeast of the Kazakh town of Zhezkazgan May 24, 2011. A Russian Soyuz capsule delivered an international trio of astronauts back to Earth on Tuesday after six months on the International Space Station, parachuting through clear skies toward a safe landing on the Kazakh steppe.Deputy head of Federal Medical and Biological Agency Vyacheslav Rogozhkin said Italian astronaut Naspoli had some health problem after landing."Two crew members are fine, the third one has some problems with his vestibular system," Rogozhkin told a press conference after the landing.In December, the Soyuz TMA-20 was launched from the Kazakh Baikonur space center with three crew members.The next launch of manned spacecraft to the ISS was scheduled in early June.
BEIJING, Feb. 3 (Xinhua) -- Chinese Foreign Ministry said here Thursday that almost all Chinese travellers stranded in Egypt had returned home by planes sent by the government.A total of 1,848 Chinese, including those from Hong Kong, Macao and Taiwan, had been flown back by Thursday afternoon, the ministry said in a statement.The Chinese government has organized eight flights from four Chinese airline companies to Egypt since Jan. 31.The last two planes, belonging to China Eastern Airlines, returned to Beijing from Egypt Thursday, bringing back a total of 431 Chinese citizens, according to the ministry.
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