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WASHINGTON, July 7 (Xinhua) -- Space shuttle Atlantis will soar into the sky Friday on NASA's 135th and final flight. Its scheduled return to Earth later this month will mark the end of NASA's 30-year space program.Since its onset with the launch of space shuttle Columbia, the program has been seen as a cheap, safe and reliable way for space exploration.Despite its great contributions to U.S. manned space flight, it has also left some grave and tragic lessons, making its termination inevitable.HIKING COSTSLaunched in 1972 by then President Richard Nixon, the shuttle program aimed to provide a new system of affordable space travel and proved to be NASA's most enduring project in its 50 years of existence.In 1981, shuttle Columbia made its first shuttle flight for two days. It was the ultimate hybrid and the first reusable spacecraft.Launched like a rocket and gliding back to Earth like an airplane, space shuttles not only can act as a space taxi to carry astronauts, but have the muscle of a long-distance trucker to haul heavy machinery.The spaceship boasts more than 3,500 subsystems and 2.5 million parts and is nine times faster than a speeding bullet as it climbs heavenward. That versatility, however, has translated into higher costs.NASA originally estimated the program would cost about 90 billion U.S. dollars. However, its actual cost stands at about 200 billion dollars, compared with the 151 billion dollars spent on Apollo which took Americans to the moon in 1969.In an article in Technology Review, John Logsdon, former head of the Space Policy Institute at George Washington University, drew a direct connection between the ravenous shuttle budget and the lack of other large advances in manned space flight."By operating the system for 30 years, with its high costs and high risk, rather than replacing it with a less expensive, less risky second-generation system, NASA compounded the original mistake of developing the most ambitious version of the vehicle," he wrote."The shuttle's cost has been an obstacle to NASA starting other major projects," he added.HIGH RISKIn terms of safety, the shuttles have never been as reliable as their designers had envisioned.On average, one out of every 67 flights ended up with fatal accidents. Based on the rate of deaths per million miles traveled, the space shuttle is 138 times riskier than a passenger jet.Seven astronauts onboard died when Challenger exploded about a minute after launch in 1986. Nearly two decades after the tragic blast, a new catastrophe descended when the shuttle Columbia disintegrated moments before landing in 2003, killing another seven spacemen.Again, the shuttle program was shelved for more than two years as NASA stepped up efforts to make it safer. But experts say the fundamental problem related to shuttles' safety cannot be solved due to their "birth defects.""It is in the nation's interest to replace the Shuttle as soon as possible," concluded the panel that investigated the 2003 Columbia accident.

UNITED NATIONS, June 9 (Xinhua) -- China on Thursday called for governments, organizations and individuals to take active actions, enhance solidarity and establish joint prevention and treatment mechanism to deal with AIDS.Yin Li, vice Health minister of China made the remarks as he addressed the United Nations High-Level Meeting on HIV/AIDS held here."As a responsible developing country, the Chinese government has actively fulfilled its commitments in achieving universal access to AIDS prevention and treatment, eliminating social discrimination, and ensuring rights to prevention, treatment and care of people living with HIV/AIDS and their families," he said.Thanks to the efforts over the years, the spread of AIDS epidemic in China has slowed down, the morality rate considerably decreased and life quality of people with HIV/AIDS has significantly improved, Yin added.In order to achieve the goal of zero new HIV infections, zero discrimination and zero AIDS-related deaths defined by the joint UN Program on HIV/AIDS (UNAIDS), China called for all countries, organizations and persons to be mobilized, further enhance solidarity and clearly define responsibilities and establish a joint prevention and treatment mechanism.Yin said that in the face of the common challenge of HIV/AIDS, the developed and developing countries must assume shared responsibilities."The developed countries should further provide developing countries with generous, unconditional financial and technical support. The developing countries should give the same priority to AIDS control as economic development, explore the models of prevention and treatment consistent with their national conditions, " he said.In addition, the private sector and relevant organizations should assume more responsibilities. On one hand, efforts should be made to mobilize more resources in better implementing prevention, treatment and care measures; on the other hand, multinational drug manufactures should reduce drugs and testing equipment prices through technology transfer, contract manufacturing and reduction of monopoly profits in order to provide universal access to treatment services, according to Yin.Yin stressed that the Chinese government would strengthen its working mechanism, enhance coordination across sectors and participation by the entire society, continue to actively participate in global fight against AIDS, assume its responsibilities and obligations so as to make contribution to achieving the goal of global AIDS control.

BEIJING, Aug. 12 (Xinhuanet) -- The risk of developing coronary heart disease is 25 percent higher for women smokers compared with men, according to a study published in the British medical journal "The Lancet".The authors say this could be due to the physiological differences between the sexes with cigarette smoke toxins having a more potent effect on women.The study by Dr Rachel R Huxley from the University of Minnesota and Dr Mark Woodward from Johns Hopkins University involved a meta-analysis of around four million individuals and 67,000 coronary heart disease events from 86 studies.The researchers found that the pooled adjusted female-to-male relative risk ratio (RRR) of smoking compared with not smoking for coronary heart disease (CHD) was 1.25 (25 percent) higher for women.This RRR increased by 2 percent for every additional year of follow-up, meaning that the longer a woman smokes, the higher her risk of developing CHD becomes compared with a man who has smoked the same length of time.The authors say, "The finding lends support to the idea of a pathophysiological basis for the sex difference. For example, women might extract a greater quantity of carcinogens and other toxic agents from the same number of cigarettes than men. This occurrence could explain why women who smoke have double the risk of lung cancer compared with their male counterparts."Worldwide, there are 1.1 billion smokers, of whom a fifth are women.According to the Tobacco Atlas, India, with around a crore female smokers, ranks third in the top 20 female smoking populations across the globe, only the U.S. with 2.3 crore female smokers and China with 1.3 crore female smokers, are worse off.

BEIJING, August 1 (Xinhuanet) -- U.S. researchers have discovered a genetic mutation unique to African Americans that links to heighten their asthma risk, according to reports published on Sunday in the journal Nature Genetics.Researchers of University of Chicago found a gene, PYHIN1, and its variations may account for asthma risk in people of African descent. In their study, they examined data from nine previous genome-wide association studies, totaling more than 2 million single nucleotide polymorphisms in 3,246 asthma patients and 3,385 control patient, 1,702 patient-parent groupings, 355 family-based cases, and 468 family-based controls.In the study, the researchers found that between 26 percent and 29 percent of people of African-descent carried at least one copy of the gene.  In particular, one polymorphism of the gene was 34 percent more likely found in African-American and Afro-Caribbean people with asthma.  More interestingly, this variant of the gene is rarely found in Caucasian people and in Latino population, it was found in less than 5 percent.This new variant is part of a family of genes linked with the body's response to viral infections. It is thought to be involved in interferon signaling, which could influence the occurrence of asthma.The team stressed that each gene variant on its own plays only a small role in increasing asthma risk, but that risk could be multiplied when combined with other risk genes and with environmental factors.

WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.