濮阳东方医院男科看早泄口碑很好濮阳东方非常可靠,濮阳东方医院看妇科收费很低,濮阳市东方医院收费高不高,濮阳东方医院看早泄非常好,濮阳东方医院妇科技术权威,濮阳东方妇科收费咨询,濮阳市东方医院技术非常哇塞

Last year's seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, then, people had inadequate protection against the flu.This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today.This year's flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate professor at the University of Pennsylvania. Add to that, he said, "this could end up being a pretty bad flu season."Still, he said, "our best protection" against severe illness is getting vaccinated with the flu shot we have today.Finding answersEach year before flu season begins, a vaccine is made based on whichever virus strains are expected to circulate. The selected seed strains are distributed to vaccine manufacturers which then produce their formulations and make them available to health care professionals before the season begins.During the 2015-16 season, vaccine effectiveness was 47%, while for the previous 2014-15 season, effectiveness was just 19%, according to the CDC. While the overall effectiveness of last season's vaccine was 42%, it was only 34% effective against the H3N2 viruses that dominated the season.Vaccine effectiveness varies based on how well it matches the circulating virus strains. Sometimes, a vaccine corresponds to the predominant virus yet its effectiveness is still not what scientists would expect. Trying to understand which element of the vaccine failed is difficult.Hensley and his team began their investigation of last year's vaccine by looking at the seed strains that had been distributed to vaccine manufacturers. These seed strains had been propagated in chicken eggs, the common method used today."The sequences of these viruses are available and when we did an alignment to see what the sequence of these vaccines were compared to the viruses that were circulating, it became very obvious that there was this mutation," said Hensley.To see the effects of the mutation, the team next looked at how the immune systems of both animals and humans who'd been inoculated with an egg-based flu vaccine responded to the actual circulating viruses.The antibodies -- immune system proteins that fight invading pathogens -- elicited in both animals and humans failed to bind to and neutralize the flu viruses, Hensley and his colleagues found.While most vaccines in the United States are made in chicken eggs, a small fraction are produced in insects or mammalian cells, Hensley explained. (These are given to people with egg allergies.) He and his team compared immune responses in animals and humans who had received a cell-based vaccine -- in this case, Flublok made by Protein Sciences Corporation."And we found both animals and humans receiving that (cell-based) vaccine had superior antibody responses that could bind and neutralize these circulating H3N2 strains," said Hensley.Making a better vaccine"Most of the infrastructure to produce vaccines in the US is based on chicken eggs," said Hensley. There are good reasons for this, including the fact that egg-based propagation allows manufacturers to quickly produce large quantities of vaccine.While egg adaptations have always been a problem, beginning last year it had become a "huge problem," said Hensley. "As soon as you try to grow this virus in eggs, within a few hours, the virus will acquire this kind of mutation."This is not an easy problem to fix, he said. To produce vaccines in cells means "a very expensive process for companies to just change their overall manufacturing process," Hensley explained. "You can't really do that on the drop of a dime."Meanwhile, the same seed strains used last year are being used this year to make the current vaccine, said Hensley."This year may be especially difficult because, in addition to this egg adaptive mutation which was present last year, there's indication that the H3N2 viruses are actually evolving," said Hensley.Not only will the vaccine be a mismatch with the actual circulating viruses due to egg adaptation but the vaccine could also be a mismatch due to unexpected viral evolution.What kind of flu season is ahead?It's too early to speculate which viruses will become dominant in the United States over the course of the coming flu season, said Hensley, "but it's starting to look like it will be H3 viruses." H3 viruses are influenza A viruses."There are the A group of viruses and the B groups," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. "The A groups are the ones that usually are responsible for large epidemics ... whereas the B flu strains usually smolder along. They always cause illness -- it can be just as severe as the A strains -- but they don't produce large outbreaks."Though last year's vaccine was mostly ineffective in thwarting the flu, it still prevented nearly 30% of hospitalizations that might have resulted, according to CDC calculations. For older adults, that rate was even higher, at 37%. Plus, the vaccine reduced outpatient visits by 42% last season.The CDC advises everyone 6 months and older to get a flu shot, as only injectable flu vaccines are recommended. More than 130 million doses of flu vaccine have been distributed so far this year and flu activity is still low across the nation.It's still early days, but experts believe we may be facing a tough season, and not only because of vaccine concerns.The reason?Australia had a tough flu season this year, with a total of 215,280 laboratory-confirmed cases and 504 flu-associated deaths reported to its National Notifiable Diseases Surveillance System as of October 13, government data show. According to a surveillance system report, adults over the age of 80 and children between 5 and 9 years old have been most affected."In general, we get in our season what the Southern Hemisphere got in the season immediately preceding us," Dr. Anthony Fauci, director of the United States' National Institute of Allergy and Infectious Diseases, said in an interview last month.An "intelligent guess," therefore, is that the Northern Hemisphere, like the Southern Hemisphere, will likely battle more cases of the viral infection, he said, though "with influenza, it is never 100%.""If H3N2 viruses dominate the US flu season again this year, vaccine effectiveness will likely be moderate to low again," said Hensley.Still, he said, everyone should get their annual flu shot."The other components of the vaccine, like H1N1 and influenza B, will likely provide excellent protection," said Hensley. "The vaccine will also likely prevent severe disease and death caused by H3N2 viruses, even though this component of the vaccine is mismatched."  6969

LEMON GROVE, Calif. (KGTV) — Parents in Lemon Grove School District pulled their students from class Tuesday to protest against decisions being made, they say, without parent input. In March, 10News covered an emotional Lemon Grove school board meeting when parents fought to retain 16 teachers who had been designated for non-re-election. Those teachers chose to resign rather than have the designation placed on their permanent teaching records. The next regularly scheduled board meeting is Tuesday night, and parents plan to show up again to voice their complaints about the district, ranging from curriculum decisions, resource scarcity and student safety. One parent told 10News behavior issues are increasing in classrooms and the administration is failing to hold students accountable. A decline in classroom resources led her to pull one of her children from the district and enroll him in charter school. Several other parents at the rally say they have done the same, or are considering doing so, due to a variety of complaints. "We are not getting the basic resources and they are making decisions that don't make sense," says Rosa Carney. Tuesday's board meeting will be in open session at 6:00PM at Lemon Grove Library Community Room, 3001 School Lane, Lemon Grove. A spokesperson for the district sent us the following statement, outlining curriculum successes and resource allocation: 1409

LINDA VISTA, Calif. (KGTV) — Rose Donuts, which was forced to close its doors after its owner was killed in April, will reopen Saturday for the first time.Randy Taing, 58, died from injuries sustained in a home invasion robbery on April 8.He and his wife had run Rose Donuts for 25 years, turning it into a beloved community hot spot. But after his death, its future was uncertain.RELATED: Clairemont man dies after possible home invasionThat’s where Ken Chu comes in. He is related to the Taing family through his wife, though he didn’t realize it until Randy’s widow approached him to run the shop.He already owns another donut store in Serra Mesa, but said he felt compelled to take it on.“It was a mom and pop place and we want to keep it like that,” he said.RELATED: Fundraiser being held for San Diego donut shop owner who died after home invasion attackHe immediately went to work, taking the opportunity to update the shop, ordering new furniture and equipment.“We’re trying to get this grand opening going for tomorrow so people don’t think we went away and are never coming back,” he said.The store will open at 5 a.m. on May 25. The new operating hours will be from 5 a.m. to 12 p.m. every day. 1213

LA MESA (CNS) - The family of a grandmother who was struck in the face by a law enforcement projectile, suffering severe injuries, during a weekend police protest in La Mesa called Tuesday for the officer involved to be publicly identified, fired and charged with attempted murder.Cellphone video that has gone viral shows 59-year-old Leslie Furcron lying on the ground, blood streaming down her face, amid shouting demonstrators attending the Saturday evening protest against police brutality.Furcron remains hospitalized in an intensive-care unit in a medically induced coma and may lose one of her eyes, according to her family and their attorney. They held a news conference outside La Mesa City Hall to demand that the officer who fired the projectile, which struck her in the forehead, be held accountable.Dante Pride, an attorney representing the family, said he had reviewed dozens of videos and spoken with scores of people present at the protest outside La Mesa police headquarters and has seen no evidence that Furcron was violent or did anything to justify being shot.Furcron was holding up her cellphone, recording the protest, when an officer opened fire, Pride said. The other demonstrators also were being peaceful and received no warning from law enforcement before "the tear gas came and the bullets rained down," he said.Pride said he believes the involved officer purposely aimed at Furcron's head, in contradiction of the LMPD's rules regarding use of force, which he said hold that projectiles be aimed below the waist.It's uncertain whether the officer who opened fire was with the La Mesa Police Department or another agency, though Pride said he believes it was an LMPD officer.A representative of the San Diego County Sheriff's Department said the regional agency had no role in the shooting."It did not involve a sheriff's deputy," sheriff's public-affairs Lt. Ricardo Lopez said Tuesday afternoon.A La Mesa police spokesman did not return a telephone call seeking comment.Two of Furcron's sons, Ahmad and Azim, described their mother as a law- abiding La Mesa resident. Ahmad Furcron demanded that police hold their own accountable, as they would any other citizen."If I commit a crime, I'm going to jail, no ifs, ands or buts about it," he said. "Whoever that was needs to stand and (be) held accountable for it. That's attempted murder. My mom was shot between the eyes, 59 years old, protesting. She doesn't have the right to protest?"Pride called on the general public to demand that law enforcement officials release the name of the involved officer and asked anyone with video footage of the events surrounding the shooting to forward it to him.The lawyer added that if the department is unable to determine which officer fired the projectile, the incident still highlights issues with police practices regarding crowd dispersals."We need something different," Pride said. "There should never be a case where a police unit can fire indiscriminately into a crowd and not know what they're shooting at and who they're shooting at."A GoFundMe.com page has been created for Furcron, with more than ,000 raised by late Tuesday afternoon. Pride said they expect her medical bills to near million when all is said and done.The page can be viewed online here. 3299

LAKESIDE, Calif. (KGTV) -- The forward rate of spread of a Lakeside brush fire has been stopped, Cal Fire said. The announcement comes after the San Diego Sheriff's Department evacuated 14402-14470 Willow Road as the blaze threatened homes Wednesday afternoon. Evacuations were lifted shortly after 3:30 p.m.According to the Cal Fire, the fire sparked around 12:40 p.m. near the 14000 block of Willow Road. Crews were quickly able to stop of spread of the original fire, but a second, larger fire erupted about 15 minutes later.In total, the blaze scorched 52 acres and, as of Wednesday night, was 100 percent contained. #WillowFire in Lakeside [final] All units available. The fire is 100% contained after burning 52 acres.— CAL FIRE/SAN DIEGO COUNTY FIRE (@CALFIRESANDIEGO) September 26, 2019 RELATED: Check today's forecastThe blaze comes as moisture is set to move into the county Wednesday with a chance for showers and thunderstorms. "While there is a slight chance for a few showers this afternoon, most activity will hold off until this evening with peak activity tonight through tomorrow morning," said 10News Meteorologist Megan Parry. 1154