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WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.

BEIJING, Jan. 1 (Xinhua) -- The public on Sunday strongly echoed Chinese President Hu Jintao's New Year address broadcast on Saturday, vowing to make great efforts for rejuvenation of the nation, a better future.In his speech titled "Jointly Improve World Peace and Development," Hu said that China will continue to develop friendly exchanges with other countries and positively participate in international cooperation on global issues.The country will continue to balance maintaining steady and relatively fast economic growth with adjusting its economic structures and managing inflation expectations, Hu said in the speech.PROUD Of COUNTRY'S ACHIEVEMENTS"We have been encouraged by President Hu's address, said Wang Laihua, head of the public opinions research institute of Tianjin Social Sciences Academy."His address summarized the achievements that we have made in the first year of the 12th Five-Year Plan, which raised people's expectation for prosperity, happiness," said Wang.Hu said in the address that in the face of complicated international situations and arduous tasks in maintaining domestic reform, development and stability in 2011, Chinese people united and continued to push forward the opening up and reform drive and the socialist modernization construction, while maintaining steady and relatively fast economic growth and making progress in building a well-off society in an all-around way.Zhu Jianfang, chief economist of CITIC Securities, said that the country's macroeconomic control has made positive achievements in the last year, as the prices of properties and commodity have been effectively controlled."We feel reassured after hearing Hu's speech," said Wen Jun, who has come to south China's Guangzhou for business from Hong Kong for 16 years, referring to Hu's speech saying that China will stick to the guidelines of "one country, two systems," "Hong Kong people governing Hong Kong," "Macao people governing Macao," and a high degree of autonomy in maintaining the long-term prosperity and stability of Hong Kong and Macao.

WASHINGTON, Nov. 24 (Xinhua) -- An inexpensive drug that treats Type 2 diabetes has been shown to prevent a number of natural and man-made chemicals from stimulating the growth of breast cancer cells, according to a newly published study by a Michigan State University researcher. The research, led by pediatrics professor James Trosko and colleagues from South Korea's Seoul National University, provides biological evidence for previously reported epidemiological surveys that long-term use of the drug metformin for Type 2 diabetes reduces the risk of diabetes-associated cancers, such as breast cancers.The research appeared online this week in PLoS One.For the study, Trosko and colleagues focused on the concept that cancers originate from adult human stem cells and that there are many natural and man-made chemicals that enhance the growth of breast cancer cells. Using culture dishes, they grew miniature human breast tumors, or mammospheres, that activated a certain stem cell gene. Then the mammospheres were exposed to natural estrogen -- a known growth factor and potential breast tumor promoter -- and man-made chemicals that are known to promote tumors or disrupt the endocrine system.The team found that estrogen and the chemicals caused the mammospheres to increase in numbers and size. However, with metformin added, the numbers and size of the mammospheres were dramatically reduced. While each of the chemicals enhanced growth by different means, metformin seemed to be able to inhibit their stimulated growth in all cases."While future studies are needed to understand the exact mechanism by which metformin works to reduce the growth of breast cancers, this study reveals the need to determine if the drug might be used as a preventive drug and for individuals who have no indication of any existing cancers," Trosko said.

BEIJING, Oct. 29 (Xinhua) -- Chinese Premier Wen Jiabao and Chairman of the Central Military Commission Hu Jintao Saturday issued an order to publicize the Regulations on Resettlement of Ex-Servicemen, which will take effect from Nov. 1.Formulated with an aim to protect the legitimate rights and interests of ex-servicemen, the 53-article document highlights a series of initiatives designed for the appropriate placement of veterans.State organs, social groups, enterprises and public institutions should give preferential treatment to ex-servicemen while recruiting staff members or contract workers, according to the regulations.The regulations provide that demobilized soldiers who register for a civil servant examination or apply for a position in government institutions will be given preference.Those companies or organizations which recruit retired soldiers will enjoy favorable policies prescribed by current laws and regulations.

BEIJING, Sept. 30 (Xinhuanet) -- Miners, construction workers and people in hotel and food service industry are most likely to smoke in the U.S., according to new research finding.The finding was contained in a report released Thursday by the U.S. Centers for Disease Control and Prevention (CDC).According to the finding, miners and people in hotel and food service have a cigarette smoking rate of 30 percent, followed closely by construction workers' 29.7 percent.Both rates are much higher than the average smoking rate of 19.6 percent among all U.S. working adults.Workers in the education services industry have the lowest smoking rate, with 9.7 percent, followed by the 10.9 percent of workers in company management, the report said.Low education levels are a factor in high smoking rates, along with poverty and gender, said Ann Malarcher, senior scientific adviser at the CDC."Although some progress has been made in reducing smoking prevalence among working adults," the report wrote, "additional effective employer interventions need to be implemented."Smoking kills an estimated 443,000 each year in the U.S., costing about 193 billion U.S. dollars annually in direct health care expenses and productivity loss.

来源：资阳报