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SAN DIEGO (KGTV) - PhaseBio, a company based out of San Diego and Pennsylvania, announced it would be starting a clinical trial for a drug that could help keep severe COVID-19 patients from needing a ventilator. “If you are infected with coronavirus and you’re admitted to hospital, we’re trying to catch those patients before they have a rapid decline and prevent intubation or other more severe complications of the coronavirus,” said Jonathan Mow, CEO of PhaseBio. The drug is called PB1046 and is a “novel, once-weekly, subcutaneously-injected vasoactive intestinal peptide (VIP) receptor.” It was originally being researched for use on patients with high blood pressure, said Mow. But they pivoted when they realized it might have properties that could help prevent acute respiratory distress syndrome (ARDS), a potentially deadly condition caused by the inflammation of the lungs due to the body’s immune response to the coronavirus. “We realized that the characteristics of our drug fit nicely to what we would want to control in the complications in coronavirus patients,” said Mow. The clinical trial will take place at 20 different locations and involve about 210 subjects who have been hospitalized and require oxygen, but have not been intubated. Mow said they hope to publish the results of the trial by the end of the year. 1345

SAN DIEGO (KGTV) - One of San Diego's hottest restaurant groups is suing the City of San Diego, in part, for negligence. The owner of Little Italy’s The Crack Shack and Juniper & Ivy gave 10 News an exclusive interview regarding allegations that the city failed to remedy issues which led to last summer’s massive water main break that flooded much of the area. “It seems the city is using a ‘whack-a-mole’ approach,” says restaurant owner Michael Rosen when asked about the city’s way of addressing underground piping issues.  Rosen’s Juniper Hospitality restaurant group in suing the city for negligence, negligent interference with economic advantage and prospective economic advantage, and inverse condemnation. According to the recently filed lawsuit, before the July water main break, “…the defendants were working within the area and had left temporary water pipes above ground, which were being run over by hundreds of cars a day, for approximately six months with no further attempt to repair or remove…The Defendants issued a ‘quick fix’ to the problem in lieu of fixing the unstable water main which resulted in the massive rupture that occurred.” “This is what happens when you ignore a problem for so many months,” he tells 10 News. Rosen claims more than 400 reservations had to be canceled. “We likely lost 30 to 40 thousand dollars in revenue for the day and it was a very busy day,” he adds. “It’s just mind-boggling,” says Adam Babin of Power Keg Athletics. Babin’s CrossFit studio was destroyed beyond repair. He believes he lost more than 0,000 in property, alone. “Hands down, this was the toughest and most mentally and emotionally [difficult] situations I've ever had to deal with in my life,” he adds.  “It definitely hurt my business for sure,” says Rebecca Hyde-Edwards of Hyde Edwards Salon and Spa. Hyde-Edwards, Babin and Rosen say they have yet to receive adequate responses from the city after submitting their damage claims.  "This is a destination area and [the city] should look out for all the businesses that make it what it is,” adds Hyde-Edwards. A City of San Diego spokesperson tells 10News the city has received 28 claims and paid out .5 million to date. Only 3 of the 28 claims have been resolved. It reports that claimants have not submitted all of the supporting documentation, so not all claims have been paid. Timeframes for payments are reportedly done on a case by case basis and vary depending upon when all the supporting documentation is received and evaluated by the City.  The city’s aging water system infrastructure has wreaked havoc. More than 0 million have been spent in the last 5 years to repair and replace more than 100 miles of piping. Rosen tells 10News he’d be happy to drop his lawsuit if the city had a comprehensive plan to fix Little Italy’s crumbling piping. “It’s our expectation and justifiable fear that we'll have to close many days in the future unless this is really addressed,” he says of his restaurants.  A city spokesperson reports the broken section of pipe in Little Italy was immediately replaced after the flooding. The city’s 0.95 mile pipeline replacement project in that area was reportedly completed last summer. A spokesperson for the city says there are no additional plans for pipeline repairs or replacement for that immediate area.  The city will not respond to the lawsuit. It reports it doesn't comment on pending litigation.  Visit Group Job 954 for a closer look at the project being referenced in this story. The  CIP Project Map Viewer has the status of city projects in your area, which can be searched by address.    3797

SAN DIEGO (KGTV) — On Monday, a planetary sight unseen for nearly 800 years will captivate stargazers as Jupiter and Saturn create a celestial event known as the "Christmas Star."The two bright planets will align to create an even brighter display, culminating on the night of Monday, Dec. 21, according to NASA. While the two planets pass each other regularly, this year's event is so rare because not only is the distance between the planets so close but it's also occurring at night."You can imagine the solar system to be a racetrack, with each of the planets as a runner in their own lane and the Earth toward the center of the stadium," said Henry Throop, astronomer in the Planetary Science Division at NASA Headquarters in Washington. "From our vantage point, we’ll be able to be to see Jupiter on the inside lane, approaching Saturn all month and finally overtaking it on December 21."The closest alignment will last for a few days and appear just a tenth of a degree apart. On Monday, Jupiter and Saturn will appear so close that a pinkie finger at arm’s length will easily cover both planets.The planets haven't passed this closely in 400 years, and it's been nearly 800 years since this "Great Conjunction" has occurred at night, NASA says."Conjunctions like this could happen on any day of the year, depending on where the planets are in their orbits," said Throop. "The date of the conjunction is determined by the positions of Jupiter, Saturn, and the Earth in their paths around the Sun, while the date of the solstice is determined by the tilt of Earth’s axis. The solstice is the longest night of the year, so this rare coincidence will give people a great chance to go outside and see the solar system."HOW TO SEE ITIn San Diego County, viewers can see the planets without needing a telescope by looking toward the southwest horizon just after sunset, NASA says, but a pair of binoculars or a small telescope will only enhance the view. The best way to see the phenomenon is by finding an unobstructed view of the sky from say a park or field. The sight should even be viewable from most cities, but the site will only be visible after sunset for about one to two hours.To tell the two planets apart prior to Monday when they switch positions in the sky, Jupiter will look like a bright star and be easily seen, while Saturn will look slightly fainter and slightly above and to the left of Jupiter.For photographers, NASA recommends using a long exposure time to take in enough light as it gets dark. Both cell phone camera and DSLR camera users are encouraged to use a tripod to reduce any shaking during a long exposure.Cell phone users may even want to use "night mode" or a wide-angle lens if available. DSLR users may consider setting their focus to manual and leaving their aperture wide open to let in as much light as possible.Jupiter and Saturn should be bright enough to allow photographers to capture the planets without needing to zoom, NASA says. More of NASA's photography tips can be found online here. 3044

SAN DIEGO (KGTV) - Police have confirmed that the 19-year-old woman shot near Sunset Cliffs Thursday morning was targeted. Police told 10News they received a call at about 7:10 a.m. from a person who spotted a bleeding woman lying on a staircase next to the beach off Ladera Street, near Sunset Cliffs Boulevard.Responding officers arrived and found the woman with multiple gunshot wounds.The 19-year-old was taken to UC San Diego Medical Center. Police said Thursday afternoon that the woman is in stable condition and was able to tell police she had no idea what happened.Police said they do not have any information on a suspected shooter at this time.Police told 10News they have not been able to find anyone who heard gunshots or saw what might have happened. 792

SAN DIEGO (KGTV) — One person is dead after a shooting in the Mountain View area Wednesday.San Diego Police responded to reports of a shooting just before 3 p.m. in the 3500 block of Florence Lane. Officers arrived to find a victim in an alley suffering from a gunshot wound, according to City News Service.The victim, described only as a male, was pronounced dead at the scene.The suspected shooter was described as a man who appeared in his 30s, wearing shots and a black tank top. He seen fleeing the area with another person in a silver Dodge Ram pickup or similar truck, CNS reported.SDPD is investigating. The department advised people to avoid the area of 800 35th Street and 3400 Florence Street. 10News is monitoring this breaking news. 753