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The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The stars of country music, along with an assortment of stars from Hollywood, have converged on Nashville on Wednesday for the annual CMA Awards.  159

The Sanderson Sisters are hoping to put a spell on you, 27 years later.Actress Bette Midler was recently on Fox 5 New York's morning show "Good Day New York" where she confirmed that the original cast of "Hocus Pocus" was reuniting for a sequel.“They want to make a movie, they’ve asked us if we were interested and of course all of us said yes,” Midler said in the interview. “I’m game, I’m totally game.”The movie won’t be the first time the Sanderson Sisters would be reuniting. Midler, Sarah Jessica Parker, and Kathy Najimy are coming together, as their “Hocus Pocus” characters, for a special live, one-night-only virtual event, “In Search Of The Sanderson Sisters,” which is set for Friday. 705

The United States and North Korea have been holding secret, direct talks to prepare for a summit between President Donald Trump and North Korea leader Kim Jong Un, a sign that planning for the highly anticipated meeting is progressing, several administration officials familiar with the discussions tell CNN.Central Intelligence Agency Director Mike Pompeo and a team at the CIA have been working through intelligence back-channels to make preparations for the summit, the officials said. American and North Korean intelligence officials have spoken several times and have even met in a third country, with a focus on nailing down a location for the talks.Although the North Korean regime has not publicly declared its invitation by Kim Jong Un to meet with Trump, which was conveyed last month by a South Korean envoy, several officials say North Korea has since acknowledged Trump's acceptance, and Pyongyang has reaffirmed Kim is willing to discuss the denuclearization of the Korean peninsula. 1005

The Trump administration was moving ahead early Tuesday with the execution of the first federal prison inmate in 17 years after a divided Supreme Court reversed lower courts and ruled federal executions could proceed.Daniel Lewis Lee had been scheduled to receive a lethal dose of the powerful sedative pentobarbital at 4 p.m. EDT Monday. But a court order issued Monday morning by U.S. District Judge Tanya Chutkan prevented Lee’s execution.A federal appeals court in Washington refused the administration’s plea to step in, leaving the hold in place, before the Supreme Court acted by a 5-4 vote. Still, Lee’s lawyers insisted the execution could not go forward after midnight under federal regulations.With conservatives in the majority, the court said in an unsigned opinion that the prisoners’ “executions may proceed as planned.” The four liberal justices dissented.Lee’s execution was scheduled for about 4 a.m. EDT Tuesday, according to court papers.The Bureau of Prisons had continued with preparations even as lower courts paused the proceedings.Lee, of Yukon, Oklahoma, has had access to social visitors, visited with his spiritual adviser and has been allowed to receive mail, prison officials said. The witnesses for Lee are expected to include three family members, his lawyers and spiritual adviser.Lee was convicted in Arkansas of the 1996 killings of gun dealer William Mueller, his wife, Nancy, and her 8-year-old daughter, Sarah Powell.“The government has been trying to plow forward with these executions despite many unanswered questions about the legality of its new execution protocol,” said Shawn Nolan, one of the attorneys for the men facing federal execution.The decision to move forward during a global health pandemic that has killed more than 135,000 people in the United States and is ravaging prisons nationwide, drew scrutiny from civil rights groups as well as family of Lee’s victims.Some members of the victims’ family argued they would be put at high risk for the coronavirus if they had to travel to attend, and sought to delay the execution until it was safer to travel. Those claims were at first granted but also eventually overturned by the Supreme Court.Critics argue that the government is creating an unnecessary and manufactured urgency for political gain. The developments are also likely to add a new front to the national conversation about criminal justice reform in the lead-up to the 2020 elections.Two more executions are scheduled this week, though one, Wesley Ira Purkey, was on hold in a separate legal claim. Dustin Lee Honken’s execution was scheduled for on Friday.A fourth man, Keith Dwayne Nelson, is scheduled to be executed in August.In an interview with The Associated Press last week, Attorney General William Barr said the Justice Department has a duty to carry out the sentences imposed by the courts, including the death penalty, and to bring a sense of closure to the victims and those in the communities where the killings happened.But relatives of those killed by Lee strongly oppose that idea. They wanted to be present to counter any contention that it was being done on their behalf.“For us it is a matter of being there and saying, `This is not being done in our name; we do not want this,’” said relative Monica Veillette.The federal prison system has struggled in recent months to contain the exploding number of coronavirus cases behind bars. There are currently four confirmed coronavirus cases among inmates at the Terre Haute prison, according to federal statistics, and one inmate there has died.Barr said he believes the Bureau of Prisons could “carry out these executions without being at risk.” The agency has put a number of additional measures in place, including temperature checks and requiring witnesses to wear masks.But on Sunday, the Justice Department disclosed that a staff member involved in preparing for the execution had tested positive for the coronavirus, but said he had not been in the execution chamber and had not come into contact with anyone on the specialized team sent to handle the execution.The three men scheduled to be executed this week had also been given execution dates when Barr announced the federal government would resume executions last year, ending an informal moratorium on federal capital punishment as the issue receded from the public domain.Executions on the federal level have been rare and the government has put to death only three defendants since restoring the federal death penalty in 1988 — most recently in 2003, when Louis Jones was executed for the 1995 kidnapping, rape and murder of a young female soldier.In 2014, following a botched state execution in Oklahoma, President Barack Obama directed the Justice Department to conduct a broad review of capital punishment and issues surrounding lethal injection drugs.The attorney general said last July that the Obama-era review had been completed, clearing the way for executions to resume.___Associated Press writers Colleen Long and Mark Sherman in Washington, Michael Tarm in Chicago and Andrew DeMillo in Little Rock, Ark., contributed to this report. 5150