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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959
LOS ANGELES (AP) — Two young sisters missing from their Northern California home since Friday afternoon were found alive Sunday following a massive search that included helicopters and tracking dogs.Leia Carrico, 8, and Caroline Carrico, 5, were found "safe and sound" on Sunday morning by a fire captain and firefighter who had followed the girls' boot tracks, Humboldt County Sheriff William Honsal said."This is an absolute miracle," he said.Though the girls were dehydrated and cold, they were uninjured and "in good spirits," Honsal said.He said the girls were trained in outdoor survival through their local 4-H club and that authorities believed that helped them. They also were wearing boots and had eaten granola bars at some point while they were missing, he said."To have a positive outcome like this is just absolutely amazing," Honsal said.Using helicopters and tracking dogs, dozens of police and rescue personnel combed a vast and rugged rural area in the frantic search for the sisters.The girls had last been seen around 2:30 p.m. Friday outside their home in Benbow, a small community about 200 miles (320 kilometers) northwest of Sacramento.The searchers included National Guard members from Fresno and the U.S. Coast Guard, which provided one of its helicopters on top of a Black Hawk helicopter also being used.Rescuers were hopeful about finding the girls Saturday after they came across prints from the girls' rubber boots and wrappers from the granola bars, Lt. Mike Fridley said."The wrappers showed us a direction from where they started to where the wrappers ended up at," Fridley said.Fridley said he was the one who got to call the girls' mother and tell them her daughters were alive."She melted on the phone," he said.Honsal described the search area as vast, rugged and rural and the conditions as cold and sporadically rainy. 1866

Look up at the sky this week. We will get a treat as Jupiter and Saturn will be the closest they have been in the sky in four centuries. Appearing as a “Christmas star,” the "great conjunction" happens next Monday, December 21, which also happens to be the Winter Solstice, marking the start of the winter season. A conjunction happens when planets appear close in the night sky and line up with Earth’s orbits. The last time Jupiter and Saturn were this close was 1623, about 14 years after Galileo was using rudimentary telescopes to study outer space. However, that year, the conjunction was too close to the sun to view it. The last time Jupiter and Saturn were this close and visible to the Earth was during the Middle Ages in 1226. 746
LOS ANGELES (CNS) - A pair of active-duty U.S. Marines stationed at Camp Pendleton were arrested Tuesday morning on a federal grand jury indictment charging one of the Marines and three civilians with conspiring to distribute narcotics -- including oxycodone pills laced with fentanyl -- to civilians and members of the Marine Corps, one of whom suffered a fatal drug overdose in May.Lance Cpls. Anthony Ruben Whisenant, 20, and Ryan Douglas White, 22, were expected to make their initial appearances Tuesday afternoon in U.S. District Court in Los Angeles. Whisenant allegedly distributed narcotics to fellow Marines, including the one who overdosed, and White is charged with being an accessory after the fact for allegedly attempting to hinder the apprehension of Whisenant and an alleged drug supplier named in the indictment.The 14-count superseding indictment also charges:-- Jordan Nicholas McCormick, 26, of Palmdale, the lead defendant and the conspiracy's alleged supplier of LSD, ecstasy, cocaine and oxycodone pills laced with fentanyl to co-conspirators-- Gustavo Jaciel Solis, 24, of Sylmar, who allegedly distributed McCormick's drugs to civilians and military personnel-- Jessica Sarah Perez, 23, of Pacoima, who allegedly distributed narcotics, including fentanyl and cocaine, to civilian customersOn Aug. 11, Solis and Perez were indicted on fentanyl and cocaine distribution charges, and Solis was indicted on firearms-related charges. They have pleaded not guilty and their trial date is scheduled for Oct. 27. Solis is in federal custody and Perez is free on ,000 bond.Tuesday's updated indictment adds McCormick -- who is also in federal custody -- Whisenant and White as defendants, in addition to adding charges to the original indictment. According to the indictment, the conspiracy lasted from last November through this month and involved multiple sales of fentanyl- laced oxycodone to an undercover buyer, often for amounts exceeding ,000 per buy.On May 22, Solis sold 10 pills of oxycodone laced with fentanyl to an active-duty Marine who died of a drug overdose in the early morning hours of May 23, the indictment alleges.In addition to the conspiracy charge, McCormick, Solis, Whisenant and Perez face substantive charges of distribution of narcotics, including fentanyl. McCormick and Solis are also charged with possessing firearms in furtherance of drug crimes.If convicted, McCormick and Solis would face a sentence of 10 years to life in federal prison, and Whisenant and Perez would each face up to 20 years behind bars. White, if convicted, would face up to 10 years in federal prison. 2637
Live music might feel like a thing of the past, but venues and event organizers are working on ideas to bring it back sooner rather than later in the age of COVID-19.Ticketmaster says it has been working with event organizers and venues to navigate how they plan to admit fans to live sporting events and concerts once a vaccine is released.On Wednesday, Pfizer updated its vaccine efficacy, saying it is 95 percent effective and is seeking clearance soon. Earlier in the week, Moderna announced its vaccine also was 95 percent effective.Ticketmaster says it has discussed the idea of using a person’s vaccine status as a possible barometer of protection for admittance into events. In an email, the company said, “In short, we are not forcing anyone to do anything. Just exploring the ability to enhance our existing digital ticket capabilities to offer solutions for event organizers that could include testing and vaccine information with 3rd party health providers. Just a tool in the box for those that may want to use.”Here is how Ticketmaster says it might work: People who wanted to attend an event would upload their vaccine status through an app that connects to a third-party health care provider. That company would store the information and keep all other details private, abiding by HIPAA laws, according to Ticketmaster. That provider would then mark that person’s status so they could present their digital ticket along with their vaccine status at the event.Ticketmaster says this would not be mandatory, noting “Ticketmaster does not have the power to set policies around safety/entry requirements, which would include vaccines and/or testing protocols. That is up to the discretion of the event organizer. Ticketmaster continues to work with event organizers on all COVID safety measures and it will be up to each event organizer to set future requirements, based on their preferences and local health guidelines.” 1941
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