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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

BEIJING, Oct. 2 (Xinhua) -- Chinese archeologists have found evidence indicating that the mysterious ancient city of Loulan (Kroraina) once had highly-developed agricultural systems.Scientists from the Institute of Geology and Geophysics under the Chinese Academy of Sciences conducted remote sensing procedures, field investigations and sample testing in the area and found that there were once large tracts of farmlands in Loulan.The farmland featured regular and straight circumferences stretching for 200 to 1,000 meters as well as irrigation ditches running throughout, said Qin Xiaoguang, a member of the research team.Moreover, researchers found grain particles in the area's ground surface, which are very likely to be remains of crop plants, Qin said.These findings show that irrigation farming had been practiced in Loulan for at least 100 years, Qin said.Qin said they also found canal remains measuring 10 to 20 meters wide and 1.6 meters deep in the Loulan relics, indicating that the city, which is suspected of perishing in drought, was once rich in water resources.The ancient city was a pivotal stop along the famous Silk Road, but mysteriously disappeared around the third century AD.Previous historical records suggested that Loulan's economy was sustained by widespread agricultural activity, but no remains or other evidence had been found before the most recent discoveries.

BEIJING, Jan. 21 (Xinhua) -- Chinese leaders on Saturday offered festive greetings to people across the nation as well as overseas Chinese around the world at a gathering to mark the Lunar New Year that falls on Jan. 23.President Hu Jintao, top legislator Wu Bangguo, Premier Wen Jiabao and top political advisor Jia Qinglin attended the gathering, organized by the Central Committee of the Communist Party of China (CPC) and the State Council at the Great Hall of the People in Beijing.Hosting the gathering, Hu, also General Secretary of the CPC Central Committee, extended regards to Chinese people at home and abroad and foreign friends on behalf of the CPC Central Committee and the State Council, the Cabinet.Premier Wen delivered a speech at the gathering, saying that the country has made a good start to the Twelfth Five-Year Plan (2011-2015) at a time of an austere and complicated international economic situation.Wen said the government would maintain stable prices and steady, rapid economic development, accelerate the transformation of development patterns and adjust the economic structure in a bid to enhance sustainable development, as well as place more importance on people's livelihoods, letting the people share the achievements of reform."We are going to face bigger challenges in the new year," Wen said. "We have the will, determination, courage and ability to overcome any difficulties. We have confidence in the motherland's successful and bright future."Wen said the country will resolutely take the socialist road with Chinese characteristics, and promote economic growth and social progress, as well as improving people's livelihoods, and democracy, rule of law, equality and justice."We need to keep a clear head and thoroughly apply the scientific outlook on development, so to advance the reform and openning up policy and the socialist modernization construction.Wen called for excellent achievements in a bid to put the country on a firm footing for the upcoming 18th National Congress of the Communist Party of China.Other leaders, including Li Changchun, Xi Jinping, Li Keqiang, He Guoqiang and Zhou Yongkang, also attended the gathering.The Spring Festival, or the Chinese Lunar New Year, is the most important traditional festival for China.

SHENYANG, Nov. 17 (Xinhua) -- A MD-90 aircraft left the northeastern city of Shenyang for its American home on Thursday, ending the service of the last McDonnell-Douglas jet for Chinese airlines.Chinese carriers will no longer operate MD-made jets due to growing market demands, said Lu Changchun, deputy general manager with the north China branch of China Southern Airlines, which has operated the MD-90 jet for over a decade.MD-90 jets were involved in no accidents during the decade-long-service in China, so safety concerns did not lead to their retirement, Lu said, adding about 1,000 MD-90 jets are still flying around the world.Lu, however, admitted that supply of aircraft materials was affected as the production line of MD jets shrank, after McDonnell-Douglas Cooperation was merged into Boeing in 1997.MD jets were replaced mainly because Chinese airlines need new models to accommodate air travel demands fueled by the economic boom, Lu said.The north China branch of China Southern Airlines also announced Thursday the retirement of five A300-600R planes, which are replaced by A320 family jets. China Southern Airlines began flying an Airbus A380 superjumbo in China in October.China's domestic air travel market is predicted to grow 13.9 percent annually by 2014 and transport 379 million domestic air passengers, which will make the country the world's second-largest air travel market after the United States, according to a report released by the International Air Transport Association.Back in the 1990s, a Shanghai-based aircraft maker assembled two MD-90 jets in China, Lu said, adding the two jets retired this year.Change of jets model serves the strategic transformation of China Southern Airlines and meets the market demands, Lu said.Li Jiaxiang, chief of China's civil aviation administration, estimated that over 1.5 trillion yuan (235 billion U.S. dollars) will be invested in the civil aviation industry by 2015, adding about 2,000 aircraft to the country's fleet.Commercial Aircraft Corporation of China, producer of China's first self-developed jumbo jet, the C919, has announced that it will complete the design for the passenger plane in 2012. The jet is expected to take off in 2014 and put into service in 2016.

BEIJING, Oct. 11 (Xinhuanet) -- Scientists have discovered that blind optimism is related to brain's frontal lobes which are associated with processing errors, according to a British study published Monday in the journal Nature Neuroscience.Scientists at the University College of London scanned brains of volunteers who were asked to estimate their personal likelihood of involving in negative events, like a divorce or cancer,  before and after given the average probability of these events occurring.They found that the volunteers who estimated lower probability (or the more optimistic ones) than the given one raised their estimates a little bit later while those estimated higher probability altered their estimates much more.Through the brain scanner, scientists saw there was less activity in the volunteers' frontal regions when the information given was worse than expected while more activity when the information was better than expected. It suggested that the more optimistic people neglected the negative predictions."The more optimistic we are, the less likely we are to be influenced by negative information about the future," said Dr. Tali Sharot, lead author of the study. He added being optimistic clearly had some benefits, "but it can also mean that we are less likely to take precautionary action, such as practising safe sex or saving for retirement. So why don't we learn from cautionary information?"

来源：资阳报