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WASHINGTON, Aug. 4 (Xinhua) -- Researchers have found a way to turn mouse embryonic stem cells into sperm and this finding opens up new avenues for infertility research and treatment, according to a study published Thursday in the online edition of journal Cell,A Kyoto University team coaxed mouse embryonic stem cells into sperm precursors, called primordial germ cells (PGCs), and shown that these cells can give rise to healthy sperm. The researchers say that such in vitro reconstitution of germ cell development represents one of the most fundamental challenges in biology.When transplanted into mice that were unable to produce sperm normally, the stem cell derived PGCs produced normal-looking sperm, which were then used to successfully fertilize eggs. These fertilized eggs, when transplanted into a recipient mother, produced healthy offspring that grew into fertile male and female adult mice. The same procedure could produce fertile offspring from induced pluripotent stem cells that are often derived from adult skin cells."Continued investigations aimed at in vitro reconstitution of germ cell development, including the induction of female primordial germ cell-like cells and their descendants, will be crucial for a more comprehensive understanding of germ cell biology in general, as well as for the advancement of reproductive technology and medicine," the researchers wrote.
SYDNEY, July 15 (Xinhua) -- The world's first drug to increase life expectancy of people with advanced melanoma has been approved for use in Australia, local media reported on Friday.The breakthrough drug Yervoy got approval from the Therapeutics Good Association (TGA) on Friday amid hopes it could add two years to the life of people with the most lethal form of skin cancer but for whom other treatments have failed, the Australian Associated Press (AAP) said.Clearance for the drug's use in Australia follows similar approvals by the U.S. health regulator in March.Yervoy works by attacking and destroying cancer cells.Patients are hooked up to an intravenous drip once every three weeks for a total of four doses.Professor Peter Hersey, consultant immunologist to the Melanoma Institute Australia, said no other drug had improved survival rates like Yervoy."Not all patients respond to it but those who do have a good chance of living longer than they would have otherwise," Hersey told AAP.While it may improve survival rates, Yervoy can produce side effects from diarrhea and vomiting to serious blood infections and kidney failure.The average survival time for people with advanced melanoma is just six months.A global study of 676 people with melanoma found that 45 percent of patients given Yervoy were still alive after one year, according to AAP.More than 20 percent lived at least two years, with a small number managing to survive for six years.A separate study, published in June, which showed similarly improved survival rates for patients with newly diagnosed advanced melanoma, has raised hopes that Yervoy could be made more widely available.Melanoma is the fourth most common cancer in Australia, with 10, 300 people diagnosed each year.

COPENHAGEN, June 7 (Xinhua) -- The outbreak of infections caused by E. coli bacteria may be over in Denmark as no new cases have been reported here since Friday.According to Denmark's National Serum Institute (NSI), there are 18 confirmed cases of severe intestinal infection caused by exposure to the bacteria as of Monday. No new infections have been reported since Friday, it added.The confirmed cases are said to consist of 10 men and 8 women aged between 23 and 81 years of age. Seven show symptoms of kidney failure which is associated with advanced stages of the infection.All but one are believed to have contracted the infection while traveling in northern Germany, where the outbreak started, the NSI said.So far, the E. coli infection has claimed 21 lives in Germany, which reports over 2,100 confirmed and suspected cases. It has also spread to 12 countries according to the World Health Organization (WHO)."This particular strain of E.coli has been identified in some people sporadically in the past, but it has not been known to have been associated with outbreaks in the past," a WHO spokesperson said Friday, adding it was a "very, very rare strain."Health authorities in Germany now suspect bean sprouts as the source of contamination in this outbreak, although this is yet to be confirmed.Dr Kaare Moelbak, an epidemiologist at NSI told Danish media Sunday that bean sprouts were a "very likely" source of contamination.Cucumbers were initially suspected and Denmark's food authority continues to warn against eating raw tomato, cucumber or lettuce from Germany until the source is established.Children are normally most vulnerable to E. coli infection but most of those infected in this outbreak are above the age of 20 years, Moelbak told Xinhua last week.He said children are likely less affected by this outbreak as they usually eat fewer salads than adults.In Germany, it is mostly women who have been affected by the infection. Moelbak explained the skew in infections saying women tend to choose to eat more vegetables than men, in comments made to Danish media Thursday.
JIANGYIN, Jiangsu, July 1 (Xinhua) -- China's manned deep-diving submersible, the Jiaolong, embarked on a journey on Friday during which it will make a 5,000-meter dive in the Pacific Ocean.During the dive, the submersible will undergo several operational tests in which it will take photos, shoot video, survey seabeds and take samples from the ocean floor, according to Jin Jiancai, deputy director of the submersible's diving test program team.The tests will be conducted in the Pacific Ocean in accordance with a contract signed between the China Ocean Mineral Resources Research & Development Association and the International Seabed Authority (ISA).The submersible is scheduled to spend 47 days at sea, according to a statement from the Ministry of Science and Technology.A submersible differs from a submarine, as it typically depends on another vessel or facility for support.The Jiaolong, designed to reach a depth of 7,000 meters, completed 17 dives in the South China Sea between May 31 and July 18 last year, reaching 3,759 meters during its deepest dive.In the year since the submersible's last dive, program team members have made several technical improvements to the submersible and its support vessel, Jin said.Jin said the program team members are "very confident" about the test.He also stressed that the test will be carried out in accordance with the provisions of the United Nations Convention on the Law of the Sea as well as the ISA's rules and regulations.The Jiaolong is the world's first manned submersible designed to reach depths of 7,000 meters below sea level, according to Xu Qinan, the submersible's chief designer.
XICHANG, Sichuan, June 21 (Xinhua) -- China successfully launched a new communication satellite, the Zhongxing-10, from its Xichang Satellite Launch Center in southwest Sichuan Province on early Tuesday.The satellite, carried by a Long March-3B rocket carrier, blasted off from the center at 0:13 a.m., said a statement from the center.According to statistics from the control center, the satellite successfully separated from its carrier rocket and entered Earth's orbit as scheduled, 26 minutes after being launched.The Zhongxing-10 was designed and manufactured by the China Academy of Space Technology under the China Aerospace Science and Technology Corporation.The satellite will provide communication, broadcasting and data transmission services for users in China and the Asia-Pacific region. It will replace the Zhongxing-5B satellite, which was launched in 1998.The launch was the 138th mission for the Long March carrier rocket series.
来源:资阳报