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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The Tuesday after Thanksgiving may be known as Travel Deal Tuesday, a day offering deals on airfare. But Cyber Monday is the day to book your dream vacation.  If you’re looking to take a family vacation, you may want to look at Universal Studios and Universal Island Treasure in Orlando.On undercovertourist.com, you can get two-day park tickets, plus two extra days free, if you buy today. That’s a total of 3 for four people for four full days. If you want another option for warm weather, you could travel to Miami and take an all-inclusive three-day Royal Caribbean cruise to the Bahamas. If you buy one full-price ticket, you’ll get your second one 60 percent off. The third and fourth ticket will be 30 percent off!The total cost for a family of four will cost 5. The deal can be found on americandiscountcruises.com.Have you always wanted to go to the Grand Canyon? If you take the Grand Canyon train tour, you can save 50 percent on your once in a lifetime trip.Thetrain.com is offering a three-day, two-night stay in Williams, Arizona for 5 for two people. That's a 0 savings.If the west coast is more your style, a family of four can head to LEGO Land for a crazy good deal. LEGO is offering 30 percent off rooms and 50 off two-day LEGO Land tickets on their website. You can get all of that for 1 per person for a two-day stay. 1381

The world is in the midst of a pandemic. While it's important to stay informed, and up-to-date on the latest COVID-19-related news, it's also OK to take mental breaks.Video games are among the best forms of entertainment to help provide an escape. Here are nine titles to help ease your stress.Animal Crossing: New Horizons(Nintendo Switch) KGUN's review 362

The votes are in and the people have spoken.The annual People's Choice Awards, which honor popular film, TV, music, podcasts and more, took place Sunday night.Check out the full list of winners below to see if your favorite won.Movie of 2018 249

The romance between "Sweetener" singer Ariana Grande and "SNL" performer Pete Davidson has turned sour.The couple, whose whirlwind romance-turned-engagement powered the celebrity gossip machine through the summer, has split, a source close to the singer tells CNN.Davidson confirmed their engagement in June. They had been dating a few weeks at the time. 362

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