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Johnson & Johnson is beginning a huge final-stage study to try to prove if a single-dose COVID-19 vaccine can protect against the virus. It will be one of the world’s largest coronavirus vaccine studies so far, testing in 60,000 volunteers in the U.S., South Africa, Argentina, Brazil, Chile, Colombia, Mexico and Peru. A handful of other vaccines in the U.S. and elsewhere are already in final testing. The two other vaccine candidates in final-phase testing in the U.S. — candidates made by Moderna and Pfizer — were both approved in July. Earlier this month, Dr. Anthony Fauci said those trials should be filled by the end of September, meaning they should be completed by late November or early December.Hopes are high that answers about at least one could come by year’s end, maybe sooner. U.S. health officials insist the race for a vaccine isn’t cutting corners, despite enormous political pressure. 918
LA JOLLA (KGTV): Researchers at the UC San Diego Moores Cancer Center and the La Jolla Institute of Allergy and Immunology have teamed up to find a new way to fight cancer.They've created a vaccine that can help teach the immune system how to attack only cancer cells and leave the rest of the body alone."Patients will be able to tolerate their therapy much better than they have so far on conventional approaches," says Dr. Stephen Schoenberger from the La Jolla Institute.Each vaccine is highly personalized to the patient. According to a release from UC San Diego, the vaccines "defines the neoantigens – foreign protein fragments recognized by the immune system – in a patient’s cancer. With neoantigens identified, the team can identify peptides – strings of amino acids – that can be used to create a vaccine to stimulate a protective immune system response."Simply put, the new vaccine takes information from a patient's immune system and the tumor and uses it to help white blood cells to fight it."We're giving them life and giving them hope," says Dr. Schoenberger.The first patient in the clinical trial is Tamara Strauss. She was diagnosed with pancreatic cancer in 2015 and went through chemotherapy and surgery."It was brutal," says Strauss. "It's been three and a half years of hell."Strauss' parents helped fund the clinical trial with a million donation. She says she feels fortunate they could do that, but also hopeful that it helps others down the road."I really pray that this vaccine and personalized form of treatment really does change the paradigm of cancer treatment," says Strauss.During the trial, ten patients will get three doses of the vaccine. They'll also be on Keytruda, an immune system boosting drug for up to two years. Their health will be monitored for five years to determine the vaccine's effectiveness. 1871
Jon Lester is now a free agent in the MLB, after a million option was declined by the Chicago Cubs. If he does leave the team, he left fans a huge parting gift: ,000 in beer.On Friday, before the official word the team declined Lester’s option, the pitcher tweeted he wanted to thank his fans.“Regardless of what’s next I want to thank the fans for the past 6 years. So this weekend (10.30-11.1) Im (sic) buying y’all my favorite beer,” Lester tweeted, then added four bars in the Chicago area. “Your 1st @MillerLite is on me. Just tell em to put it on #JonsTab,” Lester continued. 596
Just signed an exclusive agreement at the Pentagon with Acting Secretary of the @USNavy to redevelop its NAVWAR facility — and create with it a transit hub that finally connects the trolley to @SanDiegoAirport! Huge milestone w/ @SANDAG built on San Diego’s proud Naval heritage pic.twitter.com/BS14PYFPHg— Kevin Faulconer (@Kevin_Faulconer) January 23, 2020 372
LA JOLLA, Calif. (KGTV) — City crews have started emergency repairs to an unstable cave located underneath a busy La Jolla street.Coast Blvd. was closed late Thursday after experts found weaknesses in Cook's Crack, a sea cave underneath Coast Blvd. near Cave St."We're starting to see above ... the looser, weaker material. That's a trigger right off the bat that, 'Oh my God, we don't have the beefy rock bridging across anymore. So that's what got out attention," said James Nagelvoort, city public works director.RELATED: La Jolla streets closed for emergency stabilization of Cook's Crack caveThe discovery came as crews prepared to repair Coast Blvd. Assessors discovered that if too much weight is above the cave or heavy seismic vibrations hit the area, the road could collapse, according to the city.A crew from Texas was called to lead the project, driving overnight to La Jolla Friday.Crews plan to first fill the cave's cracks with an eco-friendly polyurethane mix to strengthen the dirt. The next phase will be to clear out all of the water and fill the cave with a concrete mix.Construction is expected to last about six weeks, closing parts of Coast Blvd. and Cave St.Cook's Crack is located in the area between La Jolla Cove and the popular Cave Store. The strip of road leads down to seaside restaurants and parking for many tourists and residents.The project required the city to quickly close the road before locals realized what the issue was, though businesses and residents were allowed to pass through the area Friday."They said there's been some shift in the road itself," David Heine, owner of nearby Brockton Villa Restaurant, told 10News. "The busiest two weeks of summer, literally ... Obviously safety's the number one concern for any city, and we respect that." 1799
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