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Authorities asked for the public's help Wednesday in identifying a woman who allegedly broke into an Irvine home and went into a resident's bedroom before being chased out by a resident.Surveillance video captured the woman ringing the doorbell of a residence on Jan. 18 at 8:34 p.m., Irvine, California police said.The homeowner — who did not want her name made public — said when nobody came to the door, the intruder made her way into the house via a side door and then into the upstairs bedroom where the homeowner's college-age daughter was sleeping.The daughter woke up and asked the intruder who she was, the family said. The trespasser managed to flee after the daughter chased her out of the house, according to the mother.After reviewing surveillance footage, the family said they discovered that the intruder had also come to the home in December. It's unclear whether she was able to enter the house at that time.The family said they did not know the woman, who was described by police as Asian with brown hair, brown eyes and of average height. The family has changed the locks on their home.Anyone with information can call Irvine Police Department Detective Matt Ricci at 949-724-7189 or email mricci@cityofirvine.org. 1261

AstraZeneca is the latest drugmaker to announce promising Phase 3 trial results from its COVID-19 vaccine candidate.On Monday, AstraZeneca said its two-shot vaccine candidate has been 90% effective thus far along with no safety concerns.“These findings show that we have an effective vaccine that will save many lives," said Professor Andrew Pollard, the chief executive of the study. Excitingly, we’ve found that one of our dosing regimens may be around 90% effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. Today’s announcement is only possible thanks to the many volunteers in our trial, and the hard working and talented team of researchers based around the world.”The company added in its press release that its vaccine candidate offers two distinct advantages over vaccines made by Pfizer and Moderna — it's cheaper to produce, and does not need to be stored in ultra-cold conditions before use.AstraZeneca added that the company would "immediately" prepare regulatory paperwork to seek Emergency Use Listing status from the World Health Organization.AstraZeneca is just the latest drug company to report encouraging results from its COVID-19 vaccine candidate.Last week, Pfizer said it had submitted Emergency Use Authorization paperwork to the Food & Drug Administration (FDA) after a final analysis of its vaccine candidate proved to be 95% effective in preventing COVID-19. The FDA is expected to approve the drug in the coming weeks.Moderna has also said that early results show its vaccine candidate to be 95% effective, and is on track to have the drug approved for Emergency Use Authorization by the end of the year.AstraZeneca, Pfizer and Moderna are all shattering records for vaccine development. The three vaccines are all on track to be approved for widespread use in uder a year. Typically, it takes several years for a vaccine to go from development to approval.The announcement comes as COVID-19 is spreading around the world at a rate not previously seen since the pandemic began. And while all three companies are pre-producing their vaccines in the hope that it will be approved, health experts warn that they won't be widely available until spring 2021. 2247

ATLANTA (AP) — A federal judge is permanently blocking Georgia’s 2019 “heartbeat" abortion law, finding that it violates the U.S. Constitution.U.S. District Judge Steve Jones ruled against the state Monday in a lawsuit filed by abortion providers and an advocacy group.Jones had temporarily blocked the law in October, and it never went into effect.The new ruling permanently enjoins the state from ever enforcing House Bill 481.The measure sought to ban abortions once a “detectable human heartbeat” was present, with some limited exceptions.Cardiac activity can be detected by ultrasound as early as six weeks into a pregnancy.Jones found the law violated the 14th Amendment. 685

Astrophysicist and author Neil deGrasse Tyson has denied allegations of sexual misconduct made against him by three women.Last month, three women told Patheos, a religion and spirituality website, that Tyson harassed them and made inappropriate sexual advances as early as 1984 and in recent years."Accusations can damage a reputation and a marriage. Sometimes irreversibly. I see myself as loving husband and as a public servant -- a scientist and educator who serves at the will of the public. I am grateful for the support I've received from those who continue to respect and value me and my work," he wrote in a lengthy Facebook post titled "On Being Accused."Tyson disputed or offered a different version of the allegations against him.Katelyn N. Allers, an associate professor of physics and astronomy at Bucknell University in Pennsylvania, told Patheos that Tyson grabbed her arm and reached into her dress while looking at her tattoo of the solar system. She said the incident happened during a party after a gathering of the American Astronomical Society in 2009. 1081

Astronaut Nick Hague was ready for a mission that would send him and cosmonaut Aleksey Ovchinin to the International Space Station to join a crew of three that was already on board the station. But just minutes into last week's flight on board the Soyuz MS-10 craft, the crew needed to abort the mission due to a booster failure. The incident marked the first aborted flight of a Soyuz craft in more than four decades. On Wednesday, Hague described the harrowing moments that followed after the booster's failure. “We were tossed back and forth inside the capsule a little bit and thrusted away from the rocket as soon as the launch abort system had recognized there was a problem with the booster," Hague said. That is when Hague's training and past as a US Air Force pilot kicked in. “My career in the Air Force has done a lot to help me prepare for stressful situations like this, whether it’s through deployments or my time in flight test where we have had to deal with failures in aircraft that you’re in and having to get down on the ground immediately,” he said. “We train endlessly to address those types of situations."After surviving an incident at 30 miles above the ground, Hague plans on making another attempt to visit the International Space Station in 2019.   1338

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