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First came a high fever, drenching sweats and muscle aches. Then, almost a month later, a weird numbness that spread down the right side of her body.Darlene Gildersleeve thought she had recovered from COVID-19. Doctors said she just needed rest. And for several days, no one suspected her worsening symptoms were related — until a May 4 video call, when her physician heard her slurred speech and consulted a specialist.“You’ve had two strokes,” a neurologist told her at the hospital. The Hopkinton, New Hampshire, mother of three is only 43.Blood clots that can cause strokes, heart attacks and dangerous blockages in the legs and lungs are increasingly being found in COVID-19 patients, including some children. Even tiny clots that can damage tissue throughout the body have been seen in hospitalized patients and in autopsies, confounding doctors’ understanding of what was once considered mainly a respiratory infection.“I have to be humble and say I don’t know what’s going on there, but boy we need to find that out because unless you know what the pathogenic (disease-causing) mechanism is, it’s going to be tough to do intervention,” Dr. Anthony Fauci, the nation’s top infectious disease expert, remarked during a medical journal interview last month.Doctors and scientists at dozens of hospitals and universities around the globe are seeking answers while trying to measure virus patients’ risks for clots and testing drugs to treat or prevent them.Gildersleeve said health authorities “need to put out an urgent warning about strokes” and coronavirus. Not knowing the possible link “made me doubt myself” when symptoms appeared, she said.Some conditions that make some COVID-19 patients vulnerable to severe complications, including obesity and diabetes, can increase clot risks. But many authorities believe how the virus attacks and the way the body responds both play a role.“COVID-19 is the most thrombotic (clot-producing) disease we’ve ever seen in our lifetime,” said Dr. Alex Spyropoulos, a clot specialist and professor at Feinstein Institutes for Medical Research in Manhasset, New York.Clotting has been seen in other coronavirus infections, including SARS, but on a much smaller scale, he said.Scientists believe the coronavirus enters the body through enzyme-receptors found throughout the body, including in cells lining the inside of blood vessels. Some theorize that it may promote clotting by somehow injuring those vessels as it spreads. That injury may cause a severe immune response as the body tries to fight the infection, resulting in inflammation that may also damage vessels and promote clotting, said Dr. Valentin Fuster, director of Mount Sinai Heart hospital in New York.It’s unclear how many COVID-19 patients develop clots. Studies from China, Europe and the United States suggest rates ranging from 3% to 70% of hospitalized COVID-19 patients; more rigorous research is needed to determine the true prevalence, the National Institutes of Health says.Prevalence in patients with mild disease is unknown and the agency says there isn’t enough evidence to recommend routine clot screening for all virus patients without clotting symptoms, which may include swelling, pain or reddish discoloring in an arm or leg.Some hospitals have found 40% of deaths in COVID-19 patients are from blood clots. Spyropoulos said that’s been true at his 23-hospital system in the New York City area, Northwell Health, which has treated over 11,000 COVID-19 patients.Cases there have dropped by almost half in the past month, allowing more time for research before an expected second and maybe third wave of infections, he said, adding: “We’re racing against time to answer the key clinical questions.”Patients hospitalized with any severe illness face increased risks for clots, partly from being bedridden and inactive. They commonly receive blood-thinning drugs for prevention. Some doctors are trying higher-than-usual doses for prevention in hospitalized coronavirus patients.A few have used powerful clot-busting medicines typically used to treat strokes, with mixed results. In guidance issued May 12, the NIH said more research is needed to show whether that approach has any benefits.Fuster was involved in preliminary research on nearly 2,800 COVID-19 patients at five hospitals in the Mount Sinai system. A look at their outcomes suggests slightly better survival chances for virus patients on ventilators who received blood thinners than among those who didn’t. Although the results are not conclusive, all COVID-19 patients at Mount Sinai receive blood thinners for clot prevention unless they are at risk for bleeding, a potential side effect, Fuster said.Some COVID-19 patients, like Gildersleeve, develop dangerous clots when their infections seem to have subsided, Spyropoulos said. Patients treated at Northwell for severe disease are sent home with a once-a-day blood thinner and a soon to be published study will detail their experiences. Spyropoulos has been a paid consultant to Janssen Pharmaceuticals, makers of Xarelto, the drug’s brand name.In addition, Northwell is taking part in a multi-center study that will test using blood thinners for clot prevention in COVID-19 patients not sick enough to require hospitalization.In a small study published May 15, University of Colorado doctors found that combined scores on two tests measuring clotting markers in the blood can help determine which patients will develop large dangerous clots. One test measures a protein fragment called D-dimer, a remnant of dissolved clots. High levels sometimes indicate dangerous clots that form deep in leg veins and travel to the lungs or other organs.Dr. Behnood Bikdeli of Columbia University’s Irving Medical Center, said D-dimer levels in many of his COVID-19 patients have been alarmingly high, as much as 50 times higher than normal.Concerns about blood clots in COVID-19 patients prompted a recent 30-page consensus statement from an international group of physicians and researchers. Bikdeli is the lead author.It says that testing to find clots that require treatment includes X-rays or ultrasound exams, but poses a risk for health care workers because the virus is so contagious. Bikdeli said he fears when protective gear was more scarce, some dangerous clots were undiagnosed and untreated.Social distancing may make people more sedentary and more vulnerable to clots, particularly older adults, so doctors should encourage activity or exercises that can be done in the home as a preventive measure, the statement says.Warnell Vega got that advice after collapsing at home April 19 from a large clot blocking a lung artery. Doctors at Mount Sinai Morningside think it was coronavirus-related. Vega, 33, a lunch maker for New York City school children, spent a week in intensive care on oxygen and blood thinners, which he’s been told to continue taking for three months.“I just have to watch out for any bleeding, and have to be careful not to cut myself,” Vega said.Gildersleeve, the New Hampshire stroke patient, was also sent home with a blood thinner. She gets physical therapy to improve strength and balance. She still has some numbness and vision problems that mean driving is out, for now.Doctors are unable to predict when or whether she’ll regain all her abilities.”I’m trying to remain positive about recovering,” she said. ’’I just have to be patient and listen to my body and not push too hard.”___Follow AP Medical Writer Lindsey Tanner at @LindseyTanner.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’ 7639

HAMPTON, Va. - Hampton University's Mo'ne Davis took the country by storm in 2014, becoming the first girl to pitch a shutout in Little League World Series history. That performance led to another historic moment when Davis became the first Litte Leaguer to be featured on the cover of Sports Illustrated. Due to the stardom Davis experienced after making headlines as a 13-year-old, there was a lot of excitement when she decided to play softball at Hampton. “I was like oh snap," Hampton outfielder/first baseman Brianna Anderson said. "I was like oh this is big.” “When everyone found out she was coming it was kind of a cool deal, you know,” Hampton head softball coach Angela Nicholson said.Although, the position that earned her fame more than five years ago is now in the past for Davis.In fact, she won't even pitch to her teammates during practice, even though they ask to hit off her "like every day," Nicholson said.As a 13-year-old baseball player, Davis was pitching as fast as 70 miles per hour, but now she utilizes that arm strength at middle infield.“I wanted to keep hitting so I was like I'm just gonna play an field position," Davis said. “Her transition and her glove work is phenomenal, and that’s where you see the baseball side of things,” Nicholson said.The transition, early on, was accompanied with some uncertainty by the Pirates. The team was unsure what to expect from someone who experienced stardom at such a young age.“I thought the kid was gonna be arrogant or cocky, but it was complete opposite," Nicholson said. "If you didn’t know who she was it would never come out. She doesn’t speak of it. She just wants to be a normal everyday person.” “From the moment she stepped on campus she’s worked harder than everybody," Hampton pitcher Emily Workman said. "She just always gives it 110 percent.” Davis made her Pirates debut on Sunday, going 1-for-3 with a two-run single in Hampton's season opener against North Carolina A&T. The Pirates take the field again on Friday in Greenville, North Carolina, where they'll face George Washington University.This article was written by Megan Plain for 2145

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Going to college can be life changing. For many students, that means studying something they enjoy, getting a degree in that subject and then chasing the American dream. But for others, pursuing a higher education can turn into a nightmare “I just felt so bad for my parents,” said college student Annalise Hoerter. “I was like, ‘they just spent so much money on me and now I have to get it back.” Hoerter attended the now defunct The Art Institute of Colorado for three-and-a-half years studying photography. With just six months shy of graduating, the school lost its accreditation and closed – costing Hoerter big bucks and causing her a whole lot of headaches “Right now, I’m in the hole for ,000,” she said. “That was definitely a dark cloud over the school.” Stories like Hoerter’s popped up across the country as several for-profit schools either lost their accreditation or shut down completely In 2016, one of the largest for-profit schools on the country, ITT Technical Institute, shut its door for good – sending some of its students into a frenzy and leaving them with massive debt. “At first, we were able to provide outreach and personalized guidance to help students to see how they might be able to transition from a for-profit college to a state institution,” said Richard Curtis of Cincinnati State Technical and Community College. The public college was one of several schools to reach out to former ITT Tech students and help them continue their education. “Our program chairs and our faculty, they worked directly with the students to help them evaluate their background so that they could get onto a new pathway,” he said. Though schools like Cincinnati State helped some students get back into school, many were still left with debt and nowhere to go. Rules for debt relief have changed with the presidential administrations. That's where organizations like the National Association of Student Financial Aid Administrators step in. NASFAA says it's helped more than 6,000 students at 30 closed institutions across the country apply to the department of education to get their student loans canceled.“There’s a lot of things that goes through a student’s mind when they’re informed that their school is closing down,” said Thad Spaulding, interim associate vice president of enrollment management at Metropolitan State University of Denver. Spaulding says prospective students need to do their homework before committing to any school – public or for-profit. “It’s warranted for students to do a little bit of time researching that they want to attend whether it be through studentaid.gov,” he said. Though Hoerter still carries tens of thousands of dollars of student debt, she was able to transfer to MSU Denver where she’s six months away from graduating and has accepted a job as a school photographer. For now, she says she’s working with a loan company in hopes of cutting down her Art Institute debt. “Which in the end is fantastic,” she said. “But it’s still ,000 of a degree that I’m never going to get.” 3056