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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462
SURPRISE, Ariz. — LaRissa Waln's been waiting for the day she'd get to walk across the stage and receive her high school diploma, but she might not get the chance. The 17-year-old attends Valley Vista High School in Surprise, Arizona, and says she started decorating her cap for the ceremony more than a week ago. But just this week, school administrators said caps had to remain blank. "If I do wear it, I won't be able to walk," Waln said. Her cap though has a special meaning. Waln's father helped create the design, a tribute to their Native American culture. The cap is adorned with intricate beadwork that represents the Wahpeton Sioux tribe. "It means everything to me, to be a part of it in any way possible," she added. "We did pay for the cap and gown out of our own pockets, and we should have the right to decorate it." Administrators said it wasn't a school policy though; it's enforced district-wide. Here's Dysart Unified School District's full statement: “The Dysart Unified School District understands that graduation is an exciting time for students, and our goal is to ensure each student is appropriately recognized for successfully graduating high school. We respect the formality of our graduations and believe that decorated caps take away from the purpose of the ceremony, calling unnecessary attention to individual students. Only school-approved regalia, which is typically academic in nature, are allowed to adorn the gown. We appreciate the desire of students to honor cultural traditions, and there are many ways to do so beyond decorating a graduation cap.”Waln says she and her father have tried meeting with administrators about the issue, even asking for a written copy of the policy, but say neither the school nor the district has provided one. She also found no policies on graduation caps in the school's handbook. "I worked four years for this," Waln said. "I'll always stick with my culture no matter what. If it means I can't walk at graduation, then I guess I won't walk. But I will be there." 2046

Sen. Ted Cruz, R-Texas, announced on Sunday that he is self-quarantining himself after learning that he had interacted with someone who tested positive with COVID-19 at last week's CPAC Conference. The conference was attended by top Republican officials, including President Donald Trump and Vice President Mike Pence. Cruz confirmed in a statement on Sunday that he briefly interacted with the patient, and that he shook hands with the person. Health experts said that the public should avoid direct contact with those carrying the virus, no matter if they're showing symptoms. Cruz said in a statement that he has not come down with any COVID-19 symptoms, and has been in contract with a number of officials, including Pence and newly-announced White House Chief of Staff Mark Meadows. He added that he is self-quarantining as a precaution as his brief interaction does not meet the federal standard for self-quarantine.Cruz issued the following statement on Sunday:"Last night, I was informed that 10 days ago at CPAC I briefly interacted with an individual who is currently symptomatic and has tested positive for COVID-19. That interaction consisted of a brief conversation and a handshake."I have consulted with medical authorities from the Houston Health Department, the Harris County Public Health Department, the Centers for Disease Control and Prevention, and the Department of Health and Human Services, as well as my personal physician. I have also spoken with Vice President Pence, Leader McConnell, and Mark Meadows."I'm not experiencing any symptoms, and I feel fine and healthy. Given that the interaction was 10 days ago, that the average incubation period is 5-6 days, that the interaction was for less than a minute, and that I have no current symptoms, the medical authorities have advised me that the odds of transmission from the other individual to me were extremely low."The physicians further advised that testing is not effective before symptoms manifest, and my brief interaction with the individual does not meet the CDC criteria for self-quarantine."The medical authorities explicitly advised me that, given the above criteria, the people who have interacted with me in the 10 days since CPAC should not be concerned about potential transmission."Nevertheless, out of an abundance of caution, and because of how frequently I interact with my constituents as a part of my job and to give everyone peace of mind, I have decided to remain at my home in Texas this week, until a full 14 days have passed since the CPAC interaction."Everyone should continue to treat this outbreak seriously and be driven by facts and medical science. We need to continue to be proactive in mobilizing resources to combat this outbreak-including the .3 billion in emergency funding we provided last week-and I encourage everyone to follow the recommendations of the CDC and other health professionals in protecting their own health and welfare, as well as the health and welfare of those around them." 3022
Short-video social media app TikTok is known for videos of dancing, singing and jokes. The app’s popularity has skyrocketed this year, especially with kids and teens."It’s mostly younger kids,” Kendall Wheeler explained. Wheeler, who has been dancing since she was 3 years old, has more than 440,000 followers on the app. The 17-year-old dancer downloaded the app when she was 15 as a way to share dance — and other — videos. Now, her content has expanded to acting, trends and other topics, and her image is attracting companies looking to sponsor or advertise their products with her.“A lot more companies have been reaching out to me,” she said. “I’ve made a pretty good amount of money from just going live.”Going live on the app and interacting with followers is the easiest way to make money on TikTok, and it allows for direct audience engagement. “My friends are pretty much from TikTok and I FaceTime them all the time,” she explained. “My social circle is on TikTok.”A 991
Sixty days of bed rest is the order for folks chosen to participate in a study being conducted by NASA and ESA on Earth.Participants from the United States will need a passport, as this study is happening in Germany."The German Aerospace Center (DLR) is researching how the body changes in weightlessness," says the study sign-up page online. "Bed rest simulates this condition. We are looking for test persons who take part in a bed rest study from September to December 2019 in Cologne and spend 60 days lying down. "Based on the study results, scientists are developing countermeasures that reduce the negative effects of weightlessness on astronauts," the website says.The study is called "AGBRESA" (Artificial Gravity Bed Rest Study) and the information that comes from it is used to improve conditions for astronauts in space."We accompany you on your mission as a terrestrial astronaut. Our team consists of scientific, physiotherapeutic and medical professionals - and nutritionists are also on board to take care of your physical well-being," says the website. 1081
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