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WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."

SHENYANG, Aug. 16 (Xinhua) -- Two more cutaneous anthrax infections were reported in northeast Liaoning Province, bringing the total number of people who were hospitalized for the disease to 32, health authorities said Tuesday.The two cases were found Monday in Donggang City, more than 100 km away from the city where the disease was first reported, the Liaoning Provincial Health Department said in a statement.Health experts noted that all the cases originated from the the same source.As of 8 p.m. Monday, four cases have been confirmed while 28 others were still being investigated, according to the health department.An initial investigation by local health authorities showed that the patients contracted the disease after direct contact with diseased cattle.The government of Liaoning has since killed or disinfected more than 400 heads of cattle in the province and carried out a survey among over 20,000 people.Cutaneous anthrax is an infection of the skin caused by direct contact with infected animals or animal products. It is rarely fatal if treated.

CHENGDU, Sept. 3 (Xinhua) -- A list of this year's top 500 Chinese enterprises was unveiled in the city of Chengdu in southwest China's Sichuan Province on Saturday.The Sinopec Group was ranked first, with last year's revenues reaching 1.97 trillion yuan (307.81 billion U.S. dollars), followed by the China National Petroleum Corp. and State Grid Corp., whose revenues hit 1.72 trillion yuan and 1.53 trillion yuan last year, respectively.The rest of the top 10 was rounded out by the Industrial and Commercial Bank of China, China Mobile, China Railway Group, China Railway Construction Corp., China Construction Bank, China Life Insurance Co. and Agricultural Bank of China.The list is the 10th of its kind to be jointly released by the China Enterprise Confederation and the China Enterprise Directors Association. The threshold for entering the list was raised to 14.2 billion yuan in revenues, an increase over the 11.08-billion-yuan threshold used during the previous year.Revenues for China's top 500 companies rose 31.6 percent year-on-year to 36.31 trillion yuan in 2010, while their total assets increased by 18.4 percent to 108.1 trillion yuan, the two organizations said.The companies reported profits of 2.08 trillion yuan for last year, a rise of 38.67 percent from one year earlier.They paid 2.73 trillion yuan in taxes in 2010, accounting for 37.3 percent of the country's total tax revenues.

BEIJING, July 3 (Xinhuanet) -- The Atlantis mission to be launched by NASA on July 8 will not be an end to the space age, as some media suggest.Although it is the final mission of the space shuttle, it will open up "the next chapter" in the United States' space exploration, NASA's administrator Charles Bolden Jr said at the National Press Club in Washington on Friday."When I hear people say - or listen to media reports - that the final shuttle flight marks the end of US human space flight, I have to say . . . these folks must be living on another planet," he said."As a former astronaut and the current NASA administrator, I'm here to tell you that American leadership in space will continue for at least the next half-century because we have laid the foundation for success - and for NASA, failure is not an option," he said.NASA administrator Charles Bolden Jr drew a lot of media attention during his speech at the National Press Club in Washington DC.One of the foundations is the "unprecedented" research capabilities the International Space Station (ISS) now possesses, largely thanks to the space shuttle missions.Although some media imply that "the game will be up" once the ISS is out of orbit in 2020, he said the splendid research results and rich knowledge astronauts and scientists have accumulated through more than 1,200 experiments since 1998 have laid out "a stepping-stone to the rest of the solar system and the tip of what comes next".As NASA turns a new page, it will "focus on deep space exploration", while leaving US private companies to operate low Earth orbit transportation systems for tourism and business, he said.NASA will develop "a deep space crew vehicle and an evolvable heavy-lift rocket," he said. The moon, asteroids and Mars will be the next destinations for humans to live and work, he said."We will maintain and grow US leadership in space and derive all the benefits that flow from it. Tomorrow's space program is taking shape right now," he said.

HELSINKI, Aug. 21 (Xinhua) -- The Finnish company Spektikor has recently developed a novel type of disposable heart rate indicator, local media reported on Sunday.Different from a conventional heart rate monitor, it is a speed heart rate indicator designed for first aid professionals and specially used in first aids in major accidents, disasters and other crises.According to Spektikor, the product is consisted of a heart rate sensor with two EKG electrodes and a LED indicator, which are connected by a 35-cm-long wire.In operation, the sensor is placed on a patient's chest and the LED indicator is sticked to the patient's cheek. If the heart rate is within the normal range, the LED indicator will flash green with each beat. If the heart rate is dangerously low or high, the light will turn red.The product will help hospital staff speed up their work considerably as it is not necessary to check the pulse manually. In addition to saving time, it will also enhance safety, as the LED indicator can be seen clearly at a glance.The market prospect of the disposable heart rate indicator is quite optimistic as there is a worldwide need for the product.