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The United States has more than double the rate of premature overdose deaths of at least 12 other countries, according to a new?study.The research, published Monday in the Annals of Internal Medicine, says that there were an estimated 63,632 drug overdose deaths in 2016 in the US."The U.S. has the highest death rate due to drug overdoses for both men and women (35 deaths in 100,000 men and 20 deaths in 100,000 women) in 2015, more than double those of any other country in our study," Yingxi Chen, one of the researchers and a postdoctoral fellow at the National Institutes of Health's National Cancer Institute, wrote in an email.Mexico had the lowest rates: 1 death per 100,000 men and 0.2 deaths per 100,000 women.The researchers also found that the United States had the second-highest increase in drug overdose deaths: 4.3% per year in men and 5.3% per year in women, Chen said. Only Estonia had a higher increase.Norway was found to have the biggest decrease in drug overdose mortality for the whole population. Decreases were also found among men and women in Mexico, Spanish men and Danish women.Researchers "looked at the trends and patterns of drug overdose deaths among people age 20 to 64 years in 13 countries of the Organisation for Economic Co-Operation and Development?between 2001-2015," Chen said.These countries were Australia, Chile, Denmark, England, Wales (the data for these two countries was combined), Estonia, Finland, Germany, Mexico, the Netherlands, Norway, Spain and the United States."I think it reinforces what we know about the United States but also points out some of the contrast in terms of the ways other countries have dealt with similar issues," said Caleb Banta-Green, principal research scientist at the University of Washington Alcohol and Drug Abuse Institute, who was not involved in the research.Banta-Green and the researchers both point out that opioids play a part in the high levels of drug overdose deaths in the US.The study describes US opioid deaths as "triple epidemic waves," starting with prescription opioid deaths in the late 1990s, heroin deaths beginning in 2010 and finally deaths due to synthetic opioids, which include fentanyl.Other countries have found solutions to high rates of opioid-related deaths, according to Banta-Green, who cited France, which was not included in the research."When France got rid of the restrictions on prescribers using the medication buprenorphine, their national mortality, opiate overdose mortality rate dropped 79%," he said.Buprenorphine is a drug approved by the US Food and Drug Administration that can be used, alongside behavioral therapies and counseling, to help with the treatment of opioid addiction. It is the "first medication to treat opioid dependency that is permitted to be prescribed or dispensed in physician offices, significantly increasing treatment access," according to the US Substance Abuse and Mental Health Services Administration.Banta-Green believes that creating better access to substance abuse disorder treatments, along with a better national understanding that these are treatable medical conditions, would help reduce the number of overdose-related deaths in the US. This includes giving more people access to medications that could help treat and manage opiate addiction."That's really fundamentally what I think we need to take away from these data finding is that there are solutions, other countries have them, and we are not doing the dramatic things that we need to be doing," he said. 3565

The United States Coast Guard embodies the saying, "always ready."When forecasting natural disasters, however, those two words become much more than a motto -- they could mean the difference between life and death.“With natural disasters, they’re unpredictable," said USCG Capt. Will Watson, commander, Sector New Orleans. "There’s uncertainty but what you have to do is lean back on your training.” With U.S. Coast Guard stations across the country on standby, Watson said his teams are ready to help whenever and wherever they are needed.“When the time comes, and you face something that you maybe weren’t otherwise prepared for, that’s when you exercise on-scene initiative,” he said. “You think critically. You think creatively. Remain adaptable and flexible and act.”Southeast Louisiana locals are calling the U.S. Coast Guard, “heroes,” saying they saved more than lives during past natural disasters.“One day, I got stuck in a boat and they come over here, five of them come here, and helped me out,” said local fisherman Tony Buffone, who lost his house during Hurricane Katrina -- one of the most deadly and expensive natural disasters to hit U.S. soil.During recent storms, Buffone is now using lessons he learned from the U.S. Coast Guard.“It’s good to have good Coast Guard,” he said. “We got a good Coast Guard crew right there.”As the Gulf Coast deals with another massive hurricane, the U.S. Coast Guard is doing what it does best: staying “always ready”.“We have resources, assets, people from all across the Coast Guard ready to support this fight,” Watson said. “And we’re ready; ready to respond to Hurricane Laura.” 1643

The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The U.S. Postal Service has announced its holiday shipping deadlines as we approach a holiday season like none in our lifetime.Delivering cards and gifts through the mail may be more important than ever this year because many people will refrain from visiting loved ones to prevent the spread of the novel coronavirus.The Postal Service says you can you rely on them to deliver your parcels to family and friends, whether they’re overseas, across the country or just on the other side of town.USPS officials recommend the following mailing and shipping deadlines for expected delivery by Christmas Day to domestic addresses and Air/Army Post Office/Fleet Post Office/Diplomatic Post Office addresses:Nov. 6 — APO/FPO/DPO (all ZIP Codes) USPS Retail Ground serviceDec. 9 — APO/FPO/DPO (ZIP Code 093 only) Priority Mail and First-Class MailDec. 11 — APO/FPO/DPO (all other ZIP Codes) Priority Mail and First-Class Mail servicesDec. 15 — USPS Retail Ground serviceDec. 18 — APO/FPO/DPO (except ZIP Code 093) USPS Priority Mail Express serviceDec. 18 — First-Class Mail service (including greeting cards)Dec. 18 — First-class packages (up to 15.99 ounces)Dec. 19 — Priority Mail serviceDec. 23 — Priority Mail Express* serviceUSPS also suggests skipping the trip to your post office and using their online tools to ship your items.The Postal Service anticipates Dec. 14 will be its busiest day online with more than 13 million consumers predicted to visit usps.com for help shipping things. Officials estimate nearly 500,000 consumers will use their Click-N-Ship feature and other online services on that day to order Priority Mail boxes, print shipping labels, purchase postage and even request free next-day package pickup.The Postal Service has offered these tips for a successful holiday mailing and shipping season:Use free Priority Mail Flat Rate boxes. They are available at local Post Offices or online at usps.com/freeboxes.Make it easy with Click-N-Ship. You can create shipping labels and pay for postage online at usps.com/ship.Schedule a free Package Pickup when the carrier delivers your mail. It’s free regardless of the number of packages. Or, pickups can be scheduled at usps.com/pickup.Mail and packages that weigh more than 10 ounces and/or are more than a half-inch thick using stamps as postage cannot be dropped into a collection box or left for a carrier to pick up. Instead, take them to a window clerk at a Post Office. 2448

The sports complex sheltering thousands of Central American migrants in this Mexican border city is well above its capacity, and more migrants are expected to arrive in the coming days.More than 5,800 migrants have taken shelter in the Benito Juarez Sports Complex, according to Mexico's Social Development Secretariat.That's at least three times above the facility's capacity, said Rodolfo Olimpo, a representative from Baja California state's Special Committee on Migration Issues.State and municipal officials are looking to open another shelter, Olimpo said, but they haven't found any local business or space willing to rent out their facilities for the migrants.CNN crews that visited the Benito Juarez shelter found squalid conditions, including open sewage drains. Many people appeared restless and nervous.Inside the sports complex, which has become the main facility sheltering migrants in Tijuana, migrants wait for hours in long lines for food. Tents cover sports fields and spill outside the facility's gates.Many migrants say they're waiting for the chance to seek asylum in the United States. Given the massive backlog at the nearby port of entry, it could be weeks before they have a chance to cross the border and begin to make their case.Meanwhile, the Mexican Red Cross has been providing medical assistance for migrants in the shelter. The Mexican navy has set up two small kitchens nearby the shelter, Olimpo said, and the federal government has installed two water plants.But Amnesty International said on Monday the shelter doesn't have enough resources for migrants housed there, describing conditions as "unsanitary.""Mexican federal, state and municipal officials separately confirmed to Amnesty International that the temporary shelter did not have sufficient food, water and health services, and that respiratory illnesses were spreading among those staying there," Amnesty said.Tijuana's mayor has described the situation as a crisis and called for humanitarian help.The growing number of migrants in Tijuana, a city of about 2 million people just south of California, is "a big problem" that "we are not capable of solving," Mayor Juan Manuel Gastélum told CNN.The Mexican federal government -- with a new president due to be installed Saturday -- or the United Nations must step in, the mayor said, to "give us shelter, give them food, water, medicines, everything that a person needs to be dignified and have a place where they can stay dignified." 2488