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While scientists work to come up with a safe and effective COVID-19 vaccine, doctors across the country are watching closely. Many are helping guide their patients in making an informed decision about getting a vaccine."This was indeed a surprise to see that there would vaccines available by the 1st of November. It’s clearly an aspirational goal, because we all would like to see a safe and effective COVID-19 vaccine as soon as possible, but I think testing vaccines to make sure they’re safe and effective is of paramount importance," said Dr. Bali Pulendran, a microbiology and immunology professor at Stanford University.Dr. Pulendran says the process of developing a vaccine involves numerous steps, and scientists are getting closer to the end. Still, it's hard to put an end date on the third and final phase of a vaccine trial. This last phase determines whether the vaccine actually works."The way in which you can assess whether a vaccine works is to see how many of these people acquire the disease or become infected with COVID at some period of time," explained Dr. Pulendran.Phase three divides the trial participants into two groups. One group is given the vaccine, and the other is given a placebo."And then, you calculate the efficacy based on those numbers. So, if there were 200 people affected in the placebo group but there were only 100 people who were infected in the vaccinated group, then the efficacy is 50 percent" said Dr. Pulendran.The third phase is hard to time, as it depends on how quickly some of the trial participants become infected. If they live in areas where COVID-19 infection rates are higher, the phase will be completed faster.But there are some other ways to speed up the vaccine trial.Dr. Darria Long, an emergency room physician and clinical assistant professor at the University of Tennessee-Erlanger, says one way is by doing two of the phases at the same time. Another way is if officials prepare for the manufacturing and logistics side of producing the vaccine during the third phase of the trial."This is what we see the CDC saying is to get ready on the manufacturing and logistics side because even if you come up with the perfect target drug, making sure you can manufacture hundreds of millions and that you have the little glass vials that can keep it at the right temperature, those are all things that can be hang-ups,” said Dr. Long. “So, they're wanting to expedite that process, because the last thing you want is to say is we have the vaccine, but we can’t get it to people.”Dr. Long is already answering her patients' questions as news of a possible COVID-19 vaccine continues to be publicized."I do think a lot of people are wondering about this vaccine and it runs the gamut. There are those that say they really want the vaccine because they see it as this gateway to getting back to life as we know it," said Dr. Long.There are also those who are really concerned about the efficacy and safety of a COVID-19 vaccine. Doctors say a key piece in evaluating a vaccine when it does come out is the data surrounding it."The data that comes out in the public domain: is a particular vaccine efficacious? How effective is it what is the efficacy data? Is a particular vaccine safe? What are the side reactions? And they should talk with their physicians to ask each question. Ask doctors, ‘Could you tell me what the safety part of this vaccine is?" recommended Dr. Pulendran.And above all, doctors and scientists hope politics will stay out of the development of a COVID-19 vaccine in order to ease any concerns or hopes for a vaccine to be available as soon as possible. 3644

With New Year's Eve right around the corner, a new San Diego company says it can deliver the cure to a hangover right to your front door. But the cost-benefit of the service is up for debate. The company, called CureDash, is an app on the iPhone and GooglePlay stores. It connects San Diegans to providers that offer house calls with licensed nurses who administer an I.V. with a saline-based solution to help rehydrate. They promise to arrive within an hour. "Me and my co-founder both got it and we felt the results within minutes," said Emil Juboori, who co-founded CureDash. "You can request our service through our app. You'll have a short video call with our doctor, you'll do a quick assessment and then we dispatch a nurse to your location."Juboori said the nurses do check patients vitals and ask them health questions once they arrive at their homes. CureDash costs 5 and does not take insurance. "I wouldn't consider this to be effective medical therapy," said Dr. Shawn Evans, an emergency room physician at Scripps Memorial Hospital in La Jolla. "My strong preference is if you think you need somebody coming out to your house to put a needle into your arm to give you massive resuscitative fluids, ultimately you should be in front of a qualified medical professional and making sure you don't have something more significant."Evans said an I.V. can make you feel better in the short term, but you will urinate a good portion of the extra fluids within an hour. Evans said a trip to urgent care is likely more affordable and that he remains concerned about at-home services like these. Evans said an affordable way to rehydrate is to mix:Six teaspoons of sugarA half teaspoon of saltFour cups of warm waterEvans said to drink a mouthful every five minutes and it will stay in your system. 1814

With five weeks remaining in the college football season, the College Football Playoff selection committee unveiled the first poll, and there is little surprise at who is at the top. Alabama, the defending national champs, was ranked No. 1 in the poll released Tuesday, followed by the 2017 champs No. 2-ranked Clemson. With Alabama and Clemson both sporting unbeaten records, it is not surprising to see the two squads at the top of the ranking. But the selection committee's third choice might leave some fans scratching their head. Rather than picking unbeaten Notre Dame at No. 3, the selection committee slotted one-loss LSU as the third pick. Notre Dame, who has a win over Michigan who is ranked at No. 5 in the CFP ranking, was at No. 4. With the toughest part of Notre Dame's schedule in the past, and no remaining Top 25 games remaining on the schedule, the Irish's chances of making the College Football Playoff are in question given that a one-loss team is already ahead of Notre Dame. A group of other one-loss teams are poised to potentially overtake Notre Dame at the No. 4 spot since most of those squads will get the opportunity to play in a conference title game. With Notre Dame being an independent, the Irish do not get the benefit of playing in a conference championship. Behind Michigan is a quintet of teams sporting 7-1 records going into Week 9. Those teams are No. 6 Georgia, No. 7 Oklahoma, No. 8 Washington State, No. 9 Kentucky and No. 10 Ohio State. UCF, who is the only other unbeaten team besides Alabama, Clemson and Notre Dame, was ranked No. 12. The top four teams at the end of the season advance to play in the College Football Playoff.  1728

Whoa. Just after noon, a BIG fireball flashed through the sky over Niagara. The @EarthCam CN Tower cameras caught the flash from it at ~12:03:32! Wow, it was bright!#Fireball @amsmeteors pic.twitter.com/6piLtC1Kqt— Scott Sutherland (@ScottWx_TWN) December 2, 2020 271

What happened to Katie Hill shouldn’t happen to anyone. But, this moment requires more nuance, as Katie Hill’s story - our story - is also one of workplace abuse and harassment.— Rep. Katie Hill (@RepKatieHill) October 7, 2020 235

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