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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) — Looking for a laugh? It is, after all, the best medicine, right?There's plenty of belly shaking humor to be discovered around San Diego. From open mic nights to nationally-known comics being showcased, locals can find it all at our city's comedy clubs.If you're looking for a spot to sit down, have a drink, and spit-take that drink, here's where you'll find the fun around town:The American Comedy Co.: 818 B 6th Ave., San DiegoAMC is located in the heart of the Gaslamp District, giving guests to chance to spend the night downtown and enjoy laughs with little travel time between activities. The club's underground feel also gives it a speak-easy, intimate vibe. | ScheduleThe Comedy Store: 916 Pearl St., La JollaDavid Letterman threw out the first joke to usher in the famed Comedy Store's La Jolla digs in 1977. The comedy spot gives visitors the comfort of a night near a scenic view of the Pacific while enjoying some laughs. | ScheduleThe Mad House Comedy Club: 502 Horton Plaza, San DiegoNational and local comics take the stage at Mad House most nights every week in Horton Plaza. | ScheduleThe Comedy Palace: 8878 Clairemont Mesa Blvd., Kearny MesaCheck out a lineup of local and nationally-featured comics taking the stage in Kearny Mesa at The Comedy Palace. | ScheduleThe Comedy Club at Pechanga: 4500 Pechanga Pkwy., TemeculaPechanga Resort Casino's Comedy Club brings together some of the comedy circuit's brightest stars and up-and-comers, offering comedy and dinner packages as well. | ScheduleSycuan Live & Up Close: 3007 Dehesa Rd., El CajonNational comedians hit the stage at Sycuan Resort & Casino's Live & Up Close performances. | ScheduleNational Comedy Theatre: 3717 India St., San DiegoImprov comedy and entertainment for all ages from national troupes can be seen at National Comedy Theatre. | ScheduleWinston's Beach Club: 1921 Bacon St., Ocean BeachOpen mic nights, comedy showcases, and roast battles are held weekly at Winston's in OB. | Schedule 2017

SAN DIEGO (KGTV) — It's already been one year since the San Diego Zoo Safari Park saw the first southern white rhino born through artificial insemination arrive at its park.Edward turned one-year-old on July 28, celebrating with a party at the San Diego Zoo Safari Park’s Nikita Kahn Rhino Rescue Center with his mother Victoria, 8-month-old female calf Future, and her mother Amani."Even though he doesn’t know it’s his birthday, it is very special to see Edward – a healthy, robust rhino - running around, enjoying his special treats," said Barbara Durrant, director of Reproductive Sciences at San Diego Zoo Global. "We aren’t just celebrating his birthday but also are celebrating the significance of his birth."Edward was born last year after hormone-induced ovulation and artificial insemination with frozen semen from southern white rhino Maoto on March 22, 2018. Victoria gave birth 16 months later. Edward's birth was the zoo's first successful attempt to birth a southern white rhino via artificial insemination and a critical step toward recovering its distant cousin, the northern white rhino. Currently, only two northern white rhinos exist in the world and both are female.Researchers believe that a northern white rhino calf could be born from artificial insemination within 10 to 20 years. 1313

SAN DIEGO (KGTV) — It's been a tumultuous year for East Village's Monkey Paw Brewery.The local brewing company was purchased by Coronado Brewing Company in July 2017, put up for sale in May of this year, and closed its downtown San Diego brewpub Monday.Coronado Brewing Company (CBC) CEO Brandon Richards said in May, months after finalizing the purchase, the sale was part of a refocusing for CBC.RELATED: Miramar's Intergalactic Brewery is closing its doors"While we were excited about the potential of Monkey Paw, the decision to sell came from the need to refocus our energy toward Coronado Brewing," Richards said. "We’re confident that the award-winning Monkey Paw brewery has brand equity that can be of value to someone looking to enter the craft industry."CBC said they would keep the downtown brewpub open while fielding offers for Monkey Paw.However, Richards told 10News Tuesday they are still looking for a buyer for the brand and are now determining the best use for Monkey Paw's former space.Richards added that CBC is currently producing Monkey Paw beers on an as needed basis.RELATED: Novo Brazil Brewing announces new?Chula Vista locationMonkey Paw had amassed a list of awards, including wins at the San Diego International Beer Competition, Los Angeles International Beer Festival, Great American Beer Festival, and World Beer Cup.Though soon after CBC's purchase of the brand, Monkey Paw's founder Scott Blair filed a lawsuit against Monkey Paw for breach of contract, according to Brewbound.Blair claimed Monkey Paw owed him ,534, plus interest, as part of a promissory note. Blair said he had not received any payments, which were to be made monthly, since Oct. 2017.At the time CBC announced the sale, Richards told Brewbound the decision was not a result of the pending lawsuit. 1859

SAN DIEGO (KGTV) - If you run a small business, there’s a good chance you can find affordable office space. But what you may not find is flexibility, and you could get stuck with a long-term lease. Or, you could consider one of the many co-working spaces around San Diego. 10News is taking a closer look at that option in our quest to help you Make it in San Diego. "This is a tiny, skinny office that can seat two people but that's all we need," says Kyle Carpenter looking around his 15-feet by 6-feet office.Carpenter is CEO of SolidSurface.com"So yeah, we just launched this," adds Carpenter showing off his new website design. RELATED: Tips to help you work from homeSolidSurface.com is an online market place for decorative kitchen and bathroom surface material sold directly to consumers. Carpenter founded his small business in 2007 and used to run it out of his home. But, one thing was missing. "I needed a space to work, but it was also very important to be around other people," says Carpenter.He found that social interaction and affordable shared office space at Cross Campus near downtown San Diego. "That's why we exist, to bring people together. So, people can be productive in this space and also help each other out," says Briana Tovey, Senior Campus Manager at Cross Campus in San Diego. Cross Campus also has locations in Los Angeles and Scottsdale and each office has the space to host larger events. The shared office space here in San Diego is over 20-thousand square feet housing about 250 members."First of all, we're in Little Italy, which is very cool," adds Tovey with a smile. Going to work within walking distance to the city’s trendiest restaurants, cafes, and bars is an excellent start. An entrepreneur, a writer, any small business for that matter can use a desk for as little as 0 a month. From there, think a la carte for office space. And as your company grows, Cross Campus has the space to help you do so. In addition, for small businesses just trying to navigate through growing pains, there is no long-term commitment. "One of the benefits of our space is that we’re super flexible,” says Tovey. “So, you don't have to commit to a 3-year lease or even a 1-year lease.” You also avoid the cost of a complete build out. Your desk, internet, printing, coffee, snacks, kitchen, they're all provided. Plus, the occasional community happy hour. You can't get that at home. "To be able to be around this sort of creative, vibrant community," says Carpenter "It’s kind of inspiring."Cross Campus will give you a tour of their San Diego location if you're in the market for shared office space. There are also numerous co-working spaces throughout San Diego County. Below are just a few that might fit your needs: CommonGrounds is located in Carlsbad conveniently across from the Poinsettia Coaster Station. This site captures the California work-life with expansive outdoor seating and patio area centered around INVITA café. Their on-site chef cooks daily organic specials that pair beautifully with the cafe's Italian espresso beverages. CommonGrounds features private offices, traditional co-working, and meeting spaces housing over 200 members representing over 100 companies.WeWork has locations in La Jolla UTC and Downtown.Premier Workspaces has locations in Downtown, La Jolla, Del Mar, Mission Valley, and Rancho Bernardo.Regus offers both Commercial Office Space and Co-working space. 3443