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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.
HANOI, Oct. 25 (Xinhua) -- The hand-foot-mouth disease (HFMD) and dengue were on the rise across Vietnam, reported the Vietnam Preventive Medicine Administration (PMA) on Tuesday.As of Oct. 23, the country had more than 76,120 HFMD patients and 135 fatalities. The number of incidents has increased significantly over the last few weeks, with an average of 2,000-2, 500 new cases reported each week.Southern Ho Chi Minh City and Binh Duong, Long An and Quang Ngai were the most-hit localities, said the report.Meanwhile, dengue was also reported on the rise. In the first ten months of the year, there were more than 41,200 infected cases and 32 fatalities. Currently, an average of 2-3 cases a day were hospitalized by dengue infections, mainly from capital Hanoi.Epidemiologists said that the increase of HFMD and dengue was due to the lack of specialized medicine and preventive vaccines. In addition, complicated climate change, environment pollution and low awareness of the disease among the community have contributed to the spread of the diseases nationwide.
WASHINGTON, Oct. 18 (Xinhua) -- Heart failure (HF) hospitalizations dropped 29.5 percent nationally over the past decade, according to a study by Yale physicians to be published Wednesday in the Journal of the American Medical Association.The risk-adjusted rate of heart failure hospitalization fell from 2,845 to 2,007 per 100,000 person-years from 1998 to 2008 in a fee-for-service Medicare claims analysis by Dr. Jersey Chen of Yale University and colleagues.The team also found that the rate of hospitalization for black men dropped at a lower rate, and that one-year mortality rates declined slightly during that period, but remained high.HF imposes one of the highest disease burdens of any medical condition in the United States and the risk increases with age. As a result, HF ranks as the most frequent cause of hospitalization and re-hospitalization among senior Americans. HF is also one of the most resource-intensive conditions, with direct and indirect costs in the United States estimated at 39.2 billion U.S. dollars in 2010.The study showed that the HF hospitalization rates varied significantly from state to state. The decline in the hospitalization rate from 1998 to 2008 was significantly higher than the national average in 16 states and significantly lower in three states (Wyoming, Rhode Island and Connecticut).Chen and his team also found that risk-adjusted one-year mortality decreased from 31.7 percent to 29.6 percent between 1999 and 2008, a relative decline of 6.6 percent, with substantial variation in different states."Because of the substantial decline in HF hospitalizations, compared to the rate of 1998, there were an estimated 229,000 fewer HF hospitalizations in 2008," said Chen in a statement, adding that with a mean HF hospitalization cost of 18,000 dollars in 2008, this decline represents a savings of 4.1 billion dollars in fee-for-service Medicare."The overall decline in the heart failure hospitalization rate was mainly due to fewer individual patients being hospitalized with heart failure rather than a reduction in the frequency of repeat hospitalizations," said Chen.
TAIYUAN, Jan. 9 (Xinhua) -- China successfully launched the Ziyuan III satellite Monday from the Taiyuan Satellite Launch Center in northern Shanxi province.The satellite, a high-resolution remote-sensing satellite for civilian use, was launched at 11:17 a.m. aboard a Long March 4B rocket, according to a statement from the center.The satellite, weighing 2650 kg, entered an orbit of 500 km above the Earth about 12 minutes after it was launched. It has a designed life expectancy of five years.According to the center, the satellite is tasked with offering services to aid the country's land-resources surveys, natural-disaster prevention, agriculture development, water-resources management, and urban planning.The rocket also carried a satellite from Luxemburg, according to the launch center.The orbiter was developed and produced by the China Academy of Space Technology, a subsidiary of China Aerospace Science and Technology Corporation (CASC).The Long March 4B rocket is developed by Shanghai Academy of Spaceflight Technology, another CASC subsidiary. Monday's mission marked the 156th flight of China's Long March series of carrier rockets.
SHANGHAI, Nov. 28 (Xinhua) -- The Shanghai municipal government Monday launched the microblog "Shanghai City" on China's popular Twitter-like microblogging service Weibo.com.The microblog, officially verified as originating from the Information Office of Shanghai Municipal Government (IOSMG), has accumulated more than 30,000 followers in the five hours since its launch.According to IOSMG, the content of the postings will be mainly about new policies and regulations, practical information related to activities in Shanghai, and interactions with Internet users over issues of public concern.Vegetable prices, the selection of affordable housing, and upcoming cultural activities in Shanghai are included in the first several postings.Some 600 government agencies and 300 government officials of various levels in Shanghai have verified Weibo accounts, the IOSMG said.The "Shanghai Metro," the official microblog of the city's metro operator with over 1.15 million followers, is considered one of most influential government microblogs in China.The latest statistics show that China now has more than 300 million registered microblog users. Related:Beijing city gov't opens press release microblogging platformBEIJING, Nov. 17 (Xinhua) -- The Beijing municipal government Thursday launched a news release platform on Sina's weibo.com, China's popular Twitter-like microblogging service.Twenty municipal government agencies will post newly-unveiled policies and regulations, work developments, and information of news conferences on the joint microblog account, said Wang Hui, head of the Beijing municipal government's information office.