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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) - Less than a week before the election, there are reports of political yard signs being stolen and vandalized, and in some cases, appearing in yards.Sunday night, just before midnight in a cul-de-sac in El Cajon, surveillance video shows a car driving slowly before it stops to let someone out."A shadowy figure, looks young, maybe 10 years old, gets out of the vehicle, runs in, and grabs a political sign," said Brandon Spaulding.Spaulding says the sign being taken belonged to his neighbor and it read "Trump/Pence, Make America Great Again." That same night, Spaulding's sign, which had been vandalized days before, also disappeared.The apparent thieves in the Sunday's thefts: a child and an adult."Very disappointed and frustrated ... being a terrible role model. As parents, you’re supposed to teach children the different between right and wrong. I was always taught to love my country, and part of that is freedom of speech. Respect people's rights to say what they want to say," said Spaulding.Spaulding isn't alone. Local Republican Party officials say they've received more than a 100 reports of stolen Trump signs, a greater number when compared to previous presidential elections.In Coronado, police responded Wednesday to seven homes, where yard signs reading "Racism Lives Here" appeared in front of the homes of Trump supporters who were displaying signs or flags.It isn't just Trump backers being targeted. On the Nextdoor mobile app, ABC 10News found numerous examples of signs supporting presidential challenger Joe Biden stolen.Just south of Balboa Ave., Margo Thomas woke up Wednesday to her Biden/Harris yard sign gone."To me, it just feels like you’re stifling free speech," said Thomas.There is still no mistaking who Thomas is backing. A "California for Biden" sign still stands in her yard.In El Cajon, Spaudling immediately purchased new Trump signs for his yard and for two neighbors.ABC 10News reached out to the local Democratic Party officials for theft numbers and are waiting to hear back.Campaign sign theft does qualify as misdemeanor petty theft, which carries with it a maximum penalty of six months in jail. 2171

SAN DIEGO (KGTV) — Jessica Mattly was all smiles Thursday, ironically, thanks to the state Employment Development Department.“For the first time they called me,” she said. “I didn't call them. It was great.”A representative from the EDD, which issues unemployment insurance payments, called Mattly to tell her that they finally processed her application for jobless benefits. They’d begin by sending her four weeks of backpay.Mattly’s had been trying to get through to the EDD since she lost her job at a San Diego resort in late March, when Coronavirus restrictions went into effect. She filed for unemployment immediately, but like thousands of other San Diegans, got a request from the EDD for identity verification.She submitted the necessary documents, but never heard anything back.“I would just keep dialing, and keep dialing, and keep dialing, and I understand the definition of insanity. I do. And it felt like that was my only option,” she said.Mattly kept running into walls, until she turned to State Sen. Ben Hueso’s office, which contacted the EDD on her behalf.That lead to Thursday's phone call.Others, like Audee Kammer - just wouldn't take no for an answer.The EDD denied her identity documentation twice. She called hundreds of times - finally appealing the denials and getting a telephone hearing with a judge, who authorized payments.“I could see how some people, it could just throw them into deep depression and despair,” she said. “I feel for a lot of people out there that are in my same situation that I was and don't have the drive to keep knocking on that door.”Meanwhile, the latest state numbers show more than 230,000 San Diego County residents are unemployed.The EDD says its funding has increased drastically since the pandemic began and is now undertaking a massive hiring effort.It has filled 900 new positions to process an unprecedented amount of claims - with an additional 1,900 openings.Sen. Hueso represents the 40th Senate District, which includes portions of the County of San Diego and all of Imperial County. If you don't reside in District 40, you should contact your elected representatives for your area. To find your representative, click here. 2201

SAN DIEGO (KGTV) — It's sure to be a super summer next year in Del Mar.The San Diego County Fair announced its 2020 season will be themed "Heroes Unite!" when the fair soars into the Del Mar Fairgrounds from June 5 to July 5, 2020."You’ll soar through the air on adrenaline-pumping carnival rides, strike a power pose with your favorite superheroes, taste your way through the Fair’s superfoods, discover entertainment surprises around every corner, learn the science and history of being a superhero and meet real-life community heroes who put Clark Kent to shame," the fair's website reads.RELATED:Carlsbad Strawberry Field and Pumpkin Patch holds decades of family historyMission Hills home transformed into whimsical topiary gardenLa Jolla taco stand named among America's best fast-casual restaurantsAs hinted in the description, the fair is also looking for locals to nominate community heroes who will be honored throughout the fair's run. Nominations can be submitted here.The fair's exhibits will also likely take a superhero slant, as guests learn the "science and history" behind superheroes. And where better to learn than the home of San Diego Comic-Con?And, of course, themed foods are sure to make an appearance from vendors like Chicken Charlie, Bacon-A-Fair, and Pink's Hot Dogs.Before the year is even up, the fair is also offering discounts on admission, attractions, and parking. For more information on the fair, performers, and attractions, visit sdfair.com. 1488

SAN DIEGO (KGTV) -- Inclement weather beginning Monday and lasting through Thursday will bring cooler temperatures and rain to San Diego County amid a busy travel season. The first of a series of storms is set to arrive Monday, bringing rain and snow to the county. A second storm is due to bring another round of moisture Christmas night through Thursday. Between the two storm systems, light showers will occur, according to the National Weather Service. The first round of storms are forecast to dump as much as an inch of rain along the coast and in the mountains. RELATED: Check your San Diego County Forecast | Holiday traffic mapSnow levels will be between 5,500 and 6,000 feet through Monday, falling to near 5,000 feet early Tuesday. Snow accumulations between one and three inches are expected for elevations between 5,000 and 6,000 feet. Another storm arriving Christmas night and lasting through Thursday shows similar precipitation amounts, according to model data. The agency says the second storm is colder, which means it could have a greater impact in the mountains, including through the Cajon pass and I-8 across the San Diego County mountains. 1172

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