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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

JERUSALEM, Jan. 12 (Xinhua) -- An Israeli company has developed a system that scans the brain and provides a three dimensional image of the nerve cell connectivity to treat brain diseases like Alzheimer's or HDHD.The firm ElMindA trademarked a non-invasive system, the BNA ( Brain Network Activation), that helps doctors visualize the connectivity between nerve cells and synchronization that can even measure the severity of the patients condition from one day to another, the Israel21c news site reported on ThursdayBy creating a three-dimensional image of the brain while asking the patients to repeat an activity several times, BNA developers hope this system will become a regular way of diagnosing brain illnesses."Our vision is that every psychiatrist and neurologist in the world will routinely send every patient for BNA tests," said Dr. Eli Zangvil, ElMindA's strategic advisor for business development. "Our test would add information and aid in diagnostics in a way no other existing technology can do," he added.BNA could help doctors find out exactly at what stage of the disease patients and prescribe the exact medication for them."To do that, we must collect a lot of data," Zangvil said. "To say this person has a certain disease or condition, I have to be able to compare their pattern to a normal brain pattern of a person of the same age and gender." he said.Researchers hope to gather the amount of data they need to obtain FDA approval in the U.S. by the end of 2012, and start marketing it to hospitals by 2013.

SANTO DOMINGO, Sept. 30 (Xinhua) -- Haitian health authorities on Friday said the number of deaths caused by cholera increased to 6,435 in the Caribbean country since October 2010.The Haitian Health Ministry said the number of people infected with cholera almost reached half a million, although the ministry repeated the epidemic was decreasing.The report said 455,727 people had been treated due to cholera, and 242,205 had to be hospitalized.The western province of Artibonite suffered the plague most with 1,196 deaths. The southwest province of Nippes registered the smallest death toll of 181.Meanwhile, in the Haitian capital Port-au-Prince, 221 people have been killed since October 2010 when the epidemic first broke out in central Haiti.The epidemic is supposedly due to the spill of dregs from a Nepalese camp, which is part of the UN Stabilization Mission in Haiti (MINUSTAH).The Dominican Republic, a country neighboring the island country Haiti to the east, has also been suffering the disease since November 2010, which has killed at least 135 people there.

BEIJING, Otc. 26 (Xinhuanet) -- The more coffee people consume, the less likely they develop the most common form of skin cancer, a new study suggests, according to media reports Tuesday."Our study indicates that coffee consumption may be an important option to help prevent basal cell carcinoma," stated Fengju Song, lead researcher of the study and a postdoctoral fellow in the department of dermatology at Brigham and Women's Hospital and Harvard Medical School in Boston.Basal cell carcinoma (BCC) is reported to be a slow-growing form of skin cancer that accounts for 75 percent of all skin cancers. It is the most common type of skin cancer, with nearly one million new cases diagnosed each year in the United States.Although BCC is hardly fatal, if ignored, there may be consequences of treatment, including disfigurement, according to a USA Today report.The US researchers found that women who drank over three cups of coffee a day were 20 percent less likely to develop BCC, whereas the risk of having BCC for men who consumed more than three cups per day lowered 9 percent.To get the findings, the researchers analysed data from almost113,000 people between1984-2008 and over 23,000 were diagnosed with BCC.The researchers agreed that caffeinated coffee was associated with BCC risk reduction, but decaffeinated coffee did not have such effect.According to a Fox News report, besides cutting the risk of skin cancer, coffee consumption has also been found to lower the risk of breast cancer and prostate cancer and cancer overall."To the best of our knowledge, coffee consumption is a healthy habit," said Fengju Song, cited by the Fox News.The findings were presented Monday at the American Association for Cancer Research International Conference in Boston and not yet published in a scientific journal.

SAN FRANCISCO, Oct. 7 (Xinhua) -- The funeral for Apple co-founder Steve Jobs, who died Wednesday at the age of 56, is taking place on Friday, U.S. media reported.The funeral is termed as a small private gathering, The Wall Street Journal quoted a person familiar with the matter as saying.The source would not disclose where or when the event was taking place, citing respect for Jobs and his family's privacy.Apple said it has no public services planned for Jobs. In an e- mail sent to Apple staff on Wednesday, Chief Executive Officer Tim Cook said "a celebration of Steve's extraordinary life" would be held soon for employees.On its website, Apple has encouraged people to send their memories and condolence to a special e-mail address.Meanwhile, online magazine deadling.com reported Friday that Sony Pictures is making a hefty deal to acquire feature rights to "Steve Jobs," the only authorized biography of the Apple co- founder which will be published on Oct. 24.