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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

BEIJING, Jan. 12 (Xinhua) -- China's consumer price index (CPI), a main gauge of inflation, rose 4.1 percent year-on-year in December, down 0.1 percentage point from November on falling non-food prices, the National Bureau of Statistics (NBS) said Thursday.The CPI was up 5.4 percent in 2011 from the previous year, well above the government's full-year inflation control target of 4 percent, the NBS said in a statement on its website.The inflation rate in December marked a five-straight-month decline after hitting a 37-month high of 6.5 percent in July amid government tightening measures, according to the NBS data.On a monthly basis, the cost of living dipped 0.2 percent in December, while prices of entertainment, educational and cultural articles and services dropped 0.3 percent, the NBS said.Food prices, which account for nearly one third of the basket of goods in the nation's CPI calculation, went up 9.1 percent year-on-year in December and 1.2 percent month-on-month, the NBS said.The December inflation figure was in line with the market expectation, as many economists forecast that the CPI would grow around 4 percent year-on-year in December.China's Producer Price Index (PPI), a major measure of inflation at the wholesale level, rose 1.7 percent in December year-on-year, further weakening from 2.7 a month earlier.China has made controlling prices a top priority last year and implemented a series of measures to address the issue, including tightening monetary policy, cracking down on speculation, increasing food supplies and reducing circulation costs.

BEIJING, Dec. 30 (Xinhua) -- China's quality watchdog said Friday that the latest checks by testing organizations did not find excessive levels of aflatoxin in milk products made by Chinese dairies.The special checks were launched after the General Administration of Quality Supervision, Inspection and Quarantine (AQSIQ) reported on Dec. 23 that two batches of milk products made by two separate domestic dairies, including heavyweight Mengniu Dairy Group, were found to contain high levels of the cancer-causing toxin.A brief statement on the government agency's website Friday said the checks have covered major makers, including Mengniu, Yili Industrial Group, Bright Dairy, and Sanyuan Food.An AQSIQ official said earlier the toxin had originated from cows eating mildewed feed, citing reviews by experts. The toxin would disappear if the animals stop eating the rotten feed, the official said.Aflatoxin is produced by a fungus that commonly grows on crops such as grain and peanuts. High levels of the toxin may lead to cancer in some animals.

SHANGHAI, Dec. 9 (Xinhua) -- China's homegrown C919 large passenger plane has finished its preliminary development review and entered the development phase, a senior executive of Commercial Aircraft Corporation of China Ltd. (COMAC) in Shanghai said Friday.An expert team of the C919 project has approved the overall preliminary development review (PDR) of the passenger jet, said Jin Zhuanglong, president of the Shanghai-based COMAC.It is expected that the manufacturing process for the components of the prototype will begin by the end of 2011.COMAC signed a deal to sell 20 C919 large passenger planes to China Aircraft Leasing Company Limited (CALC) on Thursday.Up to now, the users of C919 large passenger planes have reached 10 and total orders amount to 215 units.COMAC said earlier it would develop both 168-seat and 156-seat models of the jet, with more models to be developed in the future.It also said that test flights for the single-aisle C919 were scheduled for 2014, and delivery is slated for 2016.

BEIJING, Jan. 8 (Xinhua) -- China started the Spring Festival peak travel season Sunday, with tens of millions of passengers, mainly migrant workers and college students, on the move in the world's largest seasonal migration.The Spring Festival, or Chinese Lunar New Year, fall on Jan. 23 this year. It is the most important traditional Chinese festival for family reunions.A total of 3.16 billion passenger trips are expected during the 40-day peak travel season, or Chunyun (Spring transportation) in Chinese, up 9.1 percent from a year earlier, according to the National Development and Reform Commission.

来源：资阳报