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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

BEIJING, Feb. 13 (Xinhua) -- Snow fell again in Beijing Saturday night, three days after the city had its first snow this winter.Snow continued falling on Sunday morning but was forecasted to stop in the daytime.From 8:00 p.m. Saturday to 8:00 a.m. Sunday, precipitation in Beijing averaged 1.7 mm to 3.1 mm in downtown areas, local meteorologists said.Zhang Qiang, head of the municipal artificial weather intervention office, said the office began cloud seeding and was continuing efforts to increase snowfall from 7:25 p.m. Saturday in the nine districts and counties of Miyun, Mentougou, Yanqing, Haidian, Pinggu, Changping, Shijingshan, Fangshan and Huairou.By 8:20 a.m. Sunday, 657 silver iodide rods had been used to increase the snowfall.More than 3,583 people and 768 vehicles have been mobilized since Saturday to clear the snow on major roads of Beijing to ensure road transportation, according to the city transportation departments.Beijing had its first snow of the winter Wednesday and Thursday after 108 days of zero precipitation.Meteorologists said the snowfall in Beijing had helped ease the pressure of drought."Beijing is expected to have another cold front from Feb. 15 to Feb. 16, but it is not sure if there will be another snowfall then," said Liao Xiaonong, chief weatherman with the Beijing Meteorological Bureau.

BEIJING, March 4 (Xinhuanet) -- Well-educated and well-paid single Chinese women were at the forefront of a boom in travel by the country's women in 2010.According to the 2010 Trend Report of Women's Travel, the amount of travel by Chinese women increased by 20 percent last year, with well-educated and well-paid single women becoming the main force in the tourism market.Travel expenditure per capita by women on the Chinese mainland was 4,300 yuan (5) in 2010, and the 20-percent year-on-year rise was much larger than the 9- percent increase for men.Qunar.com, the world's largest online travel search engine in Chinese, released the report. The Beijing-based site was launched in 2005. According to Dai Zheng, vice-president of Qunar.com, women's growing spending power has led to more of them choosing travel as a way to cosset themselves, especially well-educated and well-paid single women, who travel for relaxation and self-improvement.Zhang Jing, 31, who works for a consulting company in Shanghai and earns nearly 20,000 yuan monthly, spent 15,000 yuan on travel last year, including a trip to the Tibet autonomous region in Southwest China and another to Singapore."Travel not only releases work pressure, but also opens up my horizon on the world. I like to see and experience how others live," said Zhang, who plans to visit Thailand in May with two female friends who are both around 30 years of age."Women are active in all of our travel projects. I definitely feel that it's mostly women who are interested in our products," said Zhao Huijin, who works in the booking center of the E-commerce department of China International Travel Service (CITS).Zhao's remarks to China Daily were echoed by the report, which said more than 65 percent of decisions about travel products and travel expenditure were made by women.In addition, women tended to be more demanding of hotels, and preferred to comment and find fault with hotels. On the forum at Qunar.com, women made nearly 70 percent of the comments on hotels.Women's more active participation in travel means that when the industry's decision-makers develop new travel products they take greater note of women's views about travel.In recent years, products targeted at women have appeared, such as women's hotels, certain hotel floors especially reserved for women, and travel themed around shopping, healthcare and relaxation.Le Meridien, a five-star hotel in Xiamen, Fujian province, set up a floor tailored for women customers in July 2010.Adding to the high quality of certain facilities that women care about most, such as excellent sound insulation, the 32 suites on this floor are also equipped with products especially for women, including fresh fruits, low-calorie food, yoga mats, bath salts, facial masks and hangers for silk clothes."These rooms are warmly appreciated by ladies, and we hope to meet women customers' needs both physically and psychologically through appropriate care," said Wang Yan, assistant manager of the hotel's marketing and communication department.The report also revealed that women's choice of destination is strongly influenced by fashion. They enjoy traveling to scenic spots featured in the latest romantic movies and TV dramas.

FUZHOU, Feb. 5 (Xinhua) -- A minibus rolled over and fell into a reservoir in Shaowu City in southeast China's Fujian Province Friday afternoon, killing 10, local officials said early Saturday morning.Nine people were rescued, and two were still missing.The minibus bound for Shaowu from Yong'an lost control at 5:27 p.m. Friday when the driver apparently tried to avoid a motorbike. It fell into the Qianling Hydropower Station reservoir, according to officials with Nanping city government.About 200 police and rescuers were still looking for the missing people, and the investigation into the accident is underway.

TOKYO, Feb. 6 (Xinhua) -- Japanese Prime Minister Naoto Kan said Sunday that Japan is ready to reconstruct relations with China in cultural, economic, political and other areas, the Jiji Press reported."This year marks the 100th anniversary of China's Revolution of 1911, and next year will be the 40th anniversary of the normalization of Sino-Japanese relations," said Kan at the first session of the "China-issue" advisory committee, organized by the Japanese government and attended by personages from economic, cultural and academic circles."On this special occasion," Kan said, "Japan is ready to rebuild relations with China in various areas such as culture, economic and politics."According to local media reports, participants at the meeting put forward suggestions such as "China is a promising market in the economic area, and ties with China are thus of great importance" and "people-to-people exchanges need to be promoted in areas of culture, sports and arts."The committee is scheduled to submit the final advisory report to the government in mid-April.

来源：资阳报