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The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The University of Washington’s Institute for Health Metrics and Evaluation has been issuing frequent projections since March in an attempt to model the spread and impact of the coronavirus across the world.The models have been used by the CDC and White House coronavirus task force in an effort to better understand the potential number of deaths the coronavirus could cause.On Friday, the model added a new variable, one that could cause a steep decline of coronavirus deaths throughout the US. The IHME’s newest model, which predicts the number of coronavirus deaths in the US through the end of March, is now weighing the potential impact of vaccines on the virus.For those hoping for an immediate drop in hospitalizations and deaths caused by the coronavirus as soon as vaccinations begin later this month might be disappointed. The IHME's model shows the initial batch of vaccinations will have a relatively muted effect on deaths and hospitalizations initially. While by April 1, much of the general US population will likely not be fully vaccinated, many in the high-risk category should expect to vaccinated by then. How fast they get vaccinated will play a role in determining the number of coronavirus deaths in the US.As of Friday evening, there have been over 278,000 coronavirus-related deaths reported throughout the US, per Johns Hopkins University data. Without any vaccines reaching Americans, the IHME’s model projects a total of 548,000 would die from the coronavirus through April 1, meaning 270,000 deaths between now and then.If COVID-19 vaccines are distributed at expected levels, 9,000 lives would be saved by April 1, reducing the number of deaths between now and then to 261,000. But a rapid vaccine rollout – one that would vaccinate the high-risk population and begin to vaccinate the general population by the spring -- would result in 250,000 deaths between now and April 1.“Mass scale-up of vaccination in 2021 means we have a path back to normal life, but there are still a few rough months ahead,” said Dr. Christopher Murray, IHME director. “We must be vigilant in protecting ourselves at least through April, when, as our projections indicate, vaccines will begin to have an impact.”In the meantime, Murray says universal mask wearing and social distancing will save more lives than a potential vaccine in the next four months.“Especially in the Northern Hemisphere, it’s crucial for governments to impose or re-impose mandates that limit gatherings and require masks. Where the winter surge is driving spikes in infections, there will be many people who can still become infected and possibly die before the vaccine is fully rolled out,” said Murray.To see the IHME’s state-by-state projections for deaths, hospitalizations and cases, clickhere. 2790

The Trump campaign has dropped a lawsuit in Arizona in which they were requesting a review of ballots cast on Election Day.The lawsuit was filed Saturday and claimed some voters were worried their ballots didn’t count correctly if the machines classified a race as “overvoted”, where more than one selection was made by mistake.A judge in Phoenix held a six-hour evidentiary hearing Thursday in the case. Later that night, CNN reports, the lawyer for the Trump campaign revised their earlier request and said they would only seek a review of vote counts if the number of “overvotes” exceeded the margin of victory.In paperwork filed with the court Friday morning, the secretary of state and officials with Maricopa County noted that the difference in votes between President-elect Joe Biden and President Donald Trump is 11,414 votes, with 10,315 ballots left to be counted.They also said 191 votes classified as “overvotes” in the presidential race, and they said that number is consistent with previous elections.Friday, lawyers for President Trump’s reelection campaign dropped the lawsuit, filing a notice of “partial mootness” with the court."Since the close of yesterday's hearing, the tabulation of votes statewide has rendered unnecessary a judicial ruling as to the presidential electors," wrote Kory Langhofer, a lawyer for the Trump campaign, in court papers. The lawyer said he did want the judge to rule on their requests to review votes for two down-ballot races. 1485

The sudden and abrupt breakdown of the US Postal Service has unfolded in recent days as Democrats call for a funding boost ahead of this year’s presidential election.On Friday, the USPS announced a temporary price increase in some services from Oct. 18 until Dec. 27. The rate hike affects commercial services, as retail services are not affected.Meanwhile, the USPS has been removing mailboxes and processing machines. The machines and mailboxes are being removed across the country, according to local reports from a number of Scripps stations.On Friday, CNN and the Washington Post reported that a number of states have received letters from the Postal Service warning that they might not have the ability to ensure ballots are sent and returned in a timely manner. The warning comes as more Americans are expected to utilize mail-in voting due to the coronavirus pandemic.“The Postal Service is asking election officials and voters to realistically consider how the mail works,” Martha Johnson, a spokeswoman for the USPS, said in a statement to the Washington Post.Despite requesting a mail-in ballot himself for next week’s Florida primary, President Donald Trump has tried to sow doubt in recent weeks over the reliability of mail-in voting, claiming that the process is ripe with fraud. But there has been limited evidence to suggest his fears are founded.With the postal service facing financial troubles due to rising pension costs and decreasing usage, Trump said he would agree to funding the Postal Service, but would need some concessions from Democrats."Sure, if they gave us what we want. And it’s not what I want, it’s what the American people want," Trump said Friday. 1694

The U.S. will finish the month of November with more than 4 million confirmed cases of COVID-19, by far the most it has recorded in any month since the beginning of the pandemic.According to a database kept by Johns Hopkins University, the U.S. recorded 4.3 million new cases of COVID-19 throughout the month of November. That represents more than 30% of the 13.3 million cases recorded throughout the country since the virus reached the U.S. in February.Throughout November, the U.S. set 10 daily records for newly-reported COVID-19 cases. The peak came on Friday, when Johns Hopkins says the U.S. saw more than 205,000 new cases — though those numbers may have been skewed by the Thanksgiving holiday when some local governments chose not to report new info.The mountainous increase in cases has resulted in a frightening increase in hospitalizations and hospital resource use. According to the COVID Tracking Project, a record 93,000 Americans across the country were hospitalized with COVID-19 as of Monday morning, an all-time record. On Oct. 31, that figure stood at just over 47,000. While hospitalizations have spiked across the country, 66% of those hospitalized are in the Midwest and South, meaning many rural hospitals in those regions are at capacity. With hospitals full, doctors and nurses are struggling to treat patients who are suffering from other emergency ailments.Sadly, the number of deaths from COVID-19 has steadily increased throughout the month. As of Monday morning, an average of 1,436 Americans had died of COVID-19 each day for the last week. On Oct. 31, that figure sat at just over 800. Therapeutics and new treatments for the virus have caused the death rate to fall since the springtime when nearly 2,500 Americans were dying every day. But despite the improvements in treatments, the U.S. continues to lose about as many Americans every two days that were lost in the Sept. 11, 2001 terror attacks.And while several companies have reported encouraging news regarding potential vaccines in recent weeks, health experts warn the pandemic will get much worse before they are widely available.Prior to Thanksgiving, Dr. Anthony Fauci — America's top infectious disease expert — warned that the holiday could cause the rate of transmission to rise exponentially, given that some celebrations included large indoor gatherings."The chances are that you will see a surge superimposed on a surge," Fauci said. 2450