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WELLINGTON, June 7 (Xinhua) -- Scientists in New Zealand have developed a new drug to fight previously untreatable hypoxic cancer tumors, which form in areas of the body starved of oxygen.The researchers at the Auckland University have entered an agreement for the clinical development of CEN-209, which was developed over 10 years of research, said a statement from the university Tuesday.CEN-209 was designed to enhance the effectiveness of radiotherapy and chemotherapy in solid hypoxic tumors, which were resistant to standard cancer therapies, said the statement. In lung cancer patients for example, about half of tumors had hypoxic regions.The new drug worked by damaging the DNA of hypoxic cancer cells, while leaving normal, healthy tissues alone.CEN-209 was designed and created by researchers at the university's Auckland Cancer Society Research Centre (ACSRC), using computer models of drug transport within tumors to accurately predict the anti-tumor activity of the drugs."Our computer models of drug transport developed in-house allowed the synthetic chemists to test their design theories and considerably shortened the discovery process," said Associate Professor Michael Hay, who led the ACSRC research chemists."CEN-209 improves markedly on previous agents in this class in terms of its ability to penetrate tumors, and this is reflected by its improved activity in the laboratory, when combined with long or short courses of radiotherapy," said researcher Professor Bill Wilson.Under the agreement between the university's Auckland UniServices Ltd. and California-based Centella Therapeutics, Inc., a subsidiary of Varian Medical Systems, Inc., Centella will have exclusive rights to CEN-209, which it will develop and trial with Cancer Research UK.The work on CEN-209 is the culmination of a program initiated with funding from the U.S. National Cancer Institute, and more recently from the Maurice Wilkins Centre for Biodiscovery. Ongoing preclinical research on CEN-209 and a backup compound was funded by grants from the Auckland Medical Research Foundation, Genesis Oncology Trust and Health Research Council of New Zealand, said the statement.
BEIJING, Sept. 26 (Xinhua) -- Nobel laureates on Monday cast doubt on a European experiment that purportedly demonstrated the ability of neutrinos to move faster than the speed of light.They made the remarks in Beijing prior to a forum for Nobel laureates."I'm willing to bet money that it's not correct," said Professor George Smoot III, winner of the 2006 Nobel Prize in Physics and a professor at University of California, Berkeley, referring to an experiment result claiming that particles apparently travel faster than light.The experiment reported an anomaly in the flight time of neutrinos, or electrically neutral subatomic particles, from the European Center for Nuclear Research (CERN) in Switzerland to a laboratory located 730 kilometers away in Italy.Particles were clocked transmitting at a speed of 300,006 kilometers per second, about 60 nanoseconds faster than the speed of light.Smoot said that the claims "did not make sense" and should be verified by other scientists first."There are many distortions in physics. You have to have a very high standard to see if something is truly correct," he said.The unverified findings were published on Sept. 22 in the scientific journal Nature. European researchers working in a team called OPERA (Oscillation Project with Emulsion-Racking Apparatus) projected masses of neutrinos from CERN and then collected the particles using a massive detector in Gran Sasso, south of Rome.Other scientists, as well as the OPERA team themselves, have voiced doubts regarding the experiment's results.The findings, CERN claims, could pose far-reaching potential consequences once verified.If correct, the results would bring Einstein's theory of special relativity into question. Under this theory, a physical object cannot travel faster than the speed of light in a vacuum."If really it is right, we have to rethink everything we know," said Chris Llewellyn Smith, former director of CERN.Smith claimed the unprecedented discovery was too exceptional to find proof."If somebody makes a very exceptional claim, then very exceptional proof would need to come from another experiment, saying the same thing. But we don't have the other thing," Smith said.Carlos Rubbia, a Nobel Laureate who won the prize for physics in 1984, is in charge of a team of more than 100 scientists at CERN."What it is pretending to find, in my view, is unbelievably surprising," Rubbia said."Frankly, I have the feeling that this is still a very experimental consideration," Rubbia said.He also believes that revealing the findings to the public was a mistake as it remained an experimental process and no conclusion could be drawn without the results of another experiment.Despite the possibility of verification, Einstein's special theory of relativity will remain valid."I will be very, very surprised that, at last, Einstein will not be the winner," Rubbia said.To achieve a breakthrough, Rubbia has urged for more joint cooperation on verifying the test results. International cooperation on this issue "is a must.""It requires coordination from all nations," said Rubbia.The 2011 Nobel Laureates Beijing Forum will be held from Sept. 28 to 30 under a theme of "innovation and development."
BEIJING, June 26 (Xinhua) -- A drama honoring an archivist who had devoted himself to the Chinese People's Liberation Army (PLA)'s archive work was staged Saturday evening in Beijing.The drama, "Sheng Ming Dang An," or "Archives of Life," tells the life story of Liu Yiquan who had worked as a file clerk and later a consultant at the PLA Archives for about 38 years.Liu had collected more than 830,000 pieces of military archives, which was regarded as a special contribution to the army. Li Changchun (L, front), a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, congratulates actors on the successful performance of drama "life archives" in Beijing, capital of China, June 25, 2011.Despite being diagnosed with terminal cancer in 2008, Liu continued to work hard. He died on Jan. 28, 2010, at the age of 59.Li Changchun, a Standing Committee member of the Political Bureau of the Communist Party of China (CPC) Central Committee, joined the audience of the drama on Saturday.Li later said the drama was touching and significant in reflecting the model role of CPC members ahead of the 90th founding anniversary of the CPC.Liu Yiquan was also honored by the U.S. military authorities for his role in helping identify some key documents that led to the repatriation of the remains of the United States personnel who disappeared during and after the Korea War (1950-1953).
coastline in the U.S. State of California sampled by the state water board harbored fish with mercury in such high concentrations that they shouldn't be eaten by young women and children, a newly released survey has found.Fourteen percent of locations had similarly elevated levels of PCBs, according to the survey published by The Los Angeles Times on Sunday.The most elevated concentrations of mercury and PCBs were found in San Francisco Bay and San Diego Bay, said the survey funded by the state water board.The findings, part of a two-year inquiry that is the largest statewide survey of contaminants in sport fish along the California coast, examined more than 2,000 fish from three dozen species gathered in 2009 from waters near Los Angeles, San Francisco and San Diego, the paper said.The survey highlights the health problem of lingering mercury, a poisonous metal that is found in fish globally, and of PCBs, toxic chemicals the United States banned in the 1970s, the report said.Both substances continue to pose a risk to people who eat fish caught along the California coast because they can lead to nervous system damage and developmental problems in children and can cause cancer, liver damage and reproductive harm, the report quoted researchers as saying."Unfortunately, we're not seeing many areas that are totally clean," said Jay Davis, a senior scientist for the San Francisco Estuary Institute and lead author of the study. But a catalog of where and in what fish the substances abound should help anglers make better choices, Davis said. "With good information, people can reduce their exposure significantly."Sharks had some of the highest levels of mercury because of their unusual tendency to accumulate contaminants in their flesh, while chub mackerel had the lowest levels of contamination, according to the survey.The survey results were used in part to help craft new fish consumption guidelines issued earlier this week for anglers in San Francisco Bay, the first update there by state health officials in 17 years. The advisory identifies shiner perch and other surf perches as unsafe to eat in any quantity and warns young women and children not to eat white sturgeon, striped bass and sharks caught in the bay, The Times said.The buildup of metals and other chemicals in fish is such a problem along the Southern California coast that health officials two years ago expanded the number of fish species on the "do not eat" list from one to five because of high levels of PCBs, mercury and the banned pesticide DDT, the report noted.