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SHENZHEN, June 4 (Xinhua) -- Chinese scientists who have fully sequenced the genome of the new E. Coli spreading through Europe said Saturday they found genes in the bacteria that gave it resistance to eight classes of antibiotics.Researchers with the Beijing Genomics Institute, the world's largest DNA sequencing center, have found genes in the newly identified 0104 strain of E. Coli bacteria that made it resistant to major classes of antibiotics including sulfonamide, cephalothin, penicillin and streptomycin.This helped explain why doctors in Europe had difficulties in fighting the bug that has killed 18 people and sickened nearly 2,000, BGI's major research arm in Shenzhen said on its website Saturday.This would help doctors choose right medicines for the treatment, it said.The researchers are developing a diagnostic kit which will be used to detect the bacteria and prevent the epidemic from spreading further.The Chinese researchers obtained DNA samples of the bacteria from collaborating scientists in Germany and fully sequenced its genome in three days this week.They announced on Thursday the E. Coli spreading through Europe was "a new strain of bacteria that is highly infectious and toxic".The 0104 strain of E. Coli was not previously involved in any E. Coli outbreaks. However, it has 93 percent sequence similarity with the EAEC 55989 E. Coli strain which was isolated in the Central African Republic and known to cause seriously diarrhea, BGI said.The source of the outbreak is unknown, but scientists say it is highly likely to have originated in contaminated vegetables or salad in Germany.

BEIJING, Aug. 18 (Xinhua) -- A controlled trial has found that Chinese herbal medicine decoction maxingshigan-yinqiaosan has a similar efficacy to oseltamivir in reducing time to fever resolution in people suffering mild H1N1 influenza virus infections.Carried out by a group of Chinese researchers, headed by Prof. Wang Chen with Beijing Chao-Yang Hospital under the Capital Medical University, the study was published by the famous internal medicine journal Ann Intern Med on Tuesday.Participants of the trial were 410 young adults aged 15 to 59 years with laboratory-confirmed H1N1 influenza.The researchers concluded that both active intervention, alone and in combination, were effective in reducing time to fever resolution in young adults with H1N1 flu, and therefore suggest that maxingshigan-yinqiaosan may be an alternative to oseltamivir.

WASHINGTON, July 20 (Xinhua) -- The loss of a protein that coats sperm may explain a significant proportion of infertility in men worldwide, according to a study by an international team of researchers led by University of California Davis.A paper describing the work was published Wednesday in the journal Science Translational Medicine. The research could open up new ways to screen and treat couples for infertility.The gene DEFB126 encodes a protein called Beta Defensin 126, which coats the surface of sperm and helps it penetrate cervical mucus in the female. A survey of samples from the U.S., Britain and China showed that as many as a quarter of men worldwide carry two copies of the defective gene.In the new study, researchers found that men with a muted DEFB126 lack Beta Defensin 126, making it much more difficult for sperm to swim through the mucus and eventually join with an egg.Examining 500 newly married Chinese couples, researchers found that the lack of Beta Defensin 126 in men with the DEFB126 mutation lowered fertility (even among men that did not display other deficiencies usually associated with infertility, like inadequate semen volume and low sperm motility). Wives of men with the Beta Defensin 126 variant were significantly less likely to become pregnant than were other couples, and 30 percent less likely to have a birth.This genetic variation in DEFB126 likely accounts for many unexplained cases of infertility, researchers say. They hope next to work with a major infertility program in the U.S. to further explore the role of the mutation.

SAN FRANCISCO, Aug. 17 (Xinhua) -- Microsoft's cloud-based software Microsoft Office 365 on Wednesday experienced its first major outage since its introduction in late June."At approximately 11:30 a.m. PDT, Microsoft became aware of a networking issue affecting customers of some Microsoft services hosted out of one of our North American data centers," said Steven Gerri, general manager for Microsoft Global Foundation Services, in a statement"We apologize for the inconvenience that Office 365 outage has caused today. We are working on resolving the issue," the software giant said via Twitter.Outages were reported in Chicago, Denver and New York City among other locations. According to tweets from affected users, they were unable to access their email and managers were unable to manage accounts.The outage lasted approximately five hours and services have been restored for the moment.According to Microsoft service-level agreement, Microsoft guarantees a 99.9 percent level of uptime. If it fails to reach 99.9 percent uptime, users are eligible for 25 percent service credit.As more industry giants try to entice users to move to the "cloud," a term refers to the management and provision of applications and data over the Internet, the downtime again reminds cloud computing users that they must prepare to deal with outages and rethink their dependency on the service, analysts said.Amazon has suffered two major cloud outages earlier this month and back in April, impacting some of its high-profile users like movie streaming service Netflix and location-based social networking Foursquare.Analysts recommend cloud users to store data with multiple service providers to minimize the risk and limit their dependency on cloud services for business-critical processes.Available in 40 countries and regions since June 28, Office 365, which Microsoft CEO Steve Ballmer said is "where Microsoft office meets the cloud," combines Microsoft Office, SharePoint Online, Exchange Online and Lync Online into a single cloud-based package for business users.

BEIJING, August 1 (Xinhuanet) -- U.S. researchers have discovered a genetic mutation unique to African Americans that links to heighten their asthma risk, according to reports published on Sunday in the journal Nature Genetics.Researchers of University of Chicago found a gene, PYHIN1, and its variations may account for asthma risk in people of African descent. In their study, they examined data from nine previous genome-wide association studies, totaling more than 2 million single nucleotide polymorphisms in 3,246 asthma patients and 3,385 control patient, 1,702 patient-parent groupings, 355 family-based cases, and 468 family-based controls.In the study, the researchers found that between 26 percent and 29 percent of people of African-descent carried at least one copy of the gene.  In particular, one polymorphism of the gene was 34 percent more likely found in African-American and Afro-Caribbean people with asthma.  More interestingly, this variant of the gene is rarely found in Caucasian people and in Latino population, it was found in less than 5 percent.This new variant is part of a family of genes linked with the body's response to viral infections. It is thought to be involved in interferon signaling, which could influence the occurrence of asthma.The team stressed that each gene variant on its own plays only a small role in increasing asthma risk, but that risk could be multiplied when combined with other risk genes and with environmental factors.