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Opioid drugs -- including both legally prescribed painkillers such as oxycodone and hydrocodone, as well as illegal drugs such as heroin or illicit fentanyl -- are not only killing Americans, they are shortening their overall life spans. Opioids take about 2.5 months off our lives, according to a new analysis published in the medical journal JAMA.In 2015, American life expectancy dropped for the first time since 1993. Public health officials have hypothesized that opioids reduced life expectancy for non-Hispanic white people in the United States from 2000 to 2014. Researchers have now quantified how much opioids are shortening US life spans.The researchers noted that the number of opioid overdose deaths are probably underestimated because of gaps in how death certificates are completed.From 2000 to 2015, death rates due to heart disease, diabetes and other key causes declined, adding 2.25 years to US life expectancy. But increases in deaths from Alzheimer's disease, suicide and other causes offset some of those gains. On average, Americans can now expect to live 78.8 years, according to data from 2015, the most recent data available. That's a statistically significant drop of 0.1 year, about a month, from the previous year.Women can still expect to live longer than men -- 81.2 years vs. 76.3 years -- but both of those estimates were lower in 2015 than they were in 2014.Life expectancy at age 65 remained the same in 2015. Once you've reached that age, you can expect to live another 19.4 years. Again, women fare slightly better: 20.6 years vs. 18 years for men. 1603

One person was killed Tuesday and three others injured in an explosion in a medical building in Aliso Viejo, California, authorities said.The explosion blew out walls and windows, heavily damaging the first floor corner of the two-story building and hurling debris outside, said Capt. Tony Bommarito, a spokesman for the Orange County Fire Authority.Authorities have not found any explosive devices in the area, and Bommarito said there didn't appear to be a gas leak.FBI spokesman Mike Gifford said there was no initial indication of terrorism."We do not know at this time whether this was an intentional detonation of a device or whether it was an accident," said Orange County Sheriff's Department Commander Dave Sawyer, who added that officials are not ruling out anything.Sawyer said it appears the blast was concentrated in a suite on the first floor of the office building.The victim, who was killed, and the three survivors were likely close to the explosion, Sawyer said.He said investigators are interviewing the three survivors.Two survivors had critical injuries "that were consistent with an explosion, but not necessarily consistent with a bomb," said Carrie Braun, a spokeswoman for the Orange County Sheriff's Department.The sheriff's department is partnering with the FBI, the Department of Homeland Security, and the Bureau of Alcohol, Tobacco, Firearms and Explosives, who will assist the investigation, Sawyer said.Bommarito said firefighters responded to a call of an explosion shortly after 1 p.m. local time. About 10 engines and 70 firefighters were dispatched.There is a daycare and preschool nearby, but Orange County Fire Authority Chief Brian Fennessy said no children were injured and all are accounted for.Aliso Viejo is about 7 miles northeast of Laguna Beach. 1799

On Monday morning, Pfizer announced that so far in Phase 3 trials, its COVID-19 vaccine candidate has been 90% effective in promoting protection against the virus. And while the announcement has many Americans seeing the light at the end of the tunnel, the pandemic is still far from over.Pfizer's announcement on Monday is an encouraging sign, as it means that the company is on track to file for Emergency Use Authorization for the vaccine in the coming weeks. It also keeps the U.S. on a timeline to have at least one vaccine approved and available for distribution by the end of 2021.But Monday's announcement does not mean a vaccine is imminent. Pfizer is currently mass-manufacturing its vaccine candidate in the event it does receive Emergency Use Authorization from the FDA, and hopes to have 100 million doses of the vaccine ready to ship by year's end. But even if Pfizer is able to fulfill that ambitious order by Dec. 31, it would only be able to vaccinate about one-third of everyone in the county.Once the initial vaccine order has been completed, it will need to be rationed for those who need it most — likely health care workers, essential employees and people in high-risk populations. While it is unclear who exactly will be eligible to receive the vaccine first, the Department of Health and Human Services (HHS) says the early distribution of a COVID-19 vaccine will be "constrained tightly" and will be "highly targeted" to "achieve coverage in priority populations."Eventually, the U.S. hopes to grant emergency use authorization to several vaccine candidates — many of which are currently in production on orders from the U.S. government. HHS hopes that by the middle of next year, several vaccines will be approved and widely available. But at that point, officials will run into a second major hurdle — vaccine skepticism.Skepticism about vaccines has been on the rise in recent years, fueled in part by the spread of misinformation online. In particular, baseless conspiracies linking vaccines to autism have spread on social media, eroding public confidence in medicine. In addition, polarized politics in the U.S. have led to speculation that government leaders will approve an unsafe or ineffective vaccine for political purposes.Vaccines are only effective if enough members of the public become inoculated against a virus — if a virus has nowhere to spread, it will eventually die out. But Gallup polling released in October shows that just 50% of Americans say they would receive a COVID-19 vaccine if it had been approved by the FDA and available at no cost — far below the threshold for herd immunity, according to many health experts.The Gallup polling is consistent with AP polling from earlier this year that also only found 50% willingness to take a COVID-19 vaccine.All the while, the final push for a COVID-19 vaccine will be occurring during what members of the White House coronavirus task force warn will be the most concerning and deadly period of the pandemic. The virus is currently spreading in the U.S. faster than it has at any other point during the pandemic, just as Americans are moving social gatherings indoors where the virus is more likely to spread.To be clear, health officials' efforts to develop a safe and effective COVID-19 is a momentous and historic achievement — approving a vaccine for emergency use by the end of the year would shatter all previous records for vaccine development. But while there may be light at the end of the tunnel, it may take several months — or years — to reach the end of the pandemic. 3586

One hundred and seventy-five former US officials spanning service across intelligence agencies, the State Department, the National Security Council and the Department of Defense added their names on Monday to a list of intelligence officials denouncing President Donald Trump's decision to revoke former CIA Director John Brennan's security clearance."All of us believe it is critical to protect classified information from unauthorized disclosure. But we believe equally strongly that former government officials have the right to express their unclassified views on what they see as critical national security issues without fear of being punished for doing so," the letter states."Our signatures below do not necessarily mean that we concur with the opinions expressed by former CIA Director Brennan or the way in which he expressed them," the group statement added. "What they do represent, however, is our firm belief that the country will be weakened if there is a political litmus test applied before seasoned experts are allowed to share their views." 1067

OCEANSIDE, Calif. (KGTV) - Woven into the fabric of Oceanside is a thriving military community."They're like family to us, they participate in our events, they patronize our business, they attend our churches, and many live in our community," says Scott Ashton, CEO of the Oceanside Chamber of Commerce.Camp Pendleton employs roughly 49,000 military personnel, 40,000 of which are Marines. But the facility sees an average daytime population of 70,000 employees, military family members, and visitors, according to SANDAG.In the region as a whole, the San Diego Military Advisory Council (SDMAC) reported that in 2019, the military was responsible for over billion in direct spending, which resulted in a Gross Regional Product of over billion and over 354,000 jobs. One place you're almost always guaranteed to find a Marine is Knuckleheads Barbershop."In Oceanside, our bread and butter is servicing the Marine Corps, servicing the military," said Patrick Llamas, a Marine Corps veteran and barber at Knuckleheads. Owner Sara Llanes estimates about 80 percent of their business relies on the military. "It's fun to work with the military, I think they're great, and they're great customers," said Llanes. Gunnery Sgt. Lukas Atwell is stationed at Camp Pendleton. "The little conveniences that are available in life, Farmers Markets, entertainment, all of the different things you can do in Southern California, they're outside the gates, and we definitely need those services," said Atwell. The city also has many veteran-owned businesses, over 100, according to the American Legion."The military is just an incredibly important part of our community here in Oceanside," said Ashton. 1702