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Researchers published what they say is the first case of a living person diagnosed with the degenerative brain disease chronic traumatic encephalopathy or CTE.While unnamed in the study, lead author Dr. Bennet Omalu confirmed to CNN that the subject of the case was former NFL player Fred McNeill -- who died in 2015.Omalu is credited with first discovering CTE in professional football players. Until now, the only way to diagnose the disease is with a brain exam after death.The diagnosis was first made using an experimental brain scan that can trace a signature protein of CTE called tau. The authors then confirmed the diagnosis with an autopsy. The case study was published in the journal Neurosurgery this week.'It looked like just depression'Omalu first presented these findings exclusively to CNN's chief medical correspondent, Dr. Sanjay Gupta, in 2016. McNeill's wife, Tia, and his two sons, Gavin and Fred Jr., told Gupta then that they saw Fred transform from a fun loving family man at the center of their lives into a man who was dealing with symptoms of memory loss, anger and depression that tore their family apart."There are some times where the father is the stronghold in the family, or the anchor. If you lose that, everything kind of falls apart. That's kind of what happened for us. It looked like financial issues at first; it looked like marital issues, and they separated; then it looked like just depression," Gavin told Gupta.CTE is known for plaguing people with Alzheimer's like symptoms such as memory loss, rage, mood swings, and in some cases, suicidal ideation.Severity of the disease is categorized into four stages, with stage 4 being the most severe. While researchers don't know exactly why certain people develop the disease and others don't, they believe that it results from repeated blows to the head that trigger a build up of tau proteins in the brain.CTE has been called football's "concussion crisis," however experts point out that CTE can develop from any repeated head injury. According to the Boston University CTE Center, "this trauma includes both concussions that cause symptoms and subconcussive hits to the head that cause no symptoms." These subconcussive hits can include the repeated trauma the brain experiences from constant plays, hitting the turf, and tackling. Wrestlers, boxers, and military troops have also been diagnosed with the disease.Seeing CTEWhile McNeill is the first case to be confirmed with an autopsy, the experimental technology has been used on at least a dozen other former NFL players, including Pro Football Hall of Famer, Dallas Cowboy Tony Dorsett. Omalu helped develop and is invested in the diagnostic exam, which uses a radioactive "tracer" called FDDNP to bind to tau proteins in the brain. The tau proteins can then be seen on a PET scan of the brain.Critics have said the protein also can highlight another protein called amyloid, which may be indicative of Alzheimer's or other forms of dementia. But Omalu noted that in CTE, tau makes distinctive patterns in the brain. It has a "specific topographic signature," he said, and that pattern can be detected in imaging.Omalu said he and his team are currently raising money to start a phase 3 clinical trial to further test the technology and replicate what they have seen in McNeill. He anticipates that once funds are raised, it will take another two to three years for the trial and then another year, at least, for approval from the US Food and Drug Administration. When asked, how soon a commercial test could be available, Omalu predicted it could be as soon as a few years. "We are looking at less than five years," he said.  3711

Record unemployment rocked the real estate market. Now, interest rates are at record lows, giving many people a new way to save money by refinancing their current mortgage.Matthew Garcia, a senior loan officer with Supreme Lending, says now is a good time to refinance your home. "Absolutely. I mean, you’re looking at interest rates being at the most historic rates they’ve ever been. Rates have been in the 3% ranges before but now you’re seeing 30-year loans getting into the upper twos and middle twos, which is completely insane," said Garcia.Garcia says the industry is going through a refinancing boom that it hasn't seen since a few years after the Great Recession. Refinancing your mortgage, or essentially restructuring your current home loan under a new, lower interest rate, can be done for a couple different reasons."There’s two main types of refinancing you can do. There’s what’s called rate term refinance which means I’m simply refinancing the balance from any closing costs I might have and dropping the interest rates. That’s what called Rate Term, taking no additional cash out. Then there’s also cash out. Cash out refinances tend to be a bit more expensive. When I say more expensive, I mean the rates are slightly higher, more expensive in cost structure," said Garcia.For cash out refinancing, home owners who have likely owned their property for at least four or five years, are refinancing to take the extra cash from the increased equity in the home, and invest it in renovations or elsewhere."Where people can get into more danger is, they're taking out money because they want to go out and invest in other investment properties, go use that money to go out and buy other homes, speculate. That’s where it gets a bit dangerous. A lot of folks start watching their HGTV and think they're the expert and they're going to tap into this equity and go and do these things. There’s a lot more to it," said Garcia.Garcia says the last thing people want is to end up with two failed mortgages. He says the best reasons to refinance is debt consolidation or if it will save money in the long run.Josh Stech, CEO and co-founder of Sundae, a company that helps people with homes in bad condition get their properties sold, also says it's a good time to refinance because of how great the real estate market was doing before the COVID-19 pandemic."Rates are really low but also equity in homes was really high. We hit historic highs heading into the pandemic in terms of the amount of equity that homeowners have in their homes. Basically, the value versus the mortgage that they owe," said Stech. As for how long interest rates will last, Federal Reserve Chairman Jerome Powell has said they could be around for years. Sheck says, there's a chance interest rates could go even lower but there's already so much demand to refinance and banks can only process so many."I think as the fed is targeting a longer term near-zero interest rate environment, I think actually if you maybe wait a little bit you might play the game and win and get a lower interest rate because of the supply and demand I mentioned. I think it's a great time. It's hard to argue with record lows you haven't seen since 1971," said Stech.Experts recommend people who are considering refinancing to talk to a loan officer or financial advisor to make the best decision for their situation. But, if it's something they're interested in doing, to look into it while the rates are as low as they are. 3495

President Donald Trump says his campaign will join an improbable case before the Supreme Court challenging election results in Pennsylvania and other states that he lost.That word comes as he tries to look past the justices’ rejection of a last-gasp bid to reverse Pennsylvania’s certification of Democrat Joe Biden’s victory. The high court has asked for responses by Thursday.The suit from the Texas attorney general, Republican Ken Paxton, demands that the 62 total Electoral College votes in Georgia, Michigan, Pennsylvania, and Wisconsin be invalidated. Legal experts dismiss Paxton’s filing as the latest and perhaps longest legal shot since Election Day, and officials in the four states are sharply critical of Paxton.On Thursday, Trump’s official schedule includes a lunch with state attorneys general. Seventeen Republican attorneys general have joined the Paxton/Trump suit.The lawsuit is a last-ditched effort to overthrow the results of the election, which saw more vote cast for Biden than any other candidate in American history.Trump and his legal team has continued to allege that Biden fraudulently won the election. So far, Trump’s legal team has not been able to substantiate any fraud allegations in court, prompting one federal judge appointed by Trump to write in an opinion, “Charges of unfairness are serious. But calling an election unfair does not make it so. Charges require specific allegations and then proof. We have neither here,” 3rd Circuit Judge Stephanos Bibas wrote. Bibas was appointed by Trump to the federal bench in 2017.Last month, a joint statement released by federal and state officials described the presidential election as the “most secure in American history.”The letter was signed by leaders of the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency, the U.S. Election Assistance Commission and the National Association of State Election Directors, among others. The Cybersecurity and Infrastructure Security Agency was established two years ago as a branch of Homeland Security during the Trump administration.In bold, the authors of the statement wrote, “There is no evidence that any voting system deleted or lost votes, changed votes, or was in any way compromised.” This statement matches those from secretaries of state and boards of election throughout the US.In response to the letter, Trump fired US election security head Chris Krebs. 2434

QUEEN CREEK, Ariz. — Conversations have been forced to change in children's classrooms. Many adults remember simply learning about a basic fire drill or what to do in a lockdown.But today, many teachers are having to teach kids what to do in case of an active shooter. Another safety net that is being used in places around Arizona, including Queen Creek Unified School District, is a donated, repurposed tool from the Queen Creek Fire and Medical Department: fire hoses. "They're cut into a certain segment. They are perfect to go over the hinges of our doors and that just adds this extra layer of security to our classroom," said Newell Barney Middle School science teacher Tammi Brewster. Brewster explained how the recycled and donated fire hoses from the fire department become a deterrent for any "bad guys" trying to get into a classroom and are now a part of their lockdown procedure called ALICE. ALICE stands for alert, lockdown, inform, counter and evacuate. Brewster said that the fire hose is part of a larger conversation with students regarding school shootings. It helps explain the procedure for active shooter or lockdown drills in a way that does not scare them, but empowers them. "It gives them a relief that, 'OK, all of this is going on in the news, in our society and I have choices I can make. I don't have to sit in a corner and be scared,' '' Brewster said. "The schools have their processes and their programs in place for a lockdown," said Queen Creek Fire Chief Vance Gray. "What we wanted to do was just assist by adding another layer of protection for the teachers and the students and the schools." Gray said his two children went to one of the schools where he has donated these fire hoses.While it is a piece of equipment he never hoped he would have to pass out, he knows taking action is the only thing to do. "If you can't change the way things are and make them exactly how you want them to be, then the best thing you can do is prepare," Gray said. He said they will continue donating their fire hoses whenever they go out of service.  2169

Reports compiled by Zac Self.TOKYO (KGTV) -- Ahead of a 13-day trip through Asia, President Donald Trump touched down in Japan late Saturday night.Following his arrival, the President spoke at the joint U.S.-Japanese military base, reports CNN."Our brave warriors are the last bulwark against threats to the dreams of people in America and Japan and all across the world," Trump said. "You are the greatest hope for people who desire to live in freedom and harmony and you are the greatest threat to tyrants and dictators who seek to prey on the innocent."President Trump’s tour through Asia will take him to South Korea, China, Vietnam and the Philippines.Much of the President’s trip will focus on rallying other countries in the region to step up efforts to pressure North Korea into abandoning nuclear and ballistic missile programs. 845

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