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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

ISTANBUL, May 3 (Xinhua) -- The world's water consumption will increase by 40 percent over the next two decades and efforts to meet this demand must increase radically, the secretary-general of the 5th World Water Forum said here on Tuesday.Oktay Tabasaran said in his opening speech at the World Water Forum that "water consumption will increase by 40 percent in the coming 20 years, reaching 6.9 trillion cubic meters per year ( compared with the 4.5 trillion used currently), and an amount of 200 billion U.S. dollars must be spent annually in order to afford this."He said such figures indicated the urgent need for countries to engage in efficient cooperation with each other to address water- related issues.Some 50 out of the world's 188 countries have serious concerns in providing drinking and irrigation water, due to careless and inefficient use of water, according to Ismail Ugur, the general director of Turkey's State Waterworks Authority."If we fail to come up with solutions, starting from 2015 there will be droughts (in many parts of the world) and people will start suffering from diseases caused by lack of water, as of 2025, " Ugur said.Ekmeleddin Ihsanoglu, head of the Organization of the Islamic Conference (OIC), said that ensuring reliable access to water is crucial to promoting peace and security in the Middle East, where many countries are facing dramatic declines in available water."In some regions of the Muslim world, water availability is predicted to be cut in half by 2050, even without taking into consideration the effects of climate change," he said in his opening speech.The OIC chief called for increased cooperation among member states and countries outside the region, announcing the group's progress in preparing its own "Water Vision" document and forming an OIC Water Council to address water-related concerns."In its first phase, the Water Vision will outline a framework of cooperation on water-related issues in terms of water-sharing experience, capacity development, technology transfer, water governance and institutional reforms," Ihsanoglu said.He cited the Friendship Dam, to be constructed on the Orontes River at the Turkish-Syrian border, as an excellent example of cooperation and peace among neighboring countries in the field of water.Charity Ngilu, minister for water and irrigation of Kenya, stressed the importance of water in promoting peace, especially in regions where water scarcity prevails."There have been many conflicts caused by water scarcity not only among African countries, but even within regions of the same country," She said, adding Kenya would ask Turkey for cooperation and assistance in water management and other related issues.

JOHANNESBURG, March 8 (Xinhua) -- In order to combat piracy and to improve maritime safety, South African authorities have begun using a sophisticated navigation satellite system, it was announced on Tuesday.Piracy, especially by Somalis, has been increasing along Africa east coast in recent years. The South African Press Association (SAPA) reported on Tuesday that Karl Otto, head of the South African Maritime Safety Authority (SAMSA) announced the surveillance tool at a conference in Durban.Called Long Range Identification and Tracking (LRIT), the system monitors and tracks vessels in waters south of the equator.Otto said the introduction of the LRIT followed concerns over the safety of seafarers, the safety standards of ships within South African waters.Otto said there were high levels of cargo at risk, such as fuels and oils.He said reasons for installing the system included the number of shipwrecks along the South African coast, and the threat of pollution of the marine environment by ships."It also serves as a mechanism to prevent piracy."Otto said the satellite system has the capacity to identify and track vessels up to 1,000 nautical miles (1,850 km) from the South African coastline as well as South African-flagged vessels anywhere in the world."This is a revolutionary development in the security of our seas," he said.SAMSA was determined to protect South Africa's seafarers, its coastline and the marine environment, Otto said.

BEIJING, March 10 (Xinhuanet) -- Cigarette displays in shops will be banned and tobacco companies may also be forced to make their products in plain wrappers in an attempt to stop people from smoking, announced the UK government Thursday.The prominent displays and attractive packaging of tobacco have long provided shopkeepers with stable income, keeping addicts hooked and quitters tempted.However, the government's move that will begin as early as spring next year will keep cigarettes hidden away and make it just a tad more difficult for smokers to find their fix."Nearly all adult smokers started smoking before they turned 18 and every year, over 300,000 children under 16 try smoking," said Chief Medical Officer Sally Davies."Smoking is undeniably one of the biggest and most stubborn challenges in public health. Over eight million people in England still smoke and it causes more than 80,000 deaths each year," Health Secretary Andrew Lansley said in his statement on the new law.Now, this move has drawn predictable responses from both sides of the tobacco wars, with health groups cheering and retailers grumbling.The British Medical Association said it was "very pleased" with the announcement, citing research which it said showed that a display ban would play "a key role in discouraging children from smoking and also help smokers quit."On the other hand, industry groups and independent retailers complained it would burden them with the cost of refitting their stores and reduce their already narrow profit margins.And according to media interviews, many people kept skeptical about the real impact the move would have, especially on young smokers.