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SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) — Border agents arrested 15 people over Presidents’ Day weekend during a smuggling event in Mission Bay.U.S. Border Patrol agents caught the smuggling incident in action on Saturday at about 2 p.m. at a Ski Beach launch ramp. As agents got closer, they say they noticed a large group of people quickly exiting the boat and heading for three vehicles.Agents stopped the individuals from getting away and questioned all 15 people involved in the incident.Agents say six people in the group were suspected of human smuggling and arrested. Five of them are U.S. citizens, including four men ranging from 20 to 30 years old and one 25-year-old woman, according to border officials.The nine other people arrested were male Mexican nationals ranging from 27 to 41 years old who admitted to being illegally present.U.S. Border Patrol seized the boat and three vehicles at the scene. 899

SAN DIEGO (KGTV) - As re-closures loom in San Diego County, anxiety is building.Licensed Psychologist Dr. Michelle Carcel said she and other colleagues noticed higher anxiety and depression among those who are isolating."Then there's the reality of, 'okay the cases are surging and things are starting to shut down again,' so there is that isolation anxiety," Dr. Carcel said, explaining we are pack animals and can feel in danger if alone for extended periods of time.She said on the flip side, some are feeling a sense of comfort in a new routine that's taking root, as we enter the fourth month of the pandemic.The possibility of all indoor activities getting shut down Monday threatens that new normal many have created.Dr. Carcel said there are still options to get together, "we can get creative with this. There's hiking outdoors, there's biking we can do. All of that within the context of social distancing." Another anxiety is the job market. While unemployment is down for the sixth straight week, SANDAG said 200,000 San Diegans are still out of work.Dr. Carcel acknowledges these times are hard but it is important to have hope. "We're just constantly thinking in absolutes, 'Oh it will never reopen. It will never get better,' that is a very bad way to think, we actually want to think about this being temporary because it will be."She impressed the importance of vaccines being developed at light speed and suggested those who are anxious about the re-closures should create a game plan."We talk about a cope ahead plan on specific things we can do in lieu of things we are currently enjoying if things shut down again so that we're not disappointed," Dr. Carcel said.She reminded us this is temporary, and we will make it through. 1755

SAN DIEGO (KGTV) - County animal shelters are helping San Diegans "fall in love" for free this season.San Diego County Animal Services (SDDAC) will waive adoption fees for cats at their three shelters this weekend, Friday, Sept. 22 through Sunday, Sept. 24, as part of their "Fall in Love" event.RELATED: Adoption fees lowered as San Diego shelter makes more room for hurricane-impacted animalsCats have been spayed or neutered, have their current vaccinations and flea control, are microchipped, and come with a free veterinary exam in the first 10 days, according to SDDAC.The county's three shelters are open from 9:30 a.m. to 5:30 p.m. Tuesday to Sunday; Adoptions close at 4:30 p.m.RELATED: 'Hurricane Harvey' dogs flown to San Diego from Louisiana up for adoptionAnyone can stop in prior to the promotion to check out cats in person or visit animals service's website to see available cats.The county's three shelters are located at: 967

SAN DIEGO (KGTV) -- Authorities are investigating after a body was found floating in the ocean off the coast of San Diego Monday afternoon. According to the U.S. Coast Guard, the body was discovered in the water approximately five miles off the coast of Mission Bay around noon. The body was found floating in the water with a life jacket nearby by a good Samaritan, the Coast Guard says. A second vest was also located in the water. RELATED: Body discovered at Sunset Cliffs is that of missing manThe Coast Guard launched a search by air and sea but didn't located a boat or any other victims. The search was suspended around 5:30 p.m. Monday. The crew took the body to shore, where it was transferred onto a police dock on Shelter Island just before 3 p.m. 767

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