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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — Mayor Kevin Faulconer and Jewish leaders celebrated the second night of Hanukkah Monday, lighting the second candle of a massive Menorah outside City Hall.As the second night of the Jewish Festival of Lights got underway, Rabbi Zalman Carlebach said it was important for leaders to show their support and celebrate in light of recent anti-Semetic incidents around the U.S. "In light of the current events that are happening around the country, this world could use some more light. America could use some more light," said Rabbi Carlebach.San Diego has numerous Menorah lighting events planned as well as other celebrations throughout the county as Hanukkah continues — running through Dec. 10. Check out where to celebrate in San Diego here. 769

SAN DIEGO (KGTV) — Military families say the squalid living conditions detailed in a new report by the Military Family Advisory Network released Wednesday don't fully portray their struggle.In Murphy Canyon, the issues range from mice, to dry rot to rust. Shelby Stevens' husband is in the Navy, and they've been stationed in San Diego for three years. On the porch she pointed out what looked like half painted pergolas and said they were full of dry rot. Inside there is no microwave, and the kitchen was much the same as it was originally in the 1990's. "We've got ant problems, roaches, mice," Stevens showed 10News her shed in the back yard. Inside there's half a dozen mice traps, with little black dots covering the floor. Stevens says those are mice droppings.On her phone, an image of a dead mouse, she said her dog killed. These issues echoed throughout the military community.A woman who didn't wish to be identified, for fear of retaliation, said her closet door had loose rusted screws she had to keep out of her toddlers' reach. She said the repair work on a clogged toilet was shoddy, saying the men left mold, and poop around the base of the toilet.The new report by the Military Family Advisory Network breaks down the problems renters face by base. For San Diego military families, the top two issues are maintenance and mold."We absolutely know that the nearly 17,000 who responded to our questionnaire, this is their reality," Shannon Razsadin, Executive Director of MFAN, said.The survey went out last January and ran for a week. Razsadin hopes the report gives military families a tool to create change.The military moms who spoke with 10News say it's not a complete picture of what they're dealing with. Stevens said 17,000 people across the country is a very small part of the military community as a whole. She said in the last several months their service has declined."We've had no shows from maintenance men, we've had no shows from contractors who are scheduled to come out to my house, no show, no call. The office hasn't been in contact with any of us," she says.Her sense of despair growing, "these are the kinds of conditions we're living in," she said tearing up.The women said they pay more than ,000 a month and say the high cost of living is what keeps them in the military housing.10News reached out to Lincoln MIlitary Housing and recieved a comment Thursday morning: 2416

SAN DIEGO (KGTV) — Like Saturday, several cities around the county saw temperatures hit record highs as temperatures baked the county over the holiday weekend.Sweltering heat continued across the county on Sunday, prompting residents to flee for the coast only to be met by more high temps.According to the National Weather Service, several cities saw daily record highs for Sept. 6, with Escondido hitting an all-time high of 115 degrees:San Diego: 100° (old record: 97° in 2011)Oceanside: 85° (old record: 83° in 2004)Vista: 107° (old record: 102° in 2004)Chula Vista: 102° (old record: 97° in 2011)Escondido: 115° (old record: 104° in 1955) — an all-time recordRamona: 112° (old record: 102° in 1983)Palomar Mountain: 98° (old record: 94° in 1955)Campo: 110° (old record: 104° in 1955)Borrego: 117° (old record: 115° in 1989)Saturday, Alpine and El Cajon set all-time highs at 113 and 114 degrees, respectively.Monday, a slight heat reprieve with come to parts of the county. Monday's highs are forecasted for the coast at 80-91°, for the inland areas at 93-99°, in the mountains at 91-103°, and for the deserts at 113-119°. 1135

SAN DIEGO (KGTV) - It seemed to be an instant match for actress Kaley Cuoco.The "Big Bang Theory" star cried tears of joy when she found "the ones" in two pet rabbits adopted from San Diego County's Gaines Street animal shelter earlier this week.In a video posted to Instagram by Cuoco's fiancé, North San Diego County resident Karl Cook, Cuoco is seen with one of her new pets in hand belated with the new family members. 435