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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).

WASHINGTON, June 21 (Xinhua) -- A new study from Harvard School of Public Health (HSPH) and University of California, San Francisco, researchers suggests that men with prostate cancer who smoke increase their risk of prostate cancer recurrence and of dying from the disease. The study will be published Wednesday in the Journal of the American Medical Association."In our study, we found similar results for both prostate cancer recurrence and prostate cancer mortality," said Stacey Kenfield, lead author and a research associate in the HSPH Department of Epidemiology. "These data taken together provide further support that smoking may increase risk of prostate cancer progression."Kenfield and her colleagues conducted a prospective observational study of 5,366 men diagnosed with prostate cancer between 1986 and 2006 in the Health Professionals Follow-Up Study. The researchers documented 1,630 deaths, 524 (32 percent) due to prostate cancer, 416 (26 percent) due to cardiovascular disease, and 878 prostate cancer recurrences.The researchers found that men with prostate cancer who were current smokers had a 61 percent increased risk of dying from prostate cancer, and a 61 percent higher risk of recurrence compared with men who never smoked. Smoking was associated with a more aggressive disease at diagnosis, defined as a higher clinical stage or Gleason grade (a measure of prostate cancer severity). However, among men with non-metastatic disease at diagnosis, current smokers had an 80 percent increased risk of dying from prostate cancer.Compared with current smokers, men with prostate cancer who had quit smoking for 10 or more years, or who had quit for less than 10 years but smoked less than 20 pack-years before diagnosis, had prostate cancer mortality risk similar to men who had never smoked. Men who had quit smoking for less than 10 years and had smoked 20 or more pack-years had risks similar to current smokers."These data are exciting because there are few known ways for a man to reduce his risk of dying from prostate cancer," said senior author Edward Giovannucci, professor of nutrition and epidemiology at HSPH. "For smokers, quitting can impact their risk of dying from prostate cancer. This is another reason to not smoke."Prostate cancer is the most frequently diagnosed form of cancer diagnosed in the United States and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than two million men in the U.S. and 16 million men worldwide are prostate cancer survivors.

HOHHOT, Aug. 27 (Xinhua) -- A 5,000-year old rock carving in north China's Inner Mongolia Autonomous Region depicts a falling meteor, said archaeologists on Saturday.A rock on the side of Dahei Mountain in the city of Chifeng has images of people, domed houses and a fire ball with a long tail falling from the sky engraved on it, said Wu Jiacai, head of the Inner Mongolia rock paintings protection association."I believe it shows prehistoric people returning at dusk from a hunting trip to their domed houses, as a meteor falls from the sky," Wu shared his findings at the 6th Hongshan Cultural Forum that runs from August 25 to 27.He added that in the same location several years ago, another set of carvings were found showing people fleeing, snakes slithering and birds flying away, which might be what happened after the meteor hit the earth.The area has about 1000 carvings all believed to be made by the Neolithic Hongshan people, Wu said."The pictures can shed some light on the disappearance of the Hongshan culture, which was quite developed," Wu said.

UNITED NATIONS, Sept. 19 (Xinhua) -- As the UN on Monday pursued the world's top killer -- non-communicable diseases (NCDs) -- a leading doctor from the World Health Organization (WHO) called for preventative measures on such chronic diseases to be placed higher on the international agenda."It's not a choice of dealing with it or not, it's an absolute fundamental imperative for development," said Dr. Douglas Bettcher, WHO's director for the Tobacco Free Initiative, told Xinhua in a recent telephone interview.With NCDs already claiming 36 million lives a year -- nearly 100,000 people a day -- the UN Geneva-based health agency, WHO warns that deaths from chronic diseases will continue to climb even faster, amounting to 52 million deaths by 2030.As world leaders on Monday kicked off a two-day high-level meeting to enact a roadmap to attack diseases like cancer, diabetes, heart and lung diseases, it is hoped that the summit on NCDs, which is being called a "once in a generation opportunity," moves to become a "worldwide priority," Bettcher said.Marking the second time in its history that the United Nations General Assembly has ever put a global disease on the table, health experts and world leaders from 193 nations met to avert what the UN has declared a "public health emergency in slow motion. ""It's a make it or break it time for moving forward this very important agenda at this time of global financial crisis," said Bettcher.Calling NCDs the top global killer "by a long shot," Bettcher attributed such rises in deaths partly to the aging of the world's population, rapid urbanization and increased exposure to risk factors, particularly in low-and middle-income countries."This is a landmark meeting," said UN Secretary-General Ban Ki- moon at the opening of the unprecedented meeting. "Three out of every five people on earth die from the diseases that we gather here to address."The last time the UN looked at a health issue under the global microscope on such a high-level was almost a decade ago.

SAN FRANCISCO, June 1 (Xinhua) -- Microsoft on Wednesday gave a preview of its next-generation operating system code-named "Windows 8."The software giant introduced the successor to Windows 7 at the ninth edition of The Wall Street Journal's Digital: All Things Digital in Rancho Palos Verdes, California, some 48 km south of Los Angeles.With an interface quite different from legacy Windows, Windows 8 looks more like Windows Phone 7 and features an app management from Windows mobile operating system. It is the first major attempt by Microsoft to expand a mobile operating system to desktop status, and is expected to be touch-friendly and work seamlessly on desktops, laptops and tablet computers.For legacy Windows users, they need to swipe up from the bottom of the screen to get to the Windows 7-based view. Microsoft said the new system will be compatible with all Windows 7 logo PCs, software and peripherals.During the demonstration, Steven Sinofsky, Microsoft's head of Windows, also said the importance of not abandoning the established technologies from the traditional PC. "The mouse and the keyboard aren't evil. They're just tools. There are a number of applications that require the greater precision offered by the mouse." said Sinofsky.Sinofsky did not say when Windows 8 would be available.Although there are some tablets running Microsoft's current Windows 7 operating system, the software giant has been criticized for failing to adequately respond to the fast growth of tablet computers, like Apple's iPad.