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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.

BEIJING, Feb. 14 (Xinhuanet) -- The exchange rate against the US dollar is currently at an appropriate level but could fluctuate in the future, Yi Gang, vice-governor of the central bank and head of the State Administration of Foreign Exchange, said on Sunday."In the future, as markets fluctuate and labor productivity changes, the rate will certainly show some fluctuation," he said at a seminar. Last Thursday, the yuan's central parity rate rose to a record high of 6.5849 against the US dollar, after rising for three consecutive trading days, before declining to 6.5952 on Friday.The yuan has appreciated about 3.6 percent against the dollar since mid-June. A report from the US Treasury said earlier that on an inflation-adjusted basis, the appreciation was even higher, at an annual rate of more than 10 percent.US Federal Reserve Chairman Ben Bernanke said last Wednesday that China's recent measures to control inflation by raising interest rates is "surprising" and urged Beijing to let its currency rise in value.Currently the exchange rate is still underestimated by no more than 10 percent, said Lu Mai, secretary-general of the China Development Research Foundation (CDRF).The resilience of exporters to the rising yuan is stronger than previously estimated, which helps to pave the way for more currency reform to liberalize the yuan, he said.In 2007 and 2008, the Chinese currency rose by 7 percent annually against the US dollar, but China's GDP only declined by 0.28 percentage points, with inflation down by 0.42 points and workers' wages up by 0.07 points, according to CDRF research."The figures showed that progressive currency reform since July 2005 was successful, and the government should accelerate the reform and further free the yuan in the next five years to promote healthy, long-term economic development," Lu said.China should keep the proportion of its trade surplus to GDP within 5 percent, and avoid further increasing its huge foreign exchange reserves to allow the currency to settle at a balanced level, he said.China's foreign reserves rose to a record .85 trillion at the end of last year, an 18.7 percent increase year-on-year, according to statistics from the People's Bank of China, the central bank.Yi said he took note of the CDRF findings, but emphasized that further moves depended on both the domestic and international economic situation and appropriate timing.Lu Feng, an economist at Peking University, said now is the right time to deepen currency reform and let the yuan trade at a higher price as inflation is rising.Analysts have predicted that the yuan will appreciate this year as inflation may see the government opt for a rising yuan to lower the cost of purchasing international commodities.Lian Ping, chief economist at the Bank of Communications, predicted the yuan would rise by 5 to 7 percent in 2011.

HAIKOU, Jan. 28 (Xinhua) -- China's aviation authorities on Friday started to allow helicopters to fly in low-altitude airspace over the tourist island of Hainan on a trial basis for the first time. The aim is to eventually open a part of the country's tightly-controlled airspace to private aircraft.Four helicopters were manned by eight pilots from Shanghai-based Zhengyang Investment Group, a leading domestic firm in the general aviation industry. They are expected to conduct test flights in the sky, 1,000 meters above the ground in Hainan in the next two months.The flight test will collect data for low-altitude flying and test the ground control system's response to emergencies, said Zou Jianming, chairman of Zhengyang Investment Group.Hainan is the first place in China to conduct test flights of private aircraft in low-altitude airspace, said Jiang Sixian, deputy governor of the province. Domestic and foreign firms are both welcome to invest in Hainan's general aviation sector to develop world-class tourism here.China's low-altitude airspace is controlled by the Air Force and the Civil Aviation Administration of China (CAAC). Every private aircraft flight needs approval, and the procedure can take from one day up to a week.But last November, the State Council and the Central Military Commission said that part of the low-altitude airspace would be opened to promote the country's general aviation sector, including the purchase and use of private planes.General aviation refers to the part of the aviation industry that excludes flights for military, law enforcement and public transport. China has only 900 aircraft, 80 airports and fewer than 10,000 pilots in the general aviation segment.The market for general aviation in China is valued at only 13 billion yuan (1.98 billion U.S. dollars) but is expected to grow by 15 percent annually until 2020, Hainan aviation officials said.

CHENGDU, May 8 (Xinhua) -- As a brand-name herbal capsule for cardiovascular disease in China, Di'ao Xinxuekang only needs to wait for another 15 years before reaching the EU market."The Dutch medical supervisors have recognized it as a qualified drug, but we still lack the evidence of 15-year presence in the EU market," said Ji Jianxin, a research manager with the drug's developer Di'ao Group based in southwest China's Sichuan Province.Di'ao, one of the largest Traditional Chinese Medicine (TCM) manufacturers, has been quite depressed, as many other TCM enterprises in China, by a European Union directive on traditional herbal medicinal products fully implemented from the beginning of this month.The directive requires that all herbal medicinal products, must obtain a medical license from any EU member state before it can be allowed in the EU market.It introduced a so-called simplified registration procedure with a seven-year transition period for traditional herbal medicinal products to be licensed, including Chinese and Indian ones.However, not a single Chinese herbal medicinal product has been granted the license so far, mainly due to the prohibitive registration cost and lack of required evidence to prove the product had a 30-year history of safe use, including 15 years in the EU.With a history of more than 2,000 years, TCM did not enter into the EU market until mid-1990s, and it has been imported into the EU and sold to European customers as food supplements instead of drugs.Most Chinese producers and importers did not reserve the customs papers a decade ago, thus unable to prove the 15-year use of their products in European markets.While TCM's globalization won't be doomed by one single EU directive as TCM export value to EU only takes up 14 percent of the total in 2010, experts and industry insiders still have had serious concerns about its future."Most TCM even don't have standardized labels that can help consumers to find out its origin," said Xian Sheng, from the China Association of TCM Export Companies.

WASHINGTON, May 25 (Xinhua) -- Two U.S. astronauts conducted the third of four scheduled spacewalks for space shuttle Endeavour 's STS-134 mission on Wednesday morning, the U.S. National Aeronautics and Space Administration (NASA) announced.Endeavour's mission specialists Drew Feustel and Mike Fincke completed a six-hour-54-minute spacewalk at 8:37 a.m. EDT (1437 GMT). They completed all planned tasks, installing cables to increase redundancy for the power system on the Russian segment of the station, completing the external wireless antenna system work Feustel and Greg Chamitoff began during the first spacewalk, and installing a power and data grapple fixture to Zarya. The fixture will allow the station's robotic arm to "walk" to the Russian segment, extending its reach by using that grapple fixture as a base.It was the 247th spacewalk conducted by U.S. astronauts, and the 158th in support of space station assembly and maintenance, totaling 995 hours and 13 minutes. If everything goes as planned, the 1,000th hour of space station assembly and maintenance will be logged on Friday.Endeavour lifted off on May 16 from the Kennedy Space Center in Florida, to deliver to the International Space Station a 2-billion- dollar, multinational particle detector known as the Alpha Magnetic Spectrometer (AMS).AMS, a particle physics detector, is designed to search for various types of unusual matter by measuring cosmic rays. Its experiments are designed to help researchers study the formation of the universe and search for evidence of dark matter, strange matter and antimatter.NASA's 30-year-old shuttle program is ending due to high operating costs. The Obama administration wants to spur private companies to get into the space taxi business, freeing NASA to focus on deep space exploration and new technology development.There were initially five space shuttles in the fleet -- Challenger exploded shortly after liftoff in 1986 and Columbia disintegrated on its way back to Earth in 2003. Discovery retired earlier this year, while Endeavour is currently on its final mission. A last mission for Atlantis is scheduled for July, though funding for Atlantis remains in question.The sixth shuttle, Enterprise, did test flights in the atmosphere but was never flown into space. It is already on display at a museum outside Washington.When the U.S. space shuttle program officially ends later this year, the Russian space program's Soyuz capsule will be the only method for transporting astronauts to and from the station.