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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

The Education Department failed to include funding for the Special Olympics in its budget proposal this year after it was rebuffed by the White House's budget office, a department official familiar with the process tells CNN.Department officials tried repeatedly to include the nearly million in funding while still coming in under the White House's budget cap, but officials at the Office of Management and Budget rejected each proposal, according to the official.Education Department staff were forced this week to watch Secretary of Education Betsy DeVos defend before Congress the unpopular proposed cuts that officials there had largely opposed, only to have the President roll back the cuts two days later. One staffer described the experience to others as the "week from hell."DeVos faced intense scrutiny on Capitol Hill Tuesday over her proposed budget to the Special Olympics, which provides sports programs for children and adults with intellectual disabilities. 990

TAYLORTOWN, N.C. — A 12-year-old boy in North Carolina is recovering from injuries after being dragged and run over by the school bus he was riding Wednesday afternoon, according to the North Carolina State Highway Patrol.The boy, identified as Zion Baker, was getting off the school bus when the doors closed on his backpack and the bus began to move, dragging him about 10 feet, authorities said. He was able to break free from his backpack but the rear tire of the bus ran over his arm.The mother of the boy, Serena Thomas, 539

The American Red Cross said on Tuesday that it is in need of blood donations from healthy people amid the spread of COVID-19. The Red Cross said that the cold and flu season has already impacted the nation's ability to maintain its blood supply. The organization is concerned that a widespread outbreak of the coronavirus would cause fewer otherwise healthy individuals to give blood. The Red Cross said that its process is safe, and that it will take precautions to avoid spreading germs. Red Cross staff will be wearing gloves, routinely wiping down donor-touched areas, using sterile collection sets for every donation, and preparing the arm for donation with an aseptic scrub."We're asking the American people to help keep the blood supply stable during this challenging time. As communities across the country prepare for this public health emergency, it's critical that plans include a readily available blood supply for hospital patients," said Chris Hrouda, president, Red Cross Blood Services. "As fears of the coronavirus rise, low donor participation could harm blood availability at hospitals, and the last thing a patient should worry about is whether lifesaving blood will be on the shelf when they need it most."Please make an appointment to donate blood now by using the Red Cross Blood Donor App, visiting 1336

The Los Angeles sheriff says gun shops are not essential businesses and he ordered them to stop selling to the public. The move by Sheriff Alex Villanueva on Tuesday enraged Second Amendment advocates, who said they planned to challenge it in court. Los Angeles County, the nation’s largest county with 10 million residents, enacted a stay-at-home order last week requiring all nonessential businesses to close. The sheriff says what he described as a “loophole” allowed gun shops to stay open and many attracted long lines of customers. Villanueva said the order was only meant to keep open businesses that support police departments and other security organizations.California is under a "stay-at-home" order amid the spread of coronavirus. The order requires non-essential businesses to effectively close in order to slow the spread of the virus. 862

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