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SAN DIEGO (CNS) - Authorities reached out to the public Wednesday for help in tracking down a motorist involved in a fatal hit-and-run on a Clairemont- area street last month.The unidentified driver's black four-door sedan struck and killed 44- year-old Shane Moore as he was crossing the street in the 5500 block of Clairemont Mesa Boulevard shortly before 7:30 p.m. Jan. 22, according to San Diego police and the county Medical Examiner's Office.The motorist continued driving and fled the area to the east. An SUV then ran over the mortally injured pedestrian.Moore, who apparently was homeless, died at the scene, despite efforts by witnesses to render first-aid.Based on broken-off car parts found at the site of the traffic fatality, investigators believe the vehicle that struck Moore was a 2016 or 2017 Honda Accord, police said.Anyone who might be able to help identify the hit-and-run driver is asked to call San Diego County Crime Stoppers at 888-580-8477 or contact the agency online at sdcrimestoppers.org. Tipsters may remain anonymous and could be eligible for a reward of up to ,000. 1109

SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A pedestrian was struck and killed by a BNSF freight train at the Old Town Transit Station in San Diego, authorities said this morning.Officers responded to the station, in the 4000 block of Taylor Street near Congress Street, at 9:25 p.m. Friday and found the victim dead at the scene, according to Deputy Brian Abraham of the San Diego County Sheriff's Department.The age, gender and name of the victim were not disclosed.Anyone with information about this incident was asked to call the sheriff's department at 858-565-5200. 553

SAN DIEGO (CNS) -- Homicide detectives Friday were investigating the death of a man who was found unconscious in a Midway District parking lot.Dispatchers received a call around 10 p.m. Thursday from a person who reported finding the man in a parking lot in the 3700 block of Rosecrans Street, San Diego police Lt. Andra Brown said.Officers and paramedics responded to the scene and were directed to the 31-year-old victim, who had suffered trauma to his upper body, Brown said.The man was taken to a hospital, where he was pronounced dead at 10:38 p.m., the lieutenant said. His name was withheld pending family notification.Police announced Monday that Zarchari Mock, 29, was arrested in connection with the homicide. Anyone with information about the death is asked to call SDPD's homicide unit at 619-531-2293 or Crime Stoppers at 888-580-8477. 856

SAN DIEGO (CNS) - California Attorney General Xavier Becerra filed a lawsuit today against the Trump administration over its plan to begin construction on a border wall in San Diego and Imperial counties.Speaking to reporters at Border Field State Park, Becerra said he filed a complaint in federal court in San Diego that alleges legal and constitutional violations. He said the lawsuit was filed on behalf of the state and California Coastal Commission."The border between the U.S. and Mexico spans some 2,000 miles -- the list of laws violated by the president's administration in order to build this campaign wall is almost as long," Becerra said. "The Department of Homeland Security would waive 37 federal statutes, as well as regulations that 757

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