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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — Mission Valley's Gordon Biersch restaurant may be closing, but the brewery location will live on under a new local eatery.Puesto will take over the location of the well-known restaurant after it closes in July, according to the company. The Mission Center Road spot will be the Mexican restaurant's third location.Gordon Biersch is set to leave Mission Valley on July 16, though no reason was immediately given for the closure, according to paperwork filed by the company. RELATED: Uber Eats to test drone delivery service in San DiegoPuesto will reopen the on-site brewery and try to retain as many of Gordon Biersch's staff as possible. The new restaurant plans to open in Fall 2019.The on-site brewery will give Puesto the opportunity to develop their own beer program, after collaborations with San Diego and Mexico breweries for years, in addition to its signature margaritas and cocktails.“The Puesto team has been doing cervecería collaborations for years now, working primarily with cervecerías in Mexico to create our own San Diego meets Mexico cervezas," Puesto co-owner Eric Adler said. "We’ve been looking for a space in San Diego for some time where we could develop our own cerveza program. This new space gives us the opportunity not only to brew, but continue bringing our innovative approach to authentic Mexican flavors to more of our hometown.”Puesto currently operates six restaurants around California, offering a variety of handmade tacos, bowls, and street food-style plates. 1525

SAN DIEGO (KGTV) -- If you have ever visited Lake Miramar, you know it is home to Chinese geese. But one goose, in particular, is healing both man and fellow beast. Louie is hard to miss He's the only white Chinese goose left at the lake and he's a bit of a celebrity.Dave Brandenburgh works at the concession and bait store at the lake and feeds the geese every day."Best part of my day is feeding the kids ... they always want food, but Louie is the one you have to watch out for, one minute he will be eating out of your hand and the next minute he will take my leg off!" Brandenburgh says.Nearly 100 visitors a day want to know where the cranky, white goose named Louie is located. But he has a soft spot for a little abandoned duck, named Alphie."This new little person thinks he's a goose, his bottom feathers haven't developed yet. Louie has taken him under his wing and adopted him," said Brandenburgh.But Louie's true love is a woman named "Mother Goose.""He just loves her and she's the goose whisperer," said Brandenburgh.Louie is known to attack but when he sees Mindy Dreiserd he turns to mush. She has visited him every day for 4 years. He's never tried to bite her. She can hug and even pick him up. When he had a respiratory infection, she nursed him back to health. And when she struggled with alcoholism and depression he was there for her."He's been the reason I've been sober ... that connection and desire ... he makes me happy when I question why sober anyway," Dreiserd said.With Lake Miramar garnering increased attention, the City of San Diego is reminding visitors to not feed the animals.In a statement, the city said: "For the safety of the public, it is against the rules for anyone to feed ducks, geese or any other wild animals at City of San Diego reservoirs." 1800

SAN DIEGO (KGTV) - Kelvin Barrios, a candidate for the San Diego City Council's 9th District, has announced he has contracted coronavirus."After being hospitalized two days ago, I have tested positive for COVID-19," Barrios said in a Facebook post. "While I have been following all social distancing and self-isolation recommendations, I had what I thought was a normal flu for about a week," he said.Barrios described feeling "bad body aches, sweating, headaches, labored breathing, high blood pressure, and an elevated heart rate.""I strongly urge everyone to practice social distancing and stay safe and healthy during these times," he said. 652

SAN DIEGO (KGTV) - IKEA is recalling a type of candy sold at certain stores in California, including the San Diego location in Mission Valley.The Godis P?skkyckling marshmallow candy may be contaminated. The chain did not immediately release the source of the possible contamination but said the health risk is low.IKEA said the candy is a seasonal product and only 400 bags have been sold since it became available in February.If you bought the candy, you may return it to the nearest IKEA store for a full refund. 523

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