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Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730
A lot of unloading, probably 100 cases of wine being unboxed and stored nearby. Owner says there’s a lot more inside, the floor fell on top of it. @WCPO pic.twitter.com/mClL4tUPVs— Ally Kraemer (@AllyKraemer) June 13, 2019 234

A lawyer for an indicted associate of Rudy Giuliani tells CNN that his client is willing to tell Congress about meetings the top Republican on the House Intelligence Committee had in Vienna last year with a former Ukrainian prosecutor to discuss digging up dirt on Joe Biden.The attorney, Joseph A. Bondy, represents Lev Parnas, the recently indicted Soviet-born American who worked with Giuliani to push claims of Democratic corruption in Ukraine. Bondy said that Parnas was told directly by the former Ukrainian official that he met last year in Vienna with Rep. Devin Nunes."Mr. Parnas learned from former Ukrainian Prosecutor General Victor Shokin that Nunes had met with Shokin in Vienna last December," said Bondy.Shokin was ousted from his position in 2016 after 782
A “credible” threat over the new psychological thriller “Joker" forced a California movie theater to close down temporarily, police said.Authorities were called to the Century Huntington Beach and XD theater on Thursday about a possible threat in response to the opening of the film, which has been cause for concern over the 338
The Trump administration is officially banning bump-fire stocks, senior Justice Department officials told CNN Tuesday.Under a new federal rule, those who possess the devices, commonly known as bump stocks, will get 90 days to turn them in from the date that the final rule is published in the federal register, which is likely Friday, the officials said.Bump stocks gained national attention last year after a gunman in Las Vegas rigged his weapons with the devices to fire on concertgoers, killing 58 people. President Donald Trump vowed to outlaw the devices soon after the tragedy, and some lawmakers on Capitol Hill urged him to back a permanent legislative fix.But opposition from lawmakers and the National Rifle Association ultimately made a regulatory change the only realistic path forward to accomplishing the President's goal. 855
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