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The crisis has created a diplomatic rift between Saudi Arabia and the West and led to international firms pulling out of a high-profile summit in Riyadh. The CEOs of three top banks -- Standard Chartered, HSBC and Credit Suisse -- announced their withdrawal from the conference Tuesday.International Monetary Fund Managing Director Christine Lagarde was the latest senior invitee to pull out, according to a Tuesday statement.Prominent Republican lawmakers on Tuesday forcefully demanded answers and retaliatory action over the disappearance, with Senator Lindsey Graham threatening to "sanction the hell" out of Saudi Arabia.President Trump has been reluctant to castigate the kingdom, a key US ally that plays a central role in his administration's Middle East policy, despite growing pressure at home and internationally.Trump and his son-in-law, Jared Kushner, have also developed personal and business relationships with the Saudis.Kushner has developed close links with the crown prince, whose attempts to foster an image as a reformer may be fatally damaged by the crisis.The prince's reputation has already been tarnished by the detention of Lebanon's prime minister, the war in Yemen, his arrest of large numbers of Saudi's elite, and the campaign against Qatar, as well as the imprisonment of activists.In an interview with CBS' "60 Minutes," Trump bristled at the idea of cutting weapons sales to Saudi Arabia, and in comments on Monday, he touted a denial from the Saudi King and offered up the idea that "rogue killers" may have been involved.Trump's comments may be a sign that Washington is preparing to accept Saudi Arabia's efforts to distance its leaders from whatever fate befell Khashoggi.Sources have told CNN that the kingdom was preparing a report to acknowledge that Khashoggi died at the consulate in Istanbul in an interrogation that went awry. The sources said the interrogation was intended to lead to his enforced return to Saudi Arabia.One source said the report will likely conclude that the operation was carried out without clearance and transparency and that those involved will be held responsible. 2133

The Cuyahoga County Board of Health and Summit County Public Health are both applying for state funding, as is the Cleveland Department of Public Health."I think that the funds show a commitment by the state level health department to aggressively address this outbreak," said Andrew Heffron, clinic supervisor at the Cuyahoga County Board of Health.Heffron said the number of hepatitis A cases statewide has been steadily increasing since the outbreak began more than a year ago.Hepatitis A is a virus that affects the liver, according to Heffron, who described some of the common symptoms as "abdominal pain, very dark yellow urine, nausea and the most common symptom that people think about is jaundice, which is yellowing of the skin."The virus is commonly foodborne, but according to Persis Sosiak, commissioner of health at the Cleveland Department of Public Health, that's not the case in this outbreak."In this particular outbreak, it is much more associated with intimate contact and risky behaviors," Sosiak said.County and local health departments are trying to reach at-risk populations through vaccination and education."That includes individuals incarcerated, the homeless population, men who have sex with men," Heffron said.It also includes people traveling to developing countries and people who use illicit drugs, whether the drugs are injected or not.The number of cases in this outbreak is much higher than in a typical year, Heffron said, and those who are most in need of vaccination are very young children and people with liver diseases such as hepatitis B or hepatitis C."Historically, Ohio has about 40-some cases a year, so it’s a little concerning that we’re at the numbers we’re at," Heffron said."The hepatitis A vaccine consists of two doses, one of which is 94 to 95% effective on its own," Sosiak said."We would always recommend two doses, but if even getting one, you are giving yourself or your family a high degree of protection against the infection," Sosiak said.While medication can be given to help with hepatitis A symptoms, Heffron said the virus usually clears itself from someone's system with rest and fluids. 2154

The costs of climate change could reach hundreds of billions of dollars annually, according to the report. The Southeast alone will probably lose over a half a billion labor hours by 2100 due to extreme heat.Farmers will face extremely tough times. The quality and quantity of their crops will decline across the country due to higher temperatures, drought and flooding. In parts of the Midwest, farms will be able to produce less than 75% of the corn they produce today, and the southern part of the region could lose more than 25% of its soybean yield.Heat stress could cause average dairy production to fall between 0.60% and 1.35% over the next 12 years -- having already cost the industry .2 billion from heat stress in 2010.When it comes to shellfish there will be a 0 million loss by the end of the century due to ocean acidification, which is already killing off shellfish and corals. Red tides, or algae bloom that deplete oxygen in the water and can kill sea life -- like those that triggered a state of emergency in Florida in August -- will become more frequent. 1079

The co-hosts for the 51st Annual CMA Awards, Brad Paisley and Carrie Underwood, had already previously confirmed that Wednesday night's broadcast will include a mention of the individuals that lost their lives in the Las Vegas shooting. 236

The crash involving a Dodge Ram truck and Toyota Camry was reported shortly after 11 a.m. on SR-78 near W. Haverford Road, according to the California Highway Patrol. 166