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New research suggests that antibodies the immune system makes to fight the new coronavirus may only last a few months in people with mild illness, but that doesn’t mean protection also is gone or that it won’t be possible to develop an effective vaccine.“Infection with this coronavirus does not necessarily generate lifetime immunity,” but antibodies are only part of the story, said Dr. Buddy Creech, an infectious disease specialist at Vanderbilt University. He had no role in the work, published Tuesday in the New England Journal of Medicine.The immune system remembers how to make fresh antibodies if needed and other parts of it also can mount an attack, he said.Antibodies are proteins that white blood cells called B cells make to bind to the virus and help eliminate it. The earliest ones are fairly crude but as infection goes on, the immune system becomes trained to focus its attack and to make more precise antibodies.Dr. Otto Yang and others at the University of California, Los Angeles, measured these more precise antibodies in 30 patients diagnosed with COVID-19 and four housemates presumed to have the disease. Their average age was 43 and most had mild symptoms.Researchers found that the antibodies had a half-life of 73 days, which means that half of them would be gone after that much time. It dovetails with a previous report from China also suggesting antibodies quickly fade.The results “call for caution regarding antibody-based ‘immunity passports,’ herd immunity, and perhaps vaccine durability,” the California authors write.That’s true, Creech said, but other parts of the immune system also help confer protection. Besides churning out antibodies, B cells develop a memory so they know how to do that again if needed.“They would get called into action very quickly when there’s a new exposure to the virus. It’s as if they lie dormant, just waiting,” he said.Other white blood cells called T cells also are better able to attack the virus the next time they see it, Creech said.Although circulating antibodies may not last long, what we need to know is if and how people remake antibodies if exposed to the coronavirus again and if they protect against another infection, Alison Criss, an immunologist at the University of Virginia, wrote in an email. “We also need to know if there is a protective T cell response” that reappears.Vaccines, which provoke the immune system to make antibodies, might give longer-lasting protection than natural infection because they use purified versions of what stimulates that response, she noted.Creech agreed.“This shouldn’t dissuade us from pursuing a vaccine,” he said. “Antibodies are only a part of the story.”___Marilynn Marchione can be followed on Twitter at http://twitter.com/MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2967

NEW YORK — A federal appeals court ruled Wednesday morning that New York District Attorney Cyrus R. Vance Jr. can get access to President Donald Trump's personal and corporate tax returns.The ruling by a three-judge panel in New York rejected the president’s argument that the subpoena for his taxes should be blocked because it was too broad, and could be seen as political harassment from the DA.Vance says his office will not enforce the subpoena for 12 days in exchange for the president’s lawyers agreeing to move quickly, according to the New York Times.It has been over a year since the district attorney first subpoenaed eight years of Trump’s tax returns and other financial records as part of an investigation into the president’s business practices.Wednesday’s decision is the fifth time courts have rejected Trump’s attempts to block the subpoena. His lawyers are expected to appeal the ruling to the United States Supreme Court.Vance has not revealed the details of his office’s investigation, however court papers suggest they are looking at a range of potential crimes including tax and insurance fraud and falsification of business records, according to the New York Times. 1197

NESTOR, Calif. (KGTV) -- Some South Bay neighbors oppose the city of San Diego’s plans to build a sober-living drug treatment facility at the site of a Super 8 Motel in Nestor on Palm Avenue just west of the I-5.The Otay Mesa-Nestor Community Planning Group voted 9-2 Wednesday evening to not recommend the San Diego City Council approve the San Diego Misdemeanants At-Risk Track (SMART) program treatment center at the Super 8 Motel site.  RELATED: City plans to house criminals in South Bay HotelResidents at the meeting said they oppose the facility, mostly because it may interfere with plans to revitalize the area in the future.They believe a drug treatment facility will turn investors away.According to the city, there will be counselors on-site, 24-hour security, and strict rules.According to the City Attorney’s website, “SMART prioritizes chronic misdemeanor offenders with acute drug addictions and complex social service needs. These offenders have one or more drug offenses since Proposition 47 took effect in 2014, and have been arrested at least twice in the past six months for a quality-of-life offense.” 1141

NEW YORK (AP) — The operator of Ann Taylor and Lane Bryant filed for Chapter 11 bankruptcy on Thursday, the latest retailer to do so during the pandemic. Ascena Retail Group, which operates nearly 3,000 stores mostly at malls, has been dragged down by debt and weak sales for years. In a press release, the company said they were closing all of their plus-size stores Catherines.The company also said in the release that they plan to "strategically reduce its footprint with the closing of a significant number of Justice stores and a select number of Ann Taylor, LOFT, Lane Bryant, and Lou & Grey stores."It joins other retailers that have filed for bankruptcy in recent weeks, including Brooks Brothers, Neiman Marcus, J.C. Penney, and J. Crew. These retailers were already struggling with poor sales, but the forced closure of stores in March to reduce the spread of the coronavirus put them further in peril. Experts believe that there will be another wave of bankruptcies this fall that will include companies that had been healthy before the pandemic struck. 1076

New developments have surfaced in the search for a missing 3-year-old Georgia boy.Last week, police in New Mexico rescued 11 starving children, ages one to 15, who were living in squalor at a filthy compound. Among the trash and piles of junk that litters the compound in Amalia, New Mexico, authorities say they’ve found the remains of a young boy.The remains could be those of Abdul-Ghanni Wahhaj, who went missing in Georgia late last year. His fourth birthday was on Monday.Five adults were taken into custody after authorities raided the compound, where they found children living with no plumbing and rags for clothes. 632

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