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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438
SAN DIEGO (KGTV) – Authorities are asking for the public’s help in identifying and finding a man suspected of intentionally setting a fire in San Diego’s Little Italy area.On July 18, at around 3:45 a.m., a man allegedly lit a recycling dumpster on fire that was against a wall of the Mona Lisa Italian Foods on 2061 India Street.Authorities said the fire spread to the building and a delivery van parked near the dumpster.The blaze caused ,000 in damage.The man suspected in the arson case is white or Hispanic in his mid 20s to early 30s. He appears to be balding, unshaven and has a stocky build.Authorities said the man was shirtless at the time of the incident, but he was wearing skinny jeans and dark-colored loafer-style shoes.The man also has a large vertical tattoo along the right side of his rib cage.Anyone with information on the suspected arsonist or the incident is asked to contact the Metro Arson Strike Team (MAST) at 619-236-6815 or Crime Stoppers at 888-580-8477.Crime Stoppers is offering a reward of up to ,000 to anyone with information that leads to an arrest in the case. 1110

SAN DIEGO (KGTV) -- County Supervisor Jim Desmond said Friday that more businesses throughout San Diego County can reopen pending approval from health officials.Those businesses include nail salons, massages, and tattoo parlors.Supervisor tweeted out the statement Friday, saying: "Pending County Health Official's approval, next Friday personal services (nail salons, massages, tattoo parlors, etc.) will be able to open in San Diego County!"The news comes after county health officials allowed gyms, hotels, and bars, among other businesses to reopen beginning June 12.RELATED: San Diego County gyms, bars, movie theaters reopening June 12Those businesses, according to the county, were required to complete a "Safe Reopening Plan" and share it with their employees and display it where customers and patrons can see it.Businesses are also required to follow public health guidelines, including the use of face coverings, increased sanitation, and rotocals for social distancing. 989
SAN DIEGO (KGTV) -- As the nation continues to process what happened during the first presidential debate, many are expressing frustration about what didn’t happen.Local and national Latino American leaders are calling out the moderator and the candidates for making no mention of the millions of Latinos in the country.Just moments after the debate ended Tuesday night, organizations like the National Association of Hispanic Journalists shared a series of tweets highlighting that Latinos were not mentioned during the debate.According to the Pew Research Center, more than 32 million Latino voters are eligible to vote in November.Voters like Denisse Roldan Newell wanted to hear more from both candidates about their policies on a range of issues.“It's not just immigration, it's not just the border wall, it's having to do with economics, with smalls business development, with affordable health care, with education,” said Roldan Newell.Roberto Alcantar with the Chicano Federation told ABC 10News it was concerning that the candidates made no mention about COVID-19 and it’s disproportionate affect on the Latino community.In San Diego, Latinos make up 34% of the population but 65% of COVID-19 cases."These are not just Latino issues, these are issues for all of us as American. While, yes, we are Latinos, we are American and our issues are America’s issues," said Alcantar. Locally, Latino leaders like Roldan Newell and Alcantar hope the debate organizers and moderators to make a change before the next debate.The next debate is between the vice presidential candidates on Wednesday, October 7th. 1616
SAN DIEGO (KGTV) -- Attorney General Jeff Sessions visited the U.S.-Mexico border Monday for a news conference. During the conference, Sessions announced that he would be referring all illegal border crossings to the Department of Justice. Sessions said he will be implementing a "zero tolerance" policy and that any people crossing the border illegally will be prosecuted. RELATED: President Trump visits border wall prototypes?"The American people are right and just and decent to ask for this. They are right to want a safe and secure border and a government that knows who is here and who isn't," Sessions said. During the news conference, a protestor interrupting Sessions shouting, "Do you have a heart? Do you have a soul? Why?"Immigration and Customs Enforcement Deputy Director Thomas D. Homan also spoke at the news conference. RELATED: Vice President Mike Pence visits US-Mexico border in Calexico The visit comes a week after a caravan of migrants from Central America arrived at the U.S.-Mexico border.Sessions’ visit marks the third high-profile visit from the Trump administration in the last two months.President Trump visited the border wall prototypes in March followed by a visit by Vice President Mike Pence in April.The Democratic National Committee released the following statement before Sessions' visit: 1386
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