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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.
MADRID, Jan. 24 (Xinhua) -- The Spanish branch of Industrial and Commerce Bank of China (ICBC) was officially inaugurated in Madrid Monday.ICBC President Jiang Jianqing, Spanish Minister of Industry, Tourism and Commerce Miguel Sebastian and Chinese Ambassador to Spain Zhu Bangzao attended an inaugural gala dinner here.In a speech, Jiang thanked the Spanish government and authorities for allowing the ICBC to open in Spain and highlighted the importance of the Spanish economy and the close relations between the two countries.Sebastian said Spain welcomes the arrival of the biggest Chinese bank, which would further improve the already good relationship between the two counties.The Madrid branch is to provide a wide range of financial services to 166,000 Chinese nationals living in Spain.ICBC has a total of 386,723 employees and 162 foreign branches throughout the World.

CANBERRA, April 14 (Xinhua) -- Scientists on Thursday expressed disappointment to the decision to cancel the long-running Australian Science Festival in Canberra.The festival has been operating during August for the past 19 years with free and ticketed science education activities.However, the festival organizers on Wednesday announced to halt this year's program after failing to secure support from the Australian Capital Territory state government in time to arrange events.According to Australian Science Communicators president, Jesse Shore, thousands of school children have attended the festival over its history to learn more about science as a career."It's encouraged other activities to join it, it was very important in getting National Science Week started, and that's stimulated a lot of other science communication activities," he told ABC News on Thursday.Shore said the decision to close it down is unfortunate as the event has been very influential and instrumental promoting science communications activities.He said he hopes that a number of people would gather together in a new partnership, with new ideas and hopefully a new funding base.
BEIJING, Feb. 5 (Xinhua) -- China's meteorological authority said Saturday that a cold snap would sweep north China over the next few days, bringing down temperatures and carrying gusty winds.Temperatures in some parts of Xinjiang Uygur Autonomous Region, Inner Mongolia Autonomous Region and northeast China will drop 4 to 6 degrees Celsius over the weekend, the National Meteorological Center (NMC) said in a statement on its website.In most areas north to the Huaihe River, the temperatures will go down 4 to 6 degrees Celsius, or even 8 to 10 degrees Celsius in some parts of the areas between Monday and Tuesday.The cold front would then move southward to affect more areas in the eastern and southern parts of the country.The NMC said some areas in northern and western Xinjiang Uygur Autonomous Region, the eastern part of Inner Mongolia, Sichuan Basin and most of the northeast China, the western parts of the areas south to the Yangtze River will see light to moderate snow or sleet in the forthcoming three days.Fog continued to shroud south China Saturday, reducing visibility to less than 200 meters in parts of Hunan, Hubei, Jiangxi, Sichuan and Fujian provinces, as well as Chongqing City.
BEIJING, Jan. 30 (Xinhua) -- Chinese Vice Premier Li Keqiang Sunday urged scientists to learn from foreign experiences and increase their participation in international cooperation in polar and oceanic exploration.Li made the remarks after meeting with members of China's 27th Chinese Antarctic expedition team, the 22nd oceanic expedition, and scientists working in the country's Antarctic and Arctic stations via video and telephone.Li said many countries nowadays attached great importance to polar and oceanic exploration, and international competition had grown in promoting the peaceful utilization of these resources.Chinese Vice Premier Li Keqiang (R, front) shakes hands with a senior Chinese explorer in Beijing, capital of China, Jan. 30, 2011. Li conveyed Spring Festival greetings while meeting with members of China's 27th Chinese Antarctic expedition team, the 22nd oceanic expedition, and scientists working in the country's Antarctic and Arctic stations via video and telephone on Sunday."We are confident and capable of constantly improving our working conditions to conduct polar and oceanic exploration, and winning the initiative in this sector's future development," Li said.Li said the country would work to promote its marine economy and safeguard marine ecosystems, as well, and make full use of the achievements made in explorations to make reasonable development and utilization of ocean resources.China would also ensure the security of ocean passages, and safeguard its marine rights and interests, the vice premier said.Li also conveyed New Years greetings to the scientists for conducting research away from their homeland and families, and applauded their contribution to the country's progress in polar and oceanic research areas.
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