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Their youthful brains were developing normally, with no signs of developmental, psychological or neurological problems. None had ever had a concussion. But by the end of a single football season, 24 children between the ages of 9 and 18 who had more frequent impacts to the head showed signs of damage to brain development, new research says."Repetitive head impact exposure may have a cumulative effect in the rapidly developing brains of youth and high school football players," said study co-author Gowtham Krishnan Murugesan, a radiology research assistant at UT Southwestern Medical Center in Dallas, adding that the results mirror other recent findings.The study outfitted 60 youth and high school football players who had no history of head trauma or developmental issues with a head impact telemetry system that measures the magnitude, location and direction of impacts to the head. The researchers were not looking at whether the impact resulted in a concussion, only that impact occurred.The children were sorted into two categories: high cumulative head impact players (24) and low cumulative head impact players (36).Before beginning to play, each child had a resting state functional scan, known as an fMRI; the scans were repeated at the end of football season. The researchers were trying to see how exposure to repetitive hits affects the normal "pruning" process in the brain that occurs during adolescence."Pruning is an essential part of brain development," Murugesan said, comparing the process to how a tree needs to have dead or unneeded branches cut to keep it healthy and allow it to grow."Disruption in normal pruning has been shown to be related to weaker connections between different parts of the brain," he said.After comparing the functional MRI results to the player's level of impact, the researchers found that youth in the high-impact group had damage to their brains' pruning process after one season."Our study has found a significant decrease in gray matter pruning in the frontal default mode network, which is involved in higher cognitive functions, such as the planning and controlling of social behaviors, " Murugesan said.Although the "teenage years are a critical time for brain development, brain remodeling or synaptic pruning, this was a short-term study and did not follow the players longitudinally over several years. We don't really know the full application," said Dr. Julian Bailes, director of neurosurgery and co-director of the NorthShore University HealthSystem Neurological Institute, who was not involved in the research.Weill Cornell neurologist Dr. Richard Isaacson, who was also not involved in the study, called the research "early" and said the results don't necessarily "translate to a clinical or cognitive outcome." More research is needed to see whether the decline in brain pruning permanently affected the child's cognitive function or whether the brain's natural plasticity allowed it to repair itself."I would call this a pilot study," Isaacson said. "The call to action would be that we need more robust longitudinal studies with a pre- and a post-assessment of more than brain imaging. The study should also measure cognitive and neurological function and look for changes."As we learn more about the issue, Isaacson said, parents should do everything they can to limit contact in sports, "especially in practice before games, where studies show the majority of contact occurs." 3464

This week's mail bombs have spurred another reexamination of security practices at CNN and other major newsrooms.Even after Friday's arrest of a suspect in the bombing spree, journalists have been urged to stay vigilant and take threats seriously.Two of the packages found so far were sent to CNN's New York offices at Time Warner Center. Wednesday's package, addressed to former CIA director John Brennan, who actually works for NBC, arrived in the mailroom and forced an evacuation of the building.Friday's package, addressed to CNN contributor James Clapper, the former director of National Intelligence, was intercepted at a nearby post office.All mail destined for CNN's US offices is now being screened first at off-site facilities.This means the package to Clapper "would NOT have come directly to the TWC, even if it hadn't been intercepted first," CNN Worldwide president Jeff Zucker said in a Friday morning memo.Zucker held an informal town hall for New York employees on Thursday to share security updates and answer questions. When he thanked the company's security team, there was a long round of applause. "Thank you for an incredible job," Zucker said to the security personnel.Officials at other major media companies have been on a heightened state of alert.The security department at News Corp, which owns the Wall Street Journal and other newspapers, told staffers on Wednesday, "We are treating this situation with extra vigilance."There were scares at the Los Angeles Times and the San Diego Union-Tribune that day.But to date the only other media company that has received a mail bomb is Tribeca Enterprises, the home to Robert De Niro's production company in Lower Manhattan.Some of the security adjustments have been visible: Magnetometers have been installed at the entrances of the CNN Center in Atlanta, which is partially open to the public.But some of the efforts are purposefully hard to spot. And media companies generally try to say as little as possible about security."Ensuring the safety and security of our staff is of critical importance and we've taken steps to expand security measures given the current environment, but as a matter of policy, we won't discuss this in any more detail," The New York Times said in a statement.At the newspaper's headquarters, the NYPD recently installed concrete blocks along the sidewalk, a move that appears to be designed to protect the building from a vehicular attack.News executives and their security offices have decades of experience with belligerent customers, unstable viewers, and menacing readers who send threatening letters or show up at offices.Acts of violence are rare, though not unprecedented. Acts of harassment, stalking and violent threats are more common. Security staffs sometimes work with local and federal law enforcement on these cases.CNN on Friday publicly thanked the FBI, the Department of Justice, the NYPD, the Bureau of Alcohol, Tobacco, Firearms and Explosives and the United States Postal Service for their "incredible work" in a tweet, underscoring the coordination it takes to defuse these kinds of dangers.Journalism advocacy groups say that these problems are on the rise, partly due to a steady stream of anti-media attacks by political leaders.In August, for example, a California man was arrested for allegedly calling the Boston Globe and threatening to kill employees. The paper had recently led a nationwide editorial-writing effort decrying President Trump's "enemy of the people" rhetoric. The man, who has pleaded not guilty, allegedly used that term in his phone calls.In some cases, violence against newsrooms has nothing to do with politics. The shooting spree at the Capital Gazette newspaper in Annapolis, Maryland on in June, which left five employees dead, happened after the suspect had a long-running feud with the paper.On Monday, a man tried to break into the offices of WTTG, the Fox-owned local station in Washington.The intruder kicked down the glass doors in the lobby and tried to enter further into the building. He was shot once in the chest by a security guard.The man was later hospitalized, and no one at the station was injured.The suspect "was known to both Fox executives and police, according to sources, and had leveled threats against both previously," according to WTTG's own story about the incident. It said that the man "has previously sent emails to employees of FOX 5" and "is suspected to have mental health issues."Every time there's a newsroom evacuation or worse, journalists react the same way: by covering the story thoroughly.WTTG began live coverage of the break-in right away. CNN used the Skype app and cell phone connections to broadcast live during the evacuation. And the survivors of the The Capital Gazette set up a temporary newsroom after the attack there."This is a scary time," New York Times publisher A.G. Sulzberger said at a business journalism gala in New York on Thursday night.He was interviewed on stage by Kara Swisher, who asked him about his fears. Sulzberger responded by pointing out that reporters operate in war zones and other locales that are far more perilous than the streets of New York City."The New York Times tries never to operate from a place of fear," he said. "We've been operating around the world on the ground in dangerous environments for a long time. We know how to report when government minders are tracking us. We know how to report when our communications are being bugged. We know how to report when we're under threat." So, he said, he's "not particularly spooked" at this moment in time.CNN's Anderson Cooper made a similar point on Wednesday night, when he was broadcasting live from outside Time Warner Center."Terror only works when it produces fear. We are not afraid," he said. "We are here and we will be here tomorrow and we'll be here the day after and we'll be here the day after that. We have a job to do. [This] only makes our resolve that much stronger." 6044

TOWSON, Maryland — A Maryland pharmacist pleaded guilty to trading pain medication for sexual acts.Richard Daniel Hiller, of Owings Mills, Maryland appeared in court Friday when his plea was announced by United States Attorney for the District of Maryland Robert K. Hur; Chief Terrence B. Sheridan of the Baltimore County Police Department and other law enforcement officials. “Abuse of oxycodone and other pharmaceutical drugs is one of our most significant drug enforcement challenges," said U.S. Attorney Robert K. Hur. "Those who divert pharmaceutical drugs for illegal purposes further the tragic cycle of addiction and the epidemic of opioid overdose deaths.” According to Hiller's plea agreement, he worked as a licensed pharmacist in Towson, Maryland from 2014 to 2017.Hiller admitted to filling fake prescriptions for multiple women if given sexual favors. He would tell the women to come to the pharmacy before opening and have sex with the women before giving the painkillers.Officials say, when trying to cover the false prescriptions he would list fake names. The women were addicted to oxycodone and would resell many of the pills to maintain their addiction.  Over the years, Hiller distributed approximately 20,500 15 milligram oxycodone pills.He faces a maximum sentence of 20 years in prison for the conspiracy and distribution. His sentencing is scheduled for November 15, 2018, at 10 a.m.  1507

Top officials tapped with developing, approving and distributing COVID-19 vaccines say they're on track to begin distributing the first doses in the coming weeks and plan to vaccinate 100 million Americans by the end of February.In a press conference on Wednesday, Health and Human Services Director Alex Azar said the FDA would meet on Dec. 10 regarding Pfizer's vaccine candidate and on Dec. 17 regarding Moderna's vaccine candidate. The agency is currently reviewing both for Emergency Use Authorization.Both companies have been manufacturing doses of their candidate for several months in the hopes of ramping up supply in case of approval. Hundreds of thousands of doses of both doses will be ready for delivery as soon as approval is granted.Dr. Moncef Slaoui, Operation Warp Speed's chief advisor, stressed that the data from the vaccine trials are "clear" and shows both candidates to be safe and effective.According to Gen. Gus Perna, the operation's chief operating officer, the Department of Defense is prepared to deliver several million doses of both Pfizer and Moderna's vaccine upon approval. He said Wednesday that states are required to submit their "microplans" for Pfizer vaccine delivery to the Pentagon by the end of the week, and for the Moderna vaccine by the end of next week."The states know their populations the best," Perna said.Both Moderna's and Pfizer's vaccine candidates require two shots that need to be taken 28 days apart, and both vaccines need to be stored at ultra-cold temperatures before use.Slaoui said Wednesday that government officials expect 20 million Americans to be vaccinated by the end of December and that they project 100 million Americans will be vaccinated by the end of February.On Tuesday, an FDA panel recommended that health care workers and patients in long-term health facilities would be the first to receive the vaccine. Experts believe the vaccine will be available to everyone who wants it by spring 2021.Slaoui said Wednesday that government officials expect 20 million Americans to be vaccinated by the end of December and that they project 100 million Americans will be vaccinated by the end of February.Slaoui added that a one-shot vaccine candidate produced by Johnson & Johnson and a vaccine being developed by AstraZeneca could reach efficacy thresholds by the end of the month and that their approval would improve supply.Also on Wednesday, Azar stressed that new antibody treatments for COVID-19 are now available to any patients older than 65 who are not in the hospital. He also urged anyone who has recovered from COVID-19 in the last three months to donate their blood plasma to aid in those antibody treatments.The press conference was held the same day that officials in the United Kingdom granted emergency approval for the Pfizer vaccine. 2832

This morning, I tested positive for COVID-19. I am experiencing mild symptoms, and am following all appropriate protocols, including being in quarantine and conducting contact tracing.— Andrew H. Giuliani (@AndrewHGiuliani) November 20, 2020 249

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