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New studies confirm that multiple types of steroids improve survival for severely ill COVID-19 patients, cementing the cheap drugs as a standard of care.An analysis of pooled results from seven studies found that steroids reduced the risk of death in the first month by about one-third compared to placebo treatment or usual care alone in these seriously ill patients who needed extra oxygen.The work was led by the World Health Organization and published Wednesday by the Journal of the American Medical Association.Based on the results of the studies, the WHO has made two recommendations. The first, it says a strong corticosteroid therapy for 7 to 10 days should be used in patients with severe or critical COVID-19. The second, this therapy should not be used in patients with non-severe COVID-19, because it may increase the risk of death.“In contrast, in patients with non-severe COVID-19, based on data from 1,535 patients in one study, systemic corticosteroids may increase the risk of 28-day mortality,” researchers wrote.Compared to other treatments for COVID-19, these types of steroids are generally low cost, easy to administer and readily available across the globe.“Dexamethasone and prednisolone are among the most commonly listed medicines in national essential medicines lists; listed by 95% of countries. Dexamethasone was first listed by WHO as an essential medicine in 1977, while prednisolone was listed 2 years later,” the WHO wrote.The WHO added that clinicians should exercise caution in use of corticosteroids in patients with diabetes or those who are immunocompromised and could become severely ill do to COVID-19. 1651

New research may be hard for some dog owners to accept; the study found that dogs do not understand every word a human says to them.The researchers say dogs cannot hear subtle differences between words the way humans can. For example, the difference between “dog” and “dig” sounds different to human ears, but not so different to dog ears.The researchers came to their conclusion after measuring brain activity of family dogs by taping electrodes to the animals’ heads. They then played recordings of instruction words they knew, like “sit,” then similar-sounding nonsense words, like “sut,” and finally an unrelated nonsense word or sound, like “bep.”The dogs in the study, who were not trained ahead of the study, could quickly tell the difference between the instruction words and the unrelated nonsense words."The brain activity is different when they listen to the instructions, which they know, and to the very different nonsense words, which means that dogs recognize these words," lead study author and postdoctoral researcher at E?tv?s Loránd University in Budapest, Lilla Magyari told CNN.So, the good news is, yes, dogs are listening to human words and understanding some.However, brain activity showed a similar reaction in the dogs between the instruction word and the similar nonsense word.Dogs are renowned for their auditory capacity and ability to hear words and sounds, however the results show they may not be able to distinguish between subtle speech sound differences.Magyari says more research is needed to understand why this is."They may just not realize that all details, the speech sounds, are really important in human speech. If you think of a normal dog: That dog is able to learn only a few instructions in its life," she told CNN.The study was published this week in the Royal Society Open Science journal. 1845

North Dakota Senator Heidi Heitkamp is facing the very real possibility that she may have to say good bye to the seat she's held for the past six years.Heitkamp is a moderate Democrat, who touts her ability to make tough choices and not always voting based on politics. One of the hardest moments for her was voting "no" to Supreme Court nominee Brett Kavanaugh."I think that a lot of people wrote the political obituary after that vote, and it may in fact be that," says Heitkamp.Voting against Trump was also a risky move, in a state that voted for the president by a 36-point margin.When asked if that factored into her decision at all, Heitkamp replied, “No, because when you’re making this decision, especially on a Supreme Court justice, there’s no do-overs.”In recent polls, Heitkamp trailed her opponent, Congressman Kevin Cramer, by double digits.Having someone always stand with Trump seems to be what some voters in North Dakota are looking for.“She voted ‘no’ on Kavanaugh; that was a big deal to me,” says one voter.But there were plenty who would say the opposite.“I really admired her for doing what was right in her heart, rather than what she was pressured to do,” says another voter. “So, I admire her independence on that.”Heitkamp hopes that come Tuesday she'll beat the odds and be elected to serve another term. 1346

NEW YORK (AP) — Halloween is still weeks away, but retailers are hoping you'll start your holiday shopping now. The big push is coming from Amazon, which is holding its annual Prime Day sales event Tuesday and Wednesday. It's the first time Prime Day has been held in the fall after Amazon postponed it from July due to pandemic. Walmart, Best Buy, and Target are also offering online deals on TVs, toys, and other items over the same two days. There's a good reason for the early start. Retailers are worried that a rush of online orders could lead to shipping delays in November and December. And stores want to avoid big crowds inside their stores during the pandemic. 679

NEW YORK — The American Museum of Natural History is removing a statue of Theodore Roosevelt on horseback with a Native American man and an African man on his sides after objections that it symbolizes colonial expansion and racial discrimination. Mayor Bill de Blasio said Sunday the city supports removal of the statue because it depicts Black and Indigenous people as subjugated and racially inferior. The statue at the museum's Central Park West entrance depicts Roosevelt on the horse with the Native American man and the African man standing on either side. The museum’s president, Ellen Futter, tells the New York Times the decision to remove the bronze statue comes amid the movement for racial justice following the killing of George Floyd. 756